DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7304 and galntl6

DIOPT Version :9

Sequence 1:	NP_996098.1	Gene:	CG7304 / 39713	FlyBaseID:	FBgn0036527	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001139074.1	Gene:	galntl6 / 568915	ZFINID:	ZDB-GENE-090312-115	Length:	600	Species:	Danio rerio

Alignment Length:	559	Identity:	168/559 - (30%)
Similarity:	267/559 - (47%)	Gaps:	51/559 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLHRDLSSWDGLMGPLSHPGLGENGSASYLSVPSWEIDEYTQGWRYYLYNSWLAERIPLRRSLPD 91
            |..||...::.:.......|.||:|....|.....:...|.:..    :|.:::..|.|.|||||
Zfish    63 LRRRDWHDYESIRKDGQRVGKGEHGKPYPLVEDECDDSVYKENG----FNIYVSNNIALDRSLPD 123

  Fly    92 LRDHRCQKLEYDEDSDEMKPASIIMIFRNEQLVVLLRTLHSLVERTPKYLYIELILVNDHSDTDF 156
            :|...|::..|.|:   :...|||:.|.||....|||||||:..|||.:|..|:|||:|:||.:.
Zfish   124 IRHPNCKQKLYLEN---LPNTSIIIPFHNEGWSSLLRTLHSISNRTPDHLIAEIILVDDYSDREH 185

  Fly   157 WNDKLSLIFFDNYVHRYIHPKARILHLPEQVGLIKARNLAASEAKAENLVFVDAQVEFTNGWLSP 221
            ....|:     .|:.|:  ||.||:...::.|||:.|.|.||.|:.|.|.|:|:..|....||.|
Zfish   186 LKAHLA-----EYMSRF--PKVRIVRTKKREGLIRTRLLGASVARGEVLTFLDSHCEANINWLPP 243

  Fly   222 LLDTIAEQSYTLATPILDNLDEQTLAY--QRSIERRGMYDWSLTRREVPLSRARRSHLPW-PYEV 283
            |||.||:...|:..|::|.:|.....|  |.....||.:||.:..:.:|:....:...|. ||:.
Zfish   244 LLDQIAQNPKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQGPDPSDPYQS 308

  Fly   284 AAVRTSVFAIPAVWFQDISNFDNNLRGFGAAELELSFKVWCTGGRIVQVPCSRVGHLQPKDEDYL 348
            ..:...:||:...||.::..:|..|..:|..:.|:|||||..||.:..||||||||:..|...|
Zfish   309 PVMAGGLFAVNRQWFWELGGYDTGLEIWGGEQFEISFKVWMCGGSMYDVPCSRVGHIYRKYVPY- 372

  Fly   349 KRYGDLHKM--GEQKSRNLKRIIEVWTGDLKSAIYKYQPHLLNISEGDLNEPRKLYKQNECQSFK 411
                   |:  |...:|||||:.|.|..:....||:.:|...::|.|||...::|.|..:|:.||
Zfish   373 -------KVPSGTSLARNLKRVAETWMDEYTEYIYQRRPEYRHLSTGDLTAQKELRKHLKCKDFK 430

  Fly   412 EFINDITPGL-NHVAALNRTDYASGHVKTLEFPKKCLTINAK----SQNLFLERCSTNNTLQNW- 470
            .::|.:...| .:...:.....|.|.::.   ....|.:::|    ...|.|:.|......:.|
Zfish   431 WYMNTVAWDLPKYYPPVEPLPAAWGEIRN---AASGLCVDSKHGSTGTELRLDNCLKEGAERTWA 492

  Fly   471 -----TLTYVKDLRVAG-----NICAE-VRPNLRLGYSFCHSLGGRQSWHY--DSVSNQLMSNTK 522
                 |..:.:|:|...     ..|.: :..|..:....||.:.|.|.|.|  |.....|:| :.
Zfish   493 HEQIFTFGWREDIRPGDPLHTRKFCFDAISQNSPITLYDCHGMKGNQHWSYRKDKSLYHLVS-SG 556

  Fly   523 CLEFT-DELNIFLAICDAANGKQRWILDNINLSVMQSAN 560
            |::.: ::..||:..||..:..|:||...:|.:|:...|
Zfish   557 CMDCSPNDKRIFMNKCDPKSETQQWIFQKVNATVLDKFN 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7304	NP_996098.1	WcaA	108..>231	CDD:223539	52/122 (43%)
		pp-GalNAc-T	113..417	CDD:133004	113/308 (37%)
		Ricin_B_lectin	433..546	CDD:279046	28/131 (21%)
		RICIN	435..548	CDD:238092	28/131 (21%)
galntl6	NP_001139074.1	pp-GalNAc-T	142..437	CDD:133004	113/309 (37%)
		Glyco_tranf_2_2	142..404	CDD:287123	102/276 (37%)
		Ricin_B_lectin	453..581	CDD:279046	28/131 (21%)
		RICIN	455..583	CDD:238092	28/131 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276134at2759
OrthoFinder	1	1.000	-	-		FOG0001284
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.810