Protein Alignment CG7304 and GALNT2

DIOPT Version :10

• Sequence 1: NP_996098.1
• Gene: CG7304 / 39713
• FlyBaseID: FBgn0036527
• Length: 563
• Species: Drosophila melanogaster
• Sequence 2: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 145/594 - (24%)
• Similarity: 257/594 - (43%)
• Gaps: 98/594 - (16%)

  Fly    11 CFKYIVLPVWIFIVLLLLH------------------RDLSSWDGLMGPLSHPGLGENGSASYLS 57
            ||.::    |:..:...::                  .|.:..|.:.....|...||..:.|..:
Human    10 CFAFL----WVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMET 70

  Fly    58 VPSWEI-------DEYTQG---------WRYYLYNSWLAERIPLRRSLPDLRDHRCQKLEYDEDS 106
            :|..::       :.|..|         :....:|...::::.:.|::||.|..:||:.::..|
Human    71 LPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVD- 134

  Fly   107 DEMKPASIIMIFRNEQLVVLLRTLHSLVERTPKYLYIELILVNDHSDTDFWNDKLSLIFFDNYVH 171
              :...|:::.|.||....||||:.|:::::|.:|..|:|||:|:|:.......|..|
Human   135 --LPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKI------- 190

  Fly   172 RYIHPKARILHLPEQVGLIKARNLAASEAKAENLVFVDAQVEFTNGWLSPLLDTIAEQSYTLATP 236
                .|.|:|....:.||:::|...|..|:|:.|.|:|:..|....||.|||:.:||....:.:|
Human   191 ----EKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSP 251

  Fly   237 ILDNLDEQTLAY-QRSIERRGMYDWSLTRR---EVPLSRARRSHLPWPYEVAAVRT-----SVFA 292
            |:|.::.....| ..|.:.:|.:||:|..:   ..|..|..|...|    ||.::|     .:|.
Human   252 IIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNP----VAPIKTPMIAGGLFV 312

  Fly   293 IPAVWFQDISNFDNNLRGFGAAELELSFKVWCTGGRIVQVPCSRVGHLQPKDEDYLKRYGDLHKM 357
            :...:|:::..:|..:..:|...||:||:||..||.:..:|||||||:..|...|....|.
Human   313 MDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGS---- 373

  Fly   358 GEQKSRNLKRIIEVWTGDLKSAIYKYQPHLLNISEGDLNEPRKLYKQNECQSFKEFINDITPGLN 422
            |...:||.:|..|||..:.|:..|...|...|:..|::....:|.|:..|:.||.::.::.|.|.
Human   374 GTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELR 438

  Fly   423 HVAALNRTDYASGHVKTLEFPKKCL-TINAKSQNLF-LERCSTNNTLQNWTLTYVKDLRVAGNIC 485
               ..:..|.|.|   .|:....|| |:...:..:. :..|......|.|.||..|.::.. ::|
Human   439 ---VPDHQDIAFG---ALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHM-DLC 496

  Fly   486 AEV---RPNLRLGYSFCHSLGGRQSWHYDSVSNQLMSNTK--------CLEFTDELN--IFLAIC 537
            ..|   .|...:....|.....||.|      .|:..|:|        ||:.....:  :.:.:|
Human   497 LTVVDRAPGSLIKLQGCRENDSRQKW------EQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVC 555

  Fly   538 DAANGKQRW 546
            ..|. .|:|
Human   556 GPAL-SQQW 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7304	NP_996098.1	pp-GalNAc-T	113..417	CDD:133004	94/312 (30%)
		beta-trefoil_Ricin_Pgant8-like	432..549	CDD:467339	28/130 (22%)
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		5/20 (25%)
		Catalytic subdomain A	135..240		37/115 (32%)
		pp-GalNAc-T	139..434	CDD:133004	94/313 (30%)
		Catalytic subdomain B	300..362		20/61 (33%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	28/129 (22%)