DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and Galnt1

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001153876.1	Gene:	Galnt1 / 14423	MGIID:	894693	Length:	559	Species:	Mus musculus

Alignment Length:	528	Identity:	183/528 - (34%)
Similarity:	277/528 - (52%)	Gaps:	63/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GALGRPARGNWTEEQLEAIAKSQRETGYNAWLSKRISPERSLYDMRHRSCKKLKYPMEKLPSVSV 132
            |.:|:|.  ...:|..|.:.:..:...:|...|:.|:..|||.|:|...||...|| :.||:.||
Mouse    59 GEMGKPV--VIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYP-DNLPTTSV 120

  Fly   133 VITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEKLNDFIK------IKFLNMVQH 191
            ||.:|||..|.||||:.|:.:|:|..::.|::||||.|.:      ||:|      :|.|.:..|
Mouse   121 VIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASER------DFLKRPLESYVKKLKVPVH 179

  Fly   192 -RRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDFD 255
             .|:..:.||:.||:.||.::...|:.|||:|.|.|.||||||:|.|..|.||...||||.|..|
Mouse   180 VIRMEQRSGLIRARLKGAAVSRGQVITFLDAHCECTAGWLEPLLARIKHDRRTVVCPIIDVISDD 244

  Fly   256 NFAYRRGKP-SRGFFNWEFNYIQLPLLKEEAVAMPA----PHKNPIMNGGLFAIGREWFSELGGY 315
            .|.|..|.. :.|.|||:.|:...|:.:.|......    |.:.|.|.||||:|.|::|.|:|.|
Mouse   245 TFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTY 309

  Fly   316 DKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKKLISRNYRRV 380
            |.|:.|||.|..|:|.::|.|||.:..|.||.|||:||...   .||......:  :|::|.||:
Mouse   310 DAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKAT---PYTFPGGTGQ--IINKNNRRL 369

  Fly   381 AEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLYPILD-PAE 444
            ||:|:||:|:..:...|.:|.:..|:::.:..|:.:|.||||.|:|:       |:||... |..
Mouse   370 AEVWMDEFKNFFYIISPGVTKVDYGDISSRLGLRRKLQCKPFSWYLE-------NIYPDSQIPRH 427

  Fly   445 YAS-GVLQSISSPKLCLD---RKDPS-------HGQPKLAPCSSDHVFPSPEQYWSLTNHRELRS 498
            |.| |.::::.:.: |||   ||:..       ||.             ...|.:|.|.::|:|:
Mouse   428 YFSLGEIRNVETNQ-CLDNMARKENEKVGIFNCHGM-------------GGNQVFSYTANKEIRT 478

  Fly   499 GFYCLEVRNHGVNVHIYQCHGQSGNQFWSFDSKTHQVISGQQQNFRHCLEAQPELNAVTSSVCD- 562
            ...||:|......|.:.:||...|||.|.:|...   ::.|..|...||:...|.::...|:.|
Mouse   479 DDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVK---LTLQHVNSNQCLDKATEEDSQVPSIRDC 540

  Fly   563 PKNHKQQW 570
            ..:..|||
Mouse   541 TGSRSQQW 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	124/310 (40%)
		pp-GalNAc-T	131..430	CDD:133004	124/310 (40%)
		Ricin_B_lectin	446..570	CDD:279046	33/135 (24%)
		RICIN	448..572	CDD:238092	34/134 (25%)
Galnt1	NP_001153876.1	Catalytic subdomain A	115..225		49/115 (43%)
		pp-GalNAc-T	119..419	CDD:133004	125/317 (39%)
		Catalytic subdomain B	285..347		31/61 (51%)
		Ricin_B_lectin	432..548	CDD:306998	32/132 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810