DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and Galnt6

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001165534.1	Gene:	Galnt6 / 100361647	RGDID:	2319726	Length:	622	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	185/548 - (33%)
Similarity:	283/548 - (51%)	Gaps:	83/548 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GALGRP-ARGNWTEEQLEAIAKSQRETGY-----NAWLSKRISPERSL-YDMRHRSCKKLKY-PM 124
            ||.|:. .:..||     .:...:::.||     ||:.|.|||.:||| .|.|...|...|: ..
  Rat   114 GADGKAFQKKEWT-----LLETQEKDEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRC 173

  Fly   125 EKLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEKLNDFIKIKFLNMV 189
            ..||:.||||.:|||..|.||||:.|:...:|..||:|:|||||.||  ||.|.:.:: :::..:
  Rat   174 PPLPTTSVVIVFHNEAWSTLLRTVYSVLHTSPAILLKEIILVDDAST--DEHLKEKLE-RYVQQL 235

  Fly   190 QHRRITTQ---VGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDT 251
            |..|:..|   .||:.||::||.:|.|:||.|||:|.|...||||||:|.|.||.....:|.|.|
  Rat   236 QIVRVVRQQERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTAVVSPDIVT 300

  Fly   252 IDFDNFAY----RRGKP-SRGFFNWE--FNYIQLP-----LLKEEAVAMPAPHKNPIMNGGLFAI 304
            ||.:.|.:    ||||. |||.|:|.  |.:..||     ..|:|..    |.|:|...||||:|
  Rat   301 IDLNTFQFSKPMRRGKAHSRGNFDWSLTFGWEMLPEHEKQRRKDETY----PIKSPTFAGGLFSI 361

  Fly   305 GREWFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSE 369
            .:.:|..:|.||..::|||.|..|:|.::|.||||:..:|||.|||:||         .|..::.
  Rat   362 SKAYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFR---------TKSPHTF 417

  Fly   370 KK---LISRNYRRVAEIWLDEYKDKLF--ANMPHLTVIP---VGNLAEQRDLKNRLHCKPFKWFL 426
            .|   :|:||..|:||:|:|:|| |:|  .|:....:..   .|:::|:..|:.:|||..|.|:|
  Rat   418 PKGTSVIARNQVRLAEVWMDDYK-KIFYRRNLQAAKMAKENNFGDVSERLRLREQLHCHNFSWYL 481

  Fly   427 DNLATDFLNLYPILDPAEYASGVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPSPEQYWSLT 491
            .|:..:.  ..|.|:|.  .||.::::.:.: |||..:.:.|...|......::  ...||:..|
  Rat   482 HNVYPEM--FVPDLNPT--FSGAIKNLGTSQ-CLDVGENNRGGKPLIMYVCHNL--GGNQYFEYT 539

  Fly   492 NHRELRSGF---YCLEVRNHGVNVHIYQCHGQSG----NQFWSFDSKTHQVISGQQQNFRH---- 545
            :.|:||...   .||......:.:...|..|::.    ::.|...         |.|..|:
  Rat   540 SQRDLRHNIGKQLCLHASGSTLGLRNCQFIGKNSEVPKDEEWELT---------QDQLIRNLGSG 595

  Fly   546 -CLEAQPELNAVTSSVCDPKNHKQQWKF 572
             ||.::.:..|:  :.|:|.:..|.|.|
  Rat   596 TCLTSKDKKPAM--APCNPSDPYQLWLF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	130/321 (40%)
		pp-GalNAc-T	131..430	CDD:133004	131/321 (41%)
		Ricin_B_lectin	446..570	CDD:279046	27/135 (20%)
		RICIN	448..572	CDD:238092	27/135 (20%)
Galnt6	NP_001165534.1	pp-GalNAc-T	180..485	CDD:133004	131/321 (41%)
Galnt6	NP_001165534.1	Ricin_B_lectin	497..619	CDD:395527	27/135 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840