DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7579 and GALNT5

DIOPT Version :9

Sequence 1:	NP_648799.1	Gene:	CG7579 / 39714	FlyBaseID:	FBgn0036528	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_016858726.1	Gene:	GALNT5 / 11227	HGNCID:	4127	Length:	956	Species:	Homo sapiens

Alignment Length:	532	Identity:	162/532 - (30%)
Similarity:	257/532 - (48%)	Gaps:	92/532 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DAQLQNEKYQYNAWLSERIPLKRTLEDYRDPQCLKINYSSEKTV-----TVSIVIAIQQEHPHTL 67
            :|:.:.::..:|.:||:.||:.|.:||.|...|      :|:.|     |.|:::....|...||
Human   454 EAERRWKEGNFNVYLSDLIPVDRAIEDTRPAGC------AEQLVHNNLPTTSVIMCFVDEVWSTL 512

  Fly    68 LRGIYSVITQTSPYLLKEIVLVHD-GHPDL--DLIRHIHHKLPIVIQLEMESSKGIIHARLTGAG 129
            ||.::|||.::.|:|:|||:||.| ...|.  |.:.....:.|.|..|.::...|:|.|||.||.
Human   513 LRSVHSVINRSPPHLIKEILLVDDFSTKDYLKDNLDKYMSQFPKVRILRLKERHGLIRARLAGAQ 577

  Fly   130 VATGDILVFLNGHMEVTRGWLPPLLEPILLNNQTVTEPIVDAISRESFAYRKLVEPEQLAFDWQL 194
            .||||:|.||:.|:|...|||.||||.:.|:.:.|..|:::.|:.:..:|..:...::..|.|.:
Human   578 NATGDVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVINDKDMSYMTVDNFQRGIFVWPM 642

  Fly   195 DHIFLPLDQHSWNSLPKPYPSSQ------------LEGRVFAIDRKWFWHLGGWDEGLRDYGGDA 247
            :        ..|.::|....:..            :.|.:|:||:.:|:.||.:|.||..:||:.
Human   643 N--------FGWRTIPPDVIAKNRIKETDTIRCPVMAGGLFSIDKSYFFELGTYDPGLDVWGGEN 699

  Fly   248 LELSLKVWQCGGLILAVPCSRVGIIYKRDELEAQMAPNRNP-------SLQVQKNFKRVVDVWLD 305
            :|||.|||.|||.|..:||||||.|::.|          ||       ...|::|..||.:||||
Human   700 MELSFKVWMCGGEIEIIPCSRVGHIFRND----------NPYSFPKDRMKTVERNLVRVAEVWLD 754

  Fly   306 EYKLHFYRYNPKL--RNLTAESLDKPRDLRRRLNCKSFEWYRSQVAPQIRNHFLHAG--LTNYPI 366
            |||..||.:...|  :.|...:|.:.|:||::|.||||:||...|.|.:|...:.|.  |.|..:
Human   755 EYKELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCKSFKWYLENVFPDLRAPIVRASGVLINVAL 819

  Fly   367 GKIMPFVAPHFCLSIKGGFPVIRKCH-STNFEDWTLTSRCQLKHGNMCL-DVDYKNNVRATKCTK 429
            ||         |:||:....::..|. |...:.:..|....:|.|..|: .:..|..||...|..
Human   820 GK---------CISIENTTVILEDCDGSKELQQFNYTWLRLIKCGEWCIAPIPDKGAVRLHPCDN 875

  Fly   430 KLSKNPWHY---NYQHSSFVSN--------------------GNK---CLQIDVNKVGLILSACD 468
            :.....|.:   :..|...:||                    .|:   ||:.:.::..|.::|||
Human   876 RNKGLKWLHKSTSVFHPELLSNSACGSFPALLSLQVNHIVFENNQQLLCLEGNFSQKILKVAACD 940

  Fly   469 SDVTEQRWMFTK 480
            .....|:|.|.|
Human   941 PVKPYQKWKFEK 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7579	NP_648799.1	WcaA	52..336	CDD:223539	106/307 (35%)
		pp-GalNAc-T	54..349	CDD:133004	112/318 (35%)
		RICIN	367..478	CDD:238092	28/138 (20%)
		Ricin_B_lectin	373..476	CDD:279046	25/130 (19%)
GALNT5	XP_016858726.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810