Protein Alignment CG7304 and GALNT12

DIOPT Version :10

• Sequence 1: NP_996098.1
• Gene: CG7304 / 39713
• FlyBaseID: FBgn0036527
• Length: 563
• Species: Drosophila melanogaster
• Sequence 2: NP_078918.3
• Gene: GALNT12 / 79695
• HGNCID: 19877
• Length: 581
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 147/528 - (27%)
• Similarity: 238/528 - (45%)
• Gaps: 83/528 - (15%)

  Fly    41 PLSHPGLGENGSASYLSVPSWEIDEYTQGWRYYLYNSWLAERIPLRRSLPDLRDHRCQKLEYDED 105
            |:....||..|.|..|.:...|:....:..|.:..|.:|::||.|.|.||:..:..|::.:||.|
Human    69 PVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYD 133

  Fly   106 SDEMKPASIIMIFRNEQLVVLLRTLHSLVERTPKYLYIELILVNDHSDTDFWNDKLSLIFFDNYV 170
            :  :...|:|:.|.||....||||::|::|.:|..|..|:|||:|:||.:...::|:     |.:
Human   134 N--LPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLA-----NEL 191

  Fly   171 HRYIHPKARILHLPEQVGLIKARNLAASEAKAENLVFVDAQVEFTNGWLSPLLDTIAEQSYTLAT 235
            ...  ||.|::...::.||::||.|.||.|:.:.|.|:|...|...|||.|||..|.|:...:..
Human   192 SGL--PKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVC 254

  Fly   236 PILDNLDEQTLAY--QRSIERRGMYDWSL--TRREVPLSRARRSHLPWPYEVAAVRT---SVFAI 293
            |::|.:|..|..|  .....:.|.:||.|  |...||  ...|..:..|.:|....|   .:||:
Human   255 PVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVP--ERERIRMQSPVDVIRSPTMAGGLFAV 317

  Fly   294 PAVWFQDISNFDNNLRGFGAAELELSFKVWCTGGRIVQVPCSRVGHLQPKDEDYLKRYGDLHKMG 358
            ...:|:.:.::|..:..:|...||.||::|..||.:...|||.|||:.||...|.:
Human   318 SKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSR--------- 373

  Fly   359 EQKSRNLKRIIEVWTGDLKSAIYKYQPHLLNISEGDLNEPRKLYKQNECQSFKEFINDITPGLNH 423
            .:...|..|..|||..:.|...|...|.......||:.|.::|..:.:|:.||.|:..:.|.|
Human   374 NKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPEL-- 436

  Fly   424 VAALNRTDYASGHVKTLEFPKKCLTINAKSQNLFLERCSTNNTLQNWTLTYVKDLRVAGNICAEV 488
                        ||     |:              :|......|||..||         :.|.:.
Human   437 ------------HV-----PE--------------DRPGFFGMLQNKGLT---------DYCFDY 461

  Fly   489 RP---NLRLGYS----FCHSLGGRQSWHYDSVSNQLMSNTK----CLEFTDELN-IFLAIC-DAA 540
            .|   |..:|:.    .||.:|..|.:.|.| ..::..||.    |:.....:: :.:.:| :.|
Human   462 NPPDENQIVGHQVILYLCHGMGQNQFFEYTS-QKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETA 525

  Fly   541 NGKQRWIL 548
            ...|::||
Human   526 PENQKFIL 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7304	NP_996098.1	pp-GalNAc-T	113..417	CDD:133004	98/310 (32%)
		beta-trefoil_Ricin_Pgant8-like	432..549	CDD:467339	27/130 (21%)
GALNT12	NP_078918.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..67
		Catalytic subdomain A	135..244		43/115 (37%)
		pp-GalNAc-T	139..433	CDD:133004	98/311 (32%)
		Catalytic subdomain B	304..366		20/61 (33%)
		beta-trefoil_Ricin_GALNT12	443..579	CDD:467349	23/101 (23%)