DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7304 and GALNT8

DIOPT Version :9

Sequence 1:	NP_996098.1	Gene:	CG7304 / 39713	FlyBaseID:	FBgn0036527	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_059113.1	Gene:	GALNT8 / 26290	HGNCID:	4130	Length:	637	Species:	Homo sapiens

Alignment Length:	503	Identity:	132/503 - (26%)
Similarity:	222/503 - (44%)	Gaps:	120/503 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 WRYYLYNSWLAERIPLRRSLPDLRDHRCQKLEYDEDSDEMKPASIIMIFRNEQLVVLLRTLHSLV 134
            :|.:.||::|:.::||.|::||.||:||.:..|   ..::...|:|:||.||.|.::.|.:.|::
Human   144 FRKFGYNAYLSNQLPLNRTIPDTRDYRCLRKTY---PSQLPSLSVILIFVNEALSIIQRAITSII 205

  Fly   135 ERTPKYLYIELILVNDHSDTDFWNDKLSLIFFDNYVHRY--IHP-KARILHLPEQVGLIKARNLA 196
            .|||..|..|:|||:|.|.    |.:|. :..|..:..|  .:| ..:|:..||:.||.:|||..
Human   206 NRTPSRLLKEIILVDDFSS----NGELK-VHLDEKIKLYNQKYPGLLKIIRHPERKGLAQARNTG 265

  Fly   197 ASEAKAENLVFVDAQVEFTNGWLSPLLDTIAEQSYTLATPILDNLDEQTL---AYQRSIERRGMY 258
            ...|.|:.:..:||.:|...||..|:|..|.|....:.:|:.||:...|.   .|:.:::.   :
Human   266 WEAATADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKLDKYELAVDG---F 327

  Fly   259 DWSLTRREVPLSRARRSHLPW--PYEVAA-VRT-SVFAIPAV---WFQDISNFDNNLRGFGAAEL 316
            :|.|..|...|.:|      |  .::|.| |:: |:..|.|.   :..:|.:.|..:..:|...:
Human   328 NWELWCRYDALPQA------WIDLHDVTAPVKSPSIMGILAANRHFLGEIGSLDGGMLIYGGENV 386

  Fly   317 ELSFKVWCTGGRIVQVPCSRVGHLQPKDEDY-------LKRYGDLHKMGEQKSRNLKRIIEVWTG 374
            |||.:||..||::..:||||:.||:...:.|       ||             ||..|:.|:|..
Human   387 ELSLRVWQCGGKVEILPCSRIAHLERHHKPYALDLTAALK-------------RNALRVAEIWMD 438

  Fly   375 DLKSAIY-KYQPHLLN--ISEGDLNEPRKLYKQNECQSFKEFINDITPGLNHVAALNRTDYASGH 436
            :.|..:| .:...|.|  |..||::....|.::.:|::|..::.::.|.|..:    .|....|.
Human   439 EHKHMVYLAWNIPLQNSGIDFGDVSSRMALREKLKCKTFDWYLKNVYPLLKPL----HTIVGYGR 499

  Fly   437 VKTL-----------------------EFPK------------------------KCLTINAKSQ 454
            :|.|                       ||..                        :|||...|::
Human   500 MKNLLDENVCLDQGPVPGNTPIMYYCHEFSSQNVYYHLTGELYVGQLIAEASASDRCLTDPGKAE 564

  Fly   455 NLFLERCS--TNNTLQ-NWTLTYVKDLRVAGNI-------CAEVRPNL 492
            ...||.||  ..|.|. .|      |.:..|.:       |.|::.:|
Human   565 KPTLEPCSKAAKNRLHIYW------DFKPGGAVINRDTKRCLEMKKDL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7304	NP_996098.1	WcaA	108..>231	CDD:223539	43/125 (34%)
		pp-GalNAc-T	113..417	CDD:133004	94/326 (29%)
		Ricin_B_lectin	433..546	CDD:279046	21/117 (18%)
		RICIN	435..548	CDD:238092	21/115 (18%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		1/3 (33%)
		SMC_N	<48..>161	CDD:330553	6/16 (38%)
		GT1 motif	182..298		42/120 (35%)
		pp-GalNAc-T	184..485	CDD:133004	94/327 (29%)
		Gal/GalNAc transferase motif	358..397		10/38 (26%)
		RICIN	498..624	CDD:238092	21/115 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810