DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7304 and Galnt1

DIOPT Version :9

Sequence 1:	NP_996098.1	Gene:	CG7304 / 39713	FlyBaseID:	FBgn0036527	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_077349.1	Gene:	Galnt1 / 79214	RGDID:	620358	Length:	559	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	160/573 - (27%)
Similarity:	282/573 - (49%)	Gaps:	52/573 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FKY--IVLP---VWIFIVLLLL-------------HRDLSSWDGL-MGPLSHPGLGENGSASYLS 57
            |.|  :||.   ||:.:.:.||             .|.|.:.|.| :....|.|.||.|..  :.
  Rat     4 FAYCKVVLATSLVWVLLDMFLLLYFSECNKCEEKKERGLPAGDVLELVQKPHEGPGEMGKP--VV 66

  Fly    58 VPSWEIDEYTQGWRYYLYNSWLAERIPLRRSLPDLRDHRCQKLEYDEDSDEMKPASIIMIFRNEQ 122
            :|..:.::..:.::...:|...:|.|...|||||:|...|:...|   .|.:...|::::|.||.
  Rat    67 IPKEDQEKMKEMFKINQFNLMASEMIAFNRSLPDVRLEGCKTKVY---PDSLPTTSVVIVFHNEA 128

  Fly   123 LVVLLRTLHSLVERTPKYLYIELILVNDHSDTDFWNDKLSLIFFDNYVHRYIHPKARILHLPEQV 187
            ...||||:||::.|:|:::..|::||:|.|:.||....|     ::||.:...| ..::.:.::.
  Rat   129 WSTLLRTVHSVINRSPRHMIEEIVLVDDASERDFLKRPL-----ESYVKKLKVP-VHVIRMEQRS 187

  Fly   188 GLIKARNLAASEAKAENLVFVDAQVEFTNGWLSPLLDTIAEQSYTLATPILDNLDEQTLAYQRSI 252
            |||:||...|:.:|.:.:.|:||..|.|.|||.|||..|.....|:..||:|.:.:.|..|....
  Rat   188 GLIRARLKGAAVSKGQVITFLDAHCECTVGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGS 252

  Fly   253 ERR-GMYDWSLTRREVPLSR----ARRSHLPWPYEVAAVRTSVFAIPAVWFQDISNFDNNLRGFG 312
            :.. |.::|.|..|..|:.:    .|:.....|.....:...:|:|...:||:|..:|..:..:|
  Rat   253 DMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWG 317

  Fly   313 AAELELSFKVWCTGGRIVQVPCSRVGHLQPKDEDYLKRYGDLHKMGEQKSRNLKRIIEVWTGDLK 377
            ...||:||::|..||.:..|.||.|||:..|...|....|    .|:..::|.:|:.|||..:.|
  Rat   318 GENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGG----TGQIINKNNRRLAEVWMDEFK 378

  Fly   378 SAIYKYQPHLLNISEGDLNEPRKLYKQNECQSFKEFINDITPGLNHVAALNRTDYASGHVKTLEF 442
            :..|...|.:..:..||::....|..:.:|:.|..::.:|.|.    :.:.|..::.|.::.:|
  Rat   379 NFFYIISPGVTKVDYGDISSRVGLRHKLQCKPFSWYLENIYPD----SQIPRHYFSLGEIRNVE- 438

  Fly   443 PKKCLTINAKSQN--LFLERCSTNNTLQNWTLTYVKDLRVAGNICAEV-RPNLRLGYSFCHSLGG 504
            ..:||...|:.:|  :.:..|......|.::.|..|::| ..::|.:| :.|..:....||.|.|
  Rat   439 TNQCLDNMARKENEKVGIFNCHGMGGNQVFSYTANKEIR-TDDLCLDVSKLNGPVTMLKCHHLKG 502

  Fly   505 RQSWHYDSV--SNQLMSNTKCLE-FTDELNIFLAICDAANGK-QRWILDNINL 553
            .|.|.||.|  :.|.:::.:||: .|:|.:...:|.|....: |:|:|.|:.|
  Rat   503 NQLWEYDPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCTGSRSQQWLLRNVTL 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7304	NP_996098.1	WcaA	108..>231	CDD:223539	42/122 (34%)
		pp-GalNAc-T	113..417	CDD:133004	92/308 (30%)
		Ricin_B_lectin	433..546	CDD:279046	31/119 (26%)
		RICIN	435..548	CDD:238092	32/119 (27%)
Galnt1	NP_077349.1	Catalytic subdomain A	115..225		41/115 (36%)
		pp-GalNAc-T	119..419	CDD:133004	92/309 (30%)
		Catalytic subdomain B	285..347		21/61 (34%)
		Ricin_B_lectin	432..548	CDD:395527	31/117 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810