DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7579 and GALNT11

DIOPT Version :9

Sequence 1:	NP_648799.1	Gene:	CG7579 / 39714	FlyBaseID:	FBgn0036528	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001358393.1	Gene:	GALNT11 / 63917	HGNCID:	19875	Length:	667	Species:	Homo sapiens

Alignment Length:	482	Identity:	147/482 - (30%)
Similarity:	232/482 - (48%)	Gaps:	70/482 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DAQLQN---EKYQYNAWLSERIPLKRTLEDYRDPQCLKINYSSEKTVTVSIVIAIQQEHPHTLLR 69
            |.:|::   :|:.:|..:|:|:...|.:.|.|:..| |..:........|:||....|....|||
Human   106 DQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAAC-KEKFYPPDLPAASVVICFYNEAFSALLR 169

  Fly    70 GIYSVITQTSPYLLKEIVLVHD--------GHPDLDLIRHIHHKLPIVIQLEMESSKGIIHARLT 126
            .::|||.:|..:||.||:||.|        |..|..:.:::..|:.::...:.|   |:|..|:.
Human   170 TVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKRE---GLIRGRMI 231

  Fly   127 GAGVATGDILVFLNGHMEVTRGWLPPLLEPILLNNQTVTEPIVDAISRESFAYRKLVEP-EQLAF 190
            ||..|||::||||:.|.||...||.|||..|..:..||..|::|.||.::.||..  .| .:..|
Human   232 GAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSS--SPVVRGGF 294

  Fly   191 DWQLDHIFLPLDQHSWNSLP-----------KPYPSSQLEGRVFAIDRKWFWHLGGWDEGLRDYG 244
            :|.|        ...|:.:|           .|..|..:.|.:||::|::|..||.:|.|:..:|
Human   295 NWGL--------HFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWG 351

  Fly   245 GDALELSLKVWQCGGLILAVPCSRVGIIYKRDELEAQMAPNRNPSLQ--VQKNFKRVVDVWLDEY 307
            |:.||:|.::|.|||.:..:||||||.|:::      ..|..:|..|  :..|..|:..||||||
Human   352 GENLEISFRIWMCGGKLFIIPCSRVGHIFRK------RRPYGSPEGQDTMTHNSLRLAHVWLDEY 410

  Fly   308 KLHFYRYNPKLRNLTAESLDKPRDLRRRLNCKSFEWYRSQVAPQIRNHFLHAGLTNYPI----GK 368
            |..::...|.|:..:..::.:..:||::|.||||:||...|.|:::....|| ....||    |.
Human   411 KEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHA-KPQQPIFVNRGP 474

  Fly   369 IMPFVAP-----HF----CL------SIKGGFPVIRKC-HSTNFEDWTLTSRCQL-KHGNMCLDV 416
            ..|.|..     |.    ||      |.|||..|::.| :|...:.|......:| .:..:|||:
Human   475 KRPKVLQRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDM 539

  Fly   417 DYKNN---VRATKCTKKLSKNPWHYNY 440
            ....:   .|..||........|.:.|
Human   540 SETRSSDPPRLMKCHGSGGSQQWTFGY 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7579	NP_648799.1	WcaA	52..336	CDD:223539	100/305 (33%)
		pp-GalNAc-T	54..349	CDD:133004	107/316 (34%)
		RICIN	367..478	CDD:238092	23/94 (24%)
		Ricin_B_lectin	373..476	CDD:279046	21/88 (24%)
GALNT11	NP_001358393.1	Catalytic subdomain A	150..261		42/113 (37%)
		pp-GalNAc-T	154..452	CDD:133004	107/316 (34%)
		Catalytic subdomain B	319..381		27/61 (44%)
		Ricin_B_lectin	483..>564	CDD:366226	19/80 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740