DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and Galnt4

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_056552.1	Gene:	Galnt4 / 14426	MGIID:	894692	Length:	578	Species:	Mus musculus

Alignment Length:	637	Identity:	193/637 - (30%)
Similarity:	280/637 - (43%)	Gaps:	137/637 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WRHKKKVLPLLLLMA---IGSIIYYLYTLKLEGERDESATSTTSRLERDIRDLQAVFESEVIPD- 66
            |..|..:|..||.:|   :...:..||.....|...|........|:....||......:...|
Mouse     7 WAGKSCLLLALLTLAYILVEFSVSTLYASPGAGGARELGPRRLPDLDTREEDLSQPLYIKPPADS 71

  Fly    67 --LGALGRPARGNWTEEQLEAIAKSQRET----GYNAWLSKRISPERSLYDMRHRSCKKLKYPME 125
              ||..||.::....|.:|    |.|.|.    ..|.:||.|||..|.:.|.|...||..|:...
Mouse    72 HALGEWGRASKLQLNEGEL----KQQEELIERYAINIYLSDRISLHRHIEDKRMYECKAKKFHYR 132

  Fly   126 KLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEKLNDFIKIK------ 184
            .||:.||:|.::||..|.||||:.|:...:|..||:|:|||||        |:|.|.:|
Mouse   133 SLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDD--------LSDRIYLKAQLETY 189

  Fly   185 FLNMVQHRRITT--QVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTP 247
            ..|:.:.|.|.|  :.||:.||::||..|..|||.|||.|.|...||||||:..|..|......|
Mouse   190 ISNLERVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNTGWLEPLLERISRDETAIVCP 254

  Fly   248 IIDTIDFDNFAY--RRGKPSRGFFNWE--FNYIQLPL-LKEEAVAMPAPHKNPIMNGGLFAIGRE 307
            :|||||::.|.:  :.|:|..|.|:|.  |.:..:|. .::...:...|.::|.|.|||||:.::
Mouse   255 VIDTIDWNTFEFYMQTGEPMIGGFDWRLTFQWHSVPKHERDRRTSRIDPIRSPTMAGGLFAVSKK 319

  Fly   308 WFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKKL 372
            :|..||.||.|:::||.|..|||.::|.|||::...|||.|||:|          .|.....:..
Mouse   320 YFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVF----------PKRAPYARPN 374

  Fly   373 ISRNYRRVAEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLY 437
            ..:|..|.||:|:||||:..:...|.......|:|:|::.|:.||.||.|.|:|.|:   |.||:
Mouse   375 FLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDLSERKLLRERLKCKSFDWYLKNV---FSNLH 436

  Fly   438 PILDPAEYASGVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPSPEQYWSLTNHRELRSGFYC 502
            ...|...: .|.::|:.....|||...|.:.             |:
Mouse   437 VPEDRPGW-HGAIRSMGISSECLDYNAPDNN-------------PT------------------- 468

  Fly   503 LEVRNHGVNVHIYQCHGQSGNQFWS--------FDSKTHQVISGQQQ------------------ 541
                  |.|:.::.||||.||||:.        |:|.|.......||
Mouse   469 ------GANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPQQKDYVGMQNCPKDGLPVPV 527

  Fly   542 ---------------NFRHCL------EAQPELNAVTSSVCDPKNHKQQWKF 572
                           :.|.||      |.:|.::..|   ||..:..|.|:|
Mouse   528 NIIWHFKEDGTIFHPHTRLCLSAYRTAEGRPSVHMKT---CDALDKNQLWRF 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	118/311 (38%)
		pp-GalNAc-T	131..430	CDD:133004	119/311 (38%)
		Ricin_B_lectin	446..570	CDD:279046	31/170 (18%)
		RICIN	448..572	CDD:238092	32/170 (19%)
Galnt4	NP_056552.1	WcaA	133..430	CDD:223539	120/314 (38%)
		Catalytic subdomain A	134..243		51/116 (44%)
		pp-GalNAc-T	138..432	CDD:133004	119/314 (38%)
		Catalytic subdomain B	303..365		31/71 (44%)
		RICIN	446..576	CDD:238092	32/170 (19%)
		Ricin_B_lectin	446..574	CDD:279046	31/168 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810