Protein Alignment Pgant8 and Galnt2

DIOPT Version :10

• Sequence 1: NP_648800.1
• Gene: Pgant8 / 39715
• FlyBaseID: FBgn0036529
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_644678.2
• Gene: Galnt2 / 108148
• MGIID: 894694
• Length: 570
• Species: Mus musculus
• Alignment Length: 609
• Identity: 201/609 - (33%)
• Similarity: 308/609 - (50%)
• Gaps: 77/609 - (12%)

  Fly     7 RHKKKVLPLLLLMAIGSIIYYLYTLKLEGERDESATSTTSRLERDIRDLQAVFESEVIPDLG--- 68
            |..:.:|...||..:| |.||:|:   .|....:|....:..:.|..|:.::.:.::....|
Mouse     3 RRSRMLLCFALLWVLG-IAYYMYS---GGGSALAAGGGGAGRKGDWNDIDSIKKKDLHHSRGDEK 63

  Fly    69 ALG----RPARGNWTEEQLEA-----IAKSQRE----TGYNAWLSKRISPERSLYDMRHRSCKKL 120
            |.|    .|.:..|.:...||     :.:|.::    ..:|...|.::..:|.:.|.||..|::.
Mouse    64 AQGVETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLHMDRGIPDTRHDQCQRK 128

  Fly   121 KYPMEKLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADE--KLNDFIKI 183
            ::.:: ||:.|||||:|||..|.||||:.|:..|:|..|::|:|||||.|...::  .|....|:
Mouse   129 QWRVD-LPATSVVITFHNEARSALLRTVVSVLKRSPPHLIKEIILVDDYSNDPEDGALLGKIEKV 192

  Fly   184 KFLNMVQHRRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPI 248
            :.|      |...:.|||.:||.||:.|.|.||.|||||.|..:.|||||:..:.||.....:||
Mouse   193 RVL------RNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNERWLEPLLERVAEDRTRVVSPI 251

  Fly   249 IDTIDFDNFAYRRGKPS-RGFFNW----EFNYIQLPLLKEEAVAMP-APHKNPIMNGGLFAIGRE 307
            ||.|:.|||.|...... :|.|:|    :::|: .|..:......| ||.|.|::.||||.:.:.
Mouse   252 IDVINMDNFQYVGASADLKGGFDWNLVFKWDYM-TPEQRRSRQGNPVAPIKTPMIAGGLFVMDKL 315

  Fly   308 WFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKKL 372
            :|.|||.||..:.:||.|..|:|.::|.|||.:..:|||||||:||.   |..||  .......:
Mouse   316 YFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRK---QHPYT--FPGGSGTV 375

  Fly   373 ISRNYRRVAEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLY 437
            .:||.||.||:|:||||...:|.:|....:|.||:..:.:|:.:|.||||||:||       |:|
Mouse   376 FARNTRRAAEVWMDEYKHFYYAAVPSARNVPYGNIQSRLELRKKLGCKPFKWYLD-------NVY 433

  Fly   438 PIL---DPAEYASGVLQSISSPKLCLDRKDP-SHGQPKLAPCSSDHVFPSPEQYWSLTNHRELRS 498
            |.|   |..:.|.|.||..::   |||.... :.|...:..|.:    ....|.|:||..:.::.
Mouse   434 PELRVPDHQDIAFGALQQGTN---CLDTLGHFADGVVGIYECHN----AGGNQEWALTKEKSVKH 491

  Fly   499 GFYCLEV--RNHGVNVHIYQCHGQSGNQFWSFDSKTHQVISGQQQNFRH-----CLEAQ-PELNA 555
            ...||.|  |:.|..:.:..|......|.|       :.|.|..: .||     ||::: .:...
Mouse   492 MDLCLTVVDRSPGSLIRLQGCRENDSRQKW-------EQIEGNSK-LRHVGSNLCLDSRTAKSGG 548

  Fly   556 VTSSVCDPKNHKQQWKFGYLNSQR 579
            ::..||.|. ..|||||. ||.|:
Mouse   549 LSVEVCGPA-LSQQWKFS-LNLQQ 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	pp-GalNAc-T	131..430	CDD:133004	128/306 (42%)
		beta-trefoil_Ricin_Pgant8-like	445..573	CDD:467339	34/136 (25%)
Galnt2	NP_644678.2	Catalytic subdomain A	134..239		52/110 (47%)
		pp-GalNAc-T	138..433	CDD:133004	129/313 (41%)
		Catalytic subdomain B	299..361		29/61 (48%)
		beta-trefoil_Ricin_GALNT2	445..564	CDD:467312	33/134 (25%)