DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7579 and GALNT7

DIOPT Version :9

Sequence 1:	NP_648799.1	Gene:	CG7579 / 39714	FlyBaseID:	FBgn0036528	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001362528.1	Gene:	GALNT7 / 51809	HGNCID:	4129	Length:	657	Species:	Homo sapiens

Alignment Length:	523	Identity:	164/523 - (31%)
Similarity:	248/523 - (47%)	Gaps:	86/523 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QLQNEKYQYNAWLSERIPLKRTLEDYRDPQCLKINYSSEKTVTVSIVIAIQQEHPHTLLRGIYSV 74
            |...:::.:|...|:.|.|.|::.|.|..:|...:| .|..:|.|:||....|...||:|.::||
Human   167 QASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHY-DENLLTSSVVIVFHNEGWSTLMRTVHSV 230

  Fly    75 ITQTSPYLLKEIVLVHDGHPDLDLIRHIHHKLPIVIQL--------EMESSKGIIHARLTGAGVA 131
            |.:|....|.||||:    .|.....|:..||...|:|        ..|..:|:|.||..||..|
Human   231 IKRTPRKYLAEIVLI----DDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKA 291

  Fly   132 -TGDILVFLNGHMEVTRGWLPPLLEPILLNNQTVTEPIVDAISRESFAYRKLVEPEQ-------- 187
             .|.:|::|:.|.||...|..||:.||..:..|.|.|::|.|....::    :||:|
Human   292 KLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTTCTVPLIDYIDGNDYS----IEPQQGGDEDGFA 352

  Fly   188 -LAFDWQLDHIFLPLDQHSWNSLP-------------KPYPSSQLEGRVFAIDRKWFWHLGGWDE 238
             .|:||.|          .|..:|             :||.|..:.|.:|||:|::|:.||.:|.
Human   353 RGAWDWSL----------LWKRIPLSHKEKAKRKHKTEPYRSPAMAGGLFAIEREFFFELGLYDP 407

  Fly   239 GLRDYGGDALELSLKVWQCGGLILAVPCSRVGIIYKRDELEAQMAP---NRNPSLQVQKNFKRVV 300
            ||:.:||:..|:|.|:|||||.:|.|||||||.||:.:..:....|   ..:|:|   ||:.|||
Human   408 GLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTL---KNYVRVV 469

  Fly   301 DVWLDEYKLHFYRYNPKLRNLTAESLDKPRDLRRRLNCKSFEWYRSQVAPQIRNHFLHAGLTNYP 365
            :||.||||.:||...|:.:.|....:.:.:..|...|||||:|:..::|..|.:|        ||
Human   470 EVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSH--------YP 526

  Fly   366 I-------GKIMPFVAPHFCL----SIKGGFPVIRKCHSTNFED-WTLTSRCQLKHGNMCLDVDY 418
            :       |:|..|... :|:    ...|||..:..||...... :.:....||...:.||....
Human   527 LPPKNVDWGEIRGFETA-YCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGA 590

  Fly   419 K-NNVRATKCTKKLSKNPWHY--NYQHSSFVSNGNKCLQIDVNKV--GLILSACDSDVTEQRWMF 478
            . :.|..|.|.....|. |.|  |....:.:.:| |||  |.::|  .:.:|.|||..|.|:|..
Human   591 DGSKVMITHCNLNEFKE-WQYFKNLHRFTHIPSG-KCL--DRSEVLHQVFISNCDSSKTTQKWEM 651

  Fly   479 TKV 481
            ..:
Human   652 NNI 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7579	NP_648799.1	WcaA	52..336	CDD:223539	109/317 (34%)
		pp-GalNAc-T	54..349	CDD:133004	114/328 (35%)
		RICIN	367..478	CDD:238092	33/120 (28%)
		Ricin_B_lectin	373..476	CDD:279046	29/112 (26%)
GALNT7	NP_001362528.1	pp-GalNAc-T	210..518	CDD:133004	114/328 (35%)
GALNT7	NP_001362528.1	Ricin_B_lectin	534..649	CDD:366226	32/119 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810