DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7304 and GALNTL6

DIOPT Version :9

Sequence 1:	NP_996098.1	Gene:	CG7304 / 39713	FlyBaseID:	FBgn0036527	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	XP_016863733.1	Gene:	GALNTL6 / 442117	HGNCID:	33844	Length:	609	Species:	Homo sapiens

Alignment Length:	574	Identity:	175/574 - (30%)
Similarity:	269/574 - (46%)	Gaps:	81/574 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLHRDLSSWDGLMGPLSHPGLGENGSASYLSVPSWEIDEYTQGWRYYLYNSWLAERIPLRRSLPD 91
            |..:|...::.:.......|.||:|.    ..|..|.|.....:|...:|.:::..|.|.|||||
Human    72 LRRKDWHDYESIQKEAMRSGKGEHGK----PYPLTEEDHDDSAYRENGFNIFVSNNIALERSLPD 132

  Fly    92 LRDHRCQKLEYDEDSDEMKPASIIMIFRNEQLVVLLRTLHSLVERTPKYLYIELILVNDHSDTDF 156
            :|...|:...|.|   .:...|||:.|.||....||||:||::.|||..|..|:|||:|.|:.:.
Human   133 IRHANCKHKMYLE---RLPNTSIIIPFHNEGWTSLLRTIHSIINRTPGSLIAEIILVDDFSEREH 194

  Fly   157 WNDKLSLIFFDNYVHRYIHPKARILHLPEQVGLIKARNLAASEAKAENLVFVDAQVEFTNGWLSP 221
            ..|||     :.|:.|:  .|.||:...::.|||:.|.|.||.|:.|.|.|:|:..|....||.|
Human   195 LKDKL-----EEYMARF--SKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPP 252

  Fly   222 LLDTIAEQSYTLATPILDNLDEQTLAY--QRSIERRGMYDWSLTRREVP----LSRARRSHLPWP 280
            ||:.||....|:..|::|.:|.....|  |.....||.:||.:..:.:|    |.||..|.   |
Human   253 LLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSD---P 314

  Fly   281 YEVAAVRTSVFAIPAVWFQDISNFDNNLRGFGAAELELSFKVWCTGGRIVQVPCSRVGHLQPKDE 345
            :|...:...:||:...||.::..:|..|..:|..:.|:|||||..||.:..||||||||:..|..
Human   315 FESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYV 379

  Fly   346 DYLKRYGDLHKM--GEQKSRNLKRIIEVWTGDLKSAIYKYQPHLLNISEGDLNEPRKLYKQNECQ 408
            .|        |:  |...:|||||:.|.|..:....||:.:|...::|.||::..::|.||.:|:
Human   380 PY--------KVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCK 436

  Fly   409 SFKEFINDIT-------------PG----LNHVAALNRTDYASGHVKTLEFPKKCLTINAKSQNL 456
            .||.|:..:.             |.    :.:|||....|...|               |....|
Human   437 DFKWFMAAVAWDVPKYYPPVEPPPAAWGEIRNVAANLCVDSKHG---------------ATGTEL 486

  Fly   457 FLERCSTNNTLQNW------TLTYVKDLRV-----AGNICAE-VRPNLRLGYSFCHSLGGRQSWH 509
            .|:.|..:.:.:.|      |..:.:|:|.     ....|.: :..|..:....||.:.|.|.|.
Human   487 RLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISHNSPVTLYDCHGMKGNQLWG 551

  Fly   510 Y--DSVSNQLMSNTKCLEFTD-ELNIFLAICDAANGKQRWILDNINLSVMQSAN 560
            |  |......:||: |::... |..||:|.||..:..|:||.::||::|::..|
Human   552 YRKDRTLFHPVSNS-CMDCNPAEKKIFMARCDPLSETQQWIFEHINMTVLEKFN 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7304	NP_996098.1	WcaA	108..>231	CDD:223539	50/122 (41%)
		pp-GalNAc-T	113..417	CDD:133004	114/311 (37%)
		Ricin_B_lectin	433..546	CDD:279046	28/127 (22%)
		RICIN	435..548	CDD:238092	29/127 (23%)
GALNTL6	XP_016863733.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276134at2759
OrthoFinder	1	1.000	-	-		FOG0001284
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810