DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7304 and POC1B-GALNT4

DIOPT Version :9

Sequence 1:	NP_996098.1	Gene:	CG7304 / 39713	FlyBaseID:	FBgn0036527	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001186710.1	Gene:	POC1B-GALNT4 / 100528030	HGNCID:	42957	Length:	575	Species:	Homo sapiens

Alignment Length:	531	Identity:	154/531 - (29%)
Similarity:	242/531 - (45%)	Gaps:	49/531 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PLSHPGLGENGSASYLSVPSWEIDEYTQGWRYYLYNSWLAERIPLRRSLPDLRDHRC--QKLEYD 103
            |.....|||.|.||.|.:...|:.:..:....|..|.:|::||.|.|.:.|.|.:.|  ||..|
Human    65 PADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLSDRISLHRHIEDKRMYECKSQKFNY- 128

  Fly   104 EDSDEMKPASIIMIFRNEQLVVLLRTLHSLVERTPKYLYIELILVNDHSDTDFWNDKLSLIFFDN 168
               ..:...|:|:.|.||....||||:||::|.:|..|..|:|||:|.||..:...:|     :.
Human   129 ---RTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRVYLKTQL-----ET 185

  Fly   169 YVHRYIHPKARILHLPEQVGLIKARNLAASEAKAENLVFVDAQVEFTNGWLSPLLDTIAEQSYTL 233
            |:...  .:.|::...::.||::||.:.|:.|..:.|.|:|...|..:|||.|||:.|......:
Human   186 YISNL--DRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETAV 248

  Fly   234 ATPILDNLDEQTLAYQRSIERR--GMYDWSLTRR--EVP-LSRARRSHLPWPYEVAAVRTSVFAI 293
            ..|::|.:|..|..:...|...  |.:||.||.:  .|| ..|.||.....|.....:...:||:
Human   249 VCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDPIRSPTMAGGLFAV 313

  Fly   294 PAVWFQDISNFDNNLRGFGAAELELSFKVWCTGGRIVQVPCSRVGHLQPKDEDYLKRYGDLHKMG 358
            ...:||.:..:|..:..:|...|||||:||..||::...|||.|||:.||...|.:
Human   314 SKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYAR--------- 369

  Fly   359 EQKSRNLKRIIEVWTGDLKSAIYKYQPHLLNISEGDLNEPRKLYKQNECQSFKEFINDITPGLNH 423
            ....:|..|..|||..:.|...|...|.....:.||::|.:.|.::..|:||..::.::.|.| |
Human   370 PNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDISERKLLRERLRCKSFDWYLKNVFPNL-H 433

  Fly   424 VAALNRTDYASGHVKTLEFPKKCLTINAKSQ-----NLFLERCSTNNTLQNWTLTYVKDLRV--A 481
            |.. :|..: .|.:::.....:||..|:...     ||.|..|......|.:..|..|::|.  .
Human   434 VPE-DRPGW-HGAIRSRGISSECLDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSV 496

  Fly   482 GNICAEVRPNLR--LGYSFCHSLG----GRQSWHYDSVSNQLMSNT-KCLEF--TDE--LNIFLA 535
            ..:|||| |..:  :|...|...|    ....||:.........:: .||..  |.|  .::.:.
Human   497 TELCAEV-PEQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTPEGRPDVQMR 560

  Fly   536 ICDAANGKQRW 546
            .|||.:..|.|
Human   561 TCDALDKNQIW 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7304	NP_996098.1	WcaA	108..>231	CDD:223539	41/122 (34%)
		pp-GalNAc-T	113..417	CDD:133004	96/308 (31%)
		Ricin_B_lectin	433..546	CDD:279046	30/130 (23%)
		RICIN	435..548	CDD:238092	31/130 (24%)
POC1B-GALNT4	NP_001186710.1	WcaA	131..427	CDD:223539	96/311 (31%)
		pp-GalNAc-T	135..429	CDD:133004	96/309 (31%)
		RICIN	443..573	CDD:238092	31/130 (24%)
		Ricin_B_lectin	443..571	CDD:279046	30/128 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810