DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and Galnt3

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_056551.2	Gene:	Galnt3 / 14425	MGIID:	894695	Length:	633	Species:	Mus musculus

Alignment Length:	663	Identity:	191/663 - (28%)
Similarity:	310/663 - (46%)	Gaps:	174/663 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HKKKVLPLLL-------LMAIGSIIYYLYTLKLEGERDESA--TSTTSRLERDIRD--------L 55
            |.|:::.|.:       ...:|::|::...:.:..:|:.|.  :...|::||::::        |
Mouse     3 HLKRLVKLHIKRHYHRKFWKLGAVIFFFLVVLILMQREVSVQYSKEESKMERNLKNKNKMLDFML 67

  Fly    56 QAVFE-SEVIPDLGALGRPAR------------GNWTEEQLEAI--------------------- 86
            :||.. .:.:|.: .:|.|.:            |.:|..:|:.:
Mouse    68 EAVNNIKDAMPKM-QIGAPIKENIDVRERPCLQGYYTAAELKPVFDRPPQDSNAPGASGKPFKIT 131

  Fly    87 -----AKSQRETG-----YNAWLSKRISPERSL-YDMRHRSCKKLKYP-MEKLPSVSVVITYHNE 139
                 .:.::|.|     :||:.|.|||..|.| .|.|...|.:.|:. ...||:.||:|.:|||
Mouse   132 HLSPEEQKEKERGETKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNE 196

  Fly   140 EASVLLRTLSSLRSRTPIQLLREVILVDDGSTQ--ADEKLNDFIK----IKFLNMVQHRRITTQV 198
            ..|.||||:.|:...:|..||:|:|||||.|..  ..|||.::||    :|.:.. |.|:
Mouse   197 AWSTLLRTVHSVLYSSPAILLKEIILVDDASVDDYLHEKLEEYIKQFSIVKIVRQ-QERK----- 255

  Fly   199 GLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDFDNFAYRRGK 263
            ||:.||::||.:|.|:.|.|||:|.|...||||||:|.|.|:.....:|.|.:||.:.|.:.:..
Mouse   256 GLITARLLGAAVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPS 320

  Fly   264 P-----SRGFFNW--EFNYIQLP-----LLKEEAVAMPAPHKNPIMNGGLFAIGREWFSELGGYD 316
            |     :||.|:|  .|.:..||     ..|:|..    |.|.|...||||:|.:::|..:|.||
Mouse   321 PYGSNHNRGNFDWSLSFGWESLPDHEKQRRKDETY----PIKTPTFAGGLFSISKKYFEHIGSYD 381

  Fly   317 KGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKK---LISRNYR 378
            :.::|||.|..|:|.::|.||||:..:|||.|||:||         :|..::..|   :|:||..
Mouse   382 EEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFR---------SKSPHTFPKGTQVIARNQV 437

  Fly   379 RVAEIWLDEYKDKLFANMPHLTVI----PVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLY-P 438
            |:||:|:||||:..:........|    ..|:|:::.::|.||.||.|.|:|:   |.:...| |
Mouse   438 RLAEVWMDEYKEIFYRRNTDAAKIVKQKSFGDLSKRFEIKKRLQCKNFTWYLN---TIYPEAYVP 499

  Fly   439 ILDPAEYASGVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPSPEQYWSLTNHRELRSGFYCL 503
            .|:|.  .||.::|:..| ||||..:.:.|
Mouse   500 DLNPV--ISGYIKSVGQP-LCLDVGENNQG----------------------------------- 526

  Fly   504 EVRNHGVNVHIYQCHGQSGNQFWSFDSKTHQVISGQQQNFRHCLEAQPELNA----VTSSVCDPK 564
                 |..:.:|.|||..|||::.:.:         |:..||.::.:..|:|    |....|..|
Mouse   527 -----GKPLILYTCHGLGGNQYFEYSA---------QREIRHNIQKELCLHATQGVVQLKACVYK 577

  Fly   565 NHK------QQWK 571
            .|:      |.|:
Mouse   578 GHRTIAPGEQIWE 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	123/323 (38%)
		pp-GalNAc-T	131..430	CDD:133004	123/323 (38%)
		Ricin_B_lectin	446..570	CDD:279046	27/133 (20%)
		RICIN	448..572	CDD:238092	27/134 (20%)
Galnt3	NP_056551.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..145		1/32 (3%)
		WcaA	184..>302	CDD:223539	55/123 (45%)
		Catalytic subdomain A	184..293		52/114 (46%)
		pp-GalNAc-T	188..493	CDD:133004	124/326 (38%)
		Catalytic subdomain B	356..418		29/61 (48%)
		Ricin_B_lectin	506..627	CDD:279046	28/135 (21%)
		RICIN	507..629	CDD:238092	27/134 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810