Protein Alignment Phs and ZNF616

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_848618.2
• Gene: ZNF616 / 90317
• HGNCID: 28062
• Length: 781
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 138/469 - (29%)
• Similarity: 205/469 - (43%)
• Gaps: 93/469 - (19%)

  Fly   442 LENAETNSKDNTESVALKETIHDKQLTIDEAGKAGTQKDDNSNQKQLDKSEAN--AGKSKMVDQV 504
            ||..::...:|.....:::.:||.:.         ..||..:|.|::.....|  .||.   ||
Human    74 LERHQSYDIENLYFREIQKHLHDLEF---------QWKDGETNDKEVPVPHENNLTGKR---DQ- 125

  Fly   505 HQQMPVESAKDHQQMTEEPTNSTKRKRGRKERKSPTPVLIPLGDKEIKEEPELPERRMRKSRQHV 569
            |.|..||:.....|:|   :|...|             |..|  ::::.|..|
Human   126 HSQGDVENNHIENQLT---SNFESR-------------LAEL--QKVQTEGRL------------ 160

  Fly   570 DYVVEIKDEEEDDDEVEEAEVDDDSSATISPH-NSST---DESFTSIKRESS---EESQH----- 622
             |            |..|.|...::...:||| ...|   :|...:.|..||   .:..|
Human   161 -Y------------ECNETEKTGNNGCLVSPHIREKTYVCNECGKAFKASSSLINHQRIHTTEKP 212

  Fly   623 ---NGIGG-------------IHT------CNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQCGRA 665
               |..|.             :||      |:.|||.|::.|....|.|.|||:|||:|.:||::
Human   213 YKCNECGKAFHRASLLTVHKVVHTRGKSYQCDVCGKIFRKNSYFVRHQRSHTGQKPYICNECGKS 277

  Fly   666 FRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSDLSI 730
            |.....|..||..|..||.|||::|....:.:..|.||...|..:|.:||::|.|.|.|||:|::
Human   278 FSKSSHLAVHQRIHTGEKPYKCNLCGKSFSQRVHLRLHQTVHTGERPFKCNECGKTFKRSSNLTV 342

  Fly   731 HVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVHMRRHTGEK 795
            |..||.|:|||.||:||||||.|.|||.|||.|.|:|..:|..|.|.|:::..:.||.|.||.||
Human   343 HQVIHAGKKPYKCDVCGKAFRHRSNLVCHRRIHSGEKQYKCNECGKVFSKRSSLAVHRRIHTVEK 407

  Fly   796 PYNCDACQRGYSSRVNLLRHQEREHGIEE-QVPGSGQADKKHTKTATENEQENEPKAKAAPRRPR 859
            |..|:.|.:.:|.|.:|..||....|.:. :....|:...||:..|.........||.......:
Human   408 PCKCNECGKVFSKRSSLAVHQRIHTGQKTYKCNKCGKVYSKHSHLAVHWRIHTGEKAYKCNECGK 472

  Fly   860 REKLQQKIAAQEKL 873
            ...:..::||.:::
Human   473 VFSIHSRLAAHQRI 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	84/226 (37%)
		C2H2 Zn finger	631..651	CDD:275368	8/19 (42%)
		C2H2 Zn finger	715..735	CDD:275368	9/19 (47%)
		C2H2 Zn finger	743..763	CDD:275368	15/19 (79%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		zf-H2C2_2	783..808	CDD:463886	10/24 (42%)
		C2H2 Zn finger	799..816	CDD:275370	5/16 (31%)
ZNF616	NP_848618.2	KRAB	7..47	CDD:460171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	105..129		8/27 (30%)
		SUF4-like	187..>231	CDD:411020	7/43 (16%)
		C2H2 Zn finger	187..208	CDD:411020	4/20 (20%)
		C2H2 Zn finger	187..207	CDD:275368	4/19 (21%)
		C2H2 Zn finger	243..263	CDD:275368	8/19 (42%)
		COG5048	266..707	CDD:227381	84/221 (38%)
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..347	CDD:275368	9/19 (47%)
		C2H2 Zn finger	355..375	CDD:275368	15/19 (79%)
		C2H2 Zn finger	383..403	CDD:275368	7/19 (37%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		C2H2 Zn finger	439..459	CDD:275368	4/19 (21%)
		C2H2 Zn finger	467..487	CDD:275368	2/20 (10%)
		C2H2 Zn finger	495..515	CDD:275368
		C2H2 Zn finger	523..543	CDD:275368
		C2H2 Zn finger	551..571	CDD:275368
		C2H2 Zn finger	579..599	CDD:275368
		C2H2 Zn finger	607..627	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
		C2H2 Zn finger	663..683	CDD:275368
		C2H2 Zn finger	691..711	CDD:275368
		zf-H2C2_2	703..726	CDD:463886
		C2H2 Zn finger	719..739	CDD:275368
		zf-H2C2_2	731..756	CDD:463886
		C2H2 Zn finger	747..767	CDD:275368