Protein Alignment Pgant8 and Galnt4

DIOPT Version :10

• Sequence 1: NP_648800.1
• Gene: Pgant8 / 39715
• FlyBaseID: FBgn0036529
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_056552.1
• Gene: Galnt4 / 14426
• MGIID: 894692
• Length: 578
• Species: Mus musculus
• Alignment Length: 637
• Identity: 193/637 - (30%)
• Similarity: 280/637 - (43%)
• Gaps: 137/637 - (21%)

  Fly     6 WRHKKKVLPLLLLMA---IGSIIYYLYTLKLEGERDESATSTTSRLERDIRDLQAVFESEVIPD- 66
            |..|..:|..||.:|   :...:..||.....|...|........|:....||......:...|
Mouse     7 WAGKSCLLLALLTLAYILVEFSVSTLYASPGAGGARELGPRRLPDLDTREEDLSQPLYIKPPADS 71

  Fly    67 --LGALGRPARGNWTEEQLEAIAKSQRET----GYNAWLSKRISPERSLYDMRHRSCKKLKYPME 125
              ||..||.::....|.:|    |.|.|.    ..|.:||.|||..|.:.|.|...||..|:...
Mouse    72 HALGEWGRASKLQLNEGEL----KQQEELIERYAINIYLSDRISLHRHIEDKRMYECKAKKFHYR 132

  Fly   126 KLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEKLNDFIKIK------ 184
            .||:.||:|.::||..|.||||:.|:...:|..||:|:|||||        |:|.|.:|
Mouse   133 SLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDD--------LSDRIYLKAQLETY 189

  Fly   185 FLNMVQHRRITT--QVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTP 247
            ..|:.:.|.|.|  :.||:.||::||..|..|||.|||.|.|...||||||:..|..|......|
Mouse   190 ISNLERVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNTGWLEPLLERISRDETAIVCP 254

  Fly   248 IIDTIDFDNFAY--RRGKPSRGFFNWE--FNYIQLPL-LKEEAVAMPAPHKNPIMNGGLFAIGRE 307
            :|||||::.|.:  :.|:|..|.|:|.  |.:..:|. .::...:...|.::|.|.|||||:.::
Mouse   255 VIDTIDWNTFEFYMQTGEPMIGGFDWRLTFQWHSVPKHERDRRTSRIDPIRSPTMAGGLFAVSKK 319

  Fly   308 WFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKKL 372
            :|..||.||.|:::||.|..|||.::|.|||::...|||.|||:|          .|.....:..
Mouse   320 YFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVF----------PKRAPYARPN 374

  Fly   373 ISRNYRRVAEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLY 437
            ..:|..|.||:|:||||:..:...|.......|:|:|::.|:.||.||.|.|:|.|:   |.||:
Mouse   375 FLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDLSERKLLRERLKCKSFDWYLKNV---FSNLH 436

  Fly   438 PILDPAEYASGVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPSPEQYWSLTNHRELRSGFYC 502
            ...|...: .|.::|:.....|||...|.:.             |:
Mouse   437 VPEDRPGW-HGAIRSMGISSECLDYNAPDNN-------------PT------------------- 468

  Fly   503 LEVRNHGVNVHIYQCHGQSGNQFWS--------FDSKTHQVISGQQQ------------------ 541
                  |.|:.::.||||.||||:.        |:|.|.......||
Mouse   469 ------GANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPQQKDYVGMQNCPKDGLPVPV 527

  Fly   542 ---------------NFRHCL------EAQPELNAVTSSVCDPKNHKQQWKF 572
                           :.|.||      |.:|.::..|   ||..:..|.|:|
Mouse   528 NIIWHFKEDGTIFHPHTRLCLSAYRTAEGRPSVHMKT---CDALDKNQLWRF 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	pp-GalNAc-T	131..430	CDD:133004	119/311 (38%)
		beta-trefoil_Ricin_Pgant8-like	445..573	CDD:467339	33/175 (19%)
Galnt4	NP_056552.1	Catalytic subdomain A	134..243		51/116 (44%)
		pp-GalNAc-T	138..432	CDD:133004	119/314 (38%)
		Catalytic subdomain B	303..365		31/71 (44%)
		beta-trefoil_Ricin-like	442..577	CDD:483949	33/177 (19%)