DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and GALNT15

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_473451.3	Gene:	GALNT15 / 117248	HGNCID:	21531	Length:	639	Species:	Homo sapiens

Alignment Length:	674	Identity:	200/674 - (29%)
Similarity:	305/674 - (45%)	Gaps:	147/674 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WRHKK-KVLPLLLLMAIGSIIYYL-------YTLKLEGERDESATSTTSRLERDIRD-----LQA 57
            :||:. ::..||||:.:|.::..:       :||........|..|..:|...|..:     |:|
Human     7 YRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTVTAQASKHSPEARYRLDFGESQDWVLEA 71

  Fly    58 VFESEVIPDLGAL--------------------------GR------------------PARGNW 78
            ..|.|....|..|                          ||                  |.| :|
Human    72 EDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLIKQPRRQDKEAPKR-DW 135

  Fly    79 ---------TEEQLEAIAKSQRETGYNAWLSKRISPERSLYDMRHRSCKKLKYPMEKLPSVSVVI 134
                     .||:|...:...|  |....||.||..:|:|.::||..|.: ::|.:.||:.||::
Human   136 GADEDGEVSEEEELTPFSLDPR--GLQEALSARIPLQRALPEVRHPLCLQ-QHPQDSLPTASVIL 197

  Fly   135 TYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEK--LNDFIK----IKFLNMVQHRR 193
            .:|:|..|.||||:.|:....|...|:|:|||||.|.|...|  |::::.    :|.|      |
Human   198 CFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKSALSEYVARLEGVKLL------R 256

  Fly   194 ITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDFDNFA 258
            ...::|.:.||::||..|..|||||:|:|.|...||||||::.|..|.....:|:||.||:..|.
Human   257 SNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQ 321

  Fly   259 YRRGKP-SRGFFNW--EFNYIQLPLLKEEAVAMP-APHKNPIMNGGLFAIGREWFSELGGYDKGL 319
            |...|. .||..:|  :|::..||....:|:..| :|.::|::.|.:.|:.|.:|...|.||..:
Human   322 YYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLM 386

  Fly   320 KIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNS--EKKLISRNYRRVAE 382
            .:.|.|..|||.|.|||||.:..:|||||||:         |.|:|.:|  :::...||..|:||
Human   387 SLRGGENLELSFKAWLCGGSVEILPCSRVGHI---------YQNQDSHSPLDQEATLRNRVRIAE 442

  Fly   383 IWLDEYKDKLFANMPH---LTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLYPILDPAE 444
            .||..:|:..:.:.|.   |:.....:..|:..|:.||.|:.|.|||.|:   :..||| .:|..
Human   443 TWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRLGCRTFHWFLANV---YPELYP-SEPRP 503

  Fly   445 YASGVLQSISSPKLCLDRKDPSH--GQPK-LAPCSSDHVFPSPEQYWSLTNHRELRSG---FYCL 503
            ..||.|.: :...||.|.:....  |.|. |||||...    .:||...|:.:|:..|   ..|.
Human   504 SFSGKLHN-TGLGLCADCQAEGDILGCPMVLAPCSDSR----QQQYLQHTSRKEIHFGSPQHLCF 563

  Fly   504 EVR----------NHGVNVHIYQCHGQSGNQFWSFDSK---THQVISGQQQNFRHCLEA--QPEL 553
            .||          ..|:.:|         .|.|.|...   .| ::||:      |:||  |...
Human   564 AVRQEQVILQNCTEEGLAIH---------QQHWDFQENGMIVH-ILSGK------CMEAVVQENN 612

  Fly   554 NAVTSSVCDPKNHKQQWKFGYLNS 577
            ..:....||.| .:|||:|..:|:
Human   613 KDLYLRPCDGK-ARQQWRFDQINA 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	113/313 (36%)
		pp-GalNAc-T	131..430	CDD:133004	114/313 (36%)
		Ricin_B_lectin	446..570	CDD:279046	37/144 (26%)
		RICIN	448..572	CDD:238092	38/144 (26%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..155		8/49 (16%)
		Catalytic subdomain A	190..299		47/114 (41%)
		Glyco_tranf_2_3	191..447	CDD:290369	102/270 (38%)
		pp-GalNAc-T	194..493	CDD:133004	114/316 (36%)
		Catalytic subdomain B	358..420		27/70 (39%)
		Ricin_B_lectin	505..628	CDD:279046	37/144 (26%)
		RICIN	507..630	CDD:238092	38/144 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152480
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740