Protein Alignment Phs and ZNF229

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_055333.3
• Gene: ZNF229 / 7772
• HGNCID: 13022
• Length: 825
• Species: Homo sapiens
• Alignment Length: 247
• Identity: 100/247 - (40%)
• Similarity: 124/247 - (50%)
• Gaps: 37/247 - (14%)

  Fly   621 QHNGIGGIHTCNFCGKTF------------------------KRFSRMQD---HLRLHTGEKPYV 658
            ||     ::.||.|||:|                        |.|.|..|   |.|:|||||||.
Human   514 QH-----LYKCNVCGKSFSYSSGLLMHQRLHTGEKPYKCECGKSFGRSSDLHIHQRVHTGEKPYK 573

  Fly   659 CGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCNKGFV 723
            |.:||:.||....|..||..|..|:.|.||:|........||.:|.|.|..::.|||.:|.|||.
Human   574 CSECGKGFRRNSDLHSHQRVHTGERPYVCDVCGKGFIYSSDLLIHQRVHTGEKPYKCAECGKGFS 638

  Fly   724 RSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVHM 788
            .||.|.||.|:|||||||.|..|||.||...:|..|:|.|.|.||..|:.|.|.|:...::|.|.
Human   639 YSSGLLIHQRVHTGEKPYRCQECGKGFRCTSSLHKHQRVHTGKKPYTCDQCGKGFSYGSNLRTHQ 703

  Fly   789 RRHTGEKPYNCDACQRGYSSRVNLLRHQEREHGIEE----QVPGSGQADKKH 836
            |.|||||||.|..|.:|:.....||.| :|.|..|:    .|.|.|.:...|
Human   704 RLHTGEKPYTCCECGKGFRYGSGLLSH-KRVHTGEKPYRCHVCGKGYSQSSH 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	78/192 (41%)
		C2H2 Zn finger	631..651	CDD:275368	12/46 (26%)
		C2H2 Zn finger	715..735	CDD:275368	11/19 (58%)
		C2H2 Zn finger	743..763	CDD:275368	9/19 (47%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		zf-H2C2_2	783..808	CDD:463886	13/24 (54%)
		C2H2 Zn finger	799..816	CDD:275370	5/16 (31%)
ZNF229	NP_055333.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		KRAB	33..74	CDD:460171
		C2H2 Zn finger	351..371	CDD:275368
		COG5048	375..787	CDD:227381	100/247 (40%)
		C2H2 Zn finger	379..399	CDD:275368
		C2H2 Zn finger	407..427	CDD:275368
		C2H2 Zn finger	435..455	CDD:275368
		C2H2 Zn finger	463..483	CDD:275368
		C2H2 Zn finger	491..511	CDD:275368
		C2H2 Zn finger	519..539	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..566	CDD:275368	6/18 (33%)
		C2H2 Zn finger	574..594	CDD:275368	8/19 (42%)
		C2H2 Zn finger	602..622	CDD:275368	7/19 (37%)
		C2H2 Zn finger	630..650	CDD:275368	11/19 (58%)
		C2H2 Zn finger	658..678	CDD:275368	9/19 (47%)
		C2H2 Zn finger	686..706	CDD:275368	7/19 (37%)
		C2H2 Zn finger	714..734	CDD:275368	7/20 (35%)
		C2H2 Zn finger	742..762	CDD:275368	4/13 (31%)
		C2H2 Zn finger	770..790	CDD:275368
		C2H2 Zn finger	798..818	CDD:275368