Protein Alignment Phs and ZNF132

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_003424.3
• Gene: ZNF132 / 7691
• HGNCID: 12916
• Length: 706
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 158/619 - (25%)
• Similarity: 224/619 - (36%)
• Gaps: 207/619 - (33%)

  Fly   407 GATQSNNV-VKVQQ----NAKGSKK---------------------DGTQSAQKSET-------- 437
            ||....|| |:|.|    ||..|.|                     .||||.:|..|
Human    87 GAHPKQNVSVEVLQVRIPNADPSTKKANSCDMCGPFLKDILHLAEHQGTQSEEKPYTCGACGRDF 151

  Fly   438 --NPKHLENAETNS--------KDNTESVALKETIH--DKQLTIDEAGKAGTQKDDNSNQKQLDK 490
              |....::.:.:|        ||. :::.....:|  :...|..|.||......|....:.:|.
Human   152 WLNANLHQHQKEHSGGKPFRWYKDR-DALMKSSKVHLSENPFTCREGGKVILGSCDLLQLQAVDS 215

  Fly   491 SEANAGKSKMVDQVHQQMPVESAKDHQQMTEEPTNSTKRKR------GRKERKSPT--------- 540
            .:                     |.:..:.:.|...|.:|.      |:...||.|
Human   216 GQ---------------------KPYSNLGQLPEVCTTQKLFECSNCGKAFLKSSTLPNHLRTHS 259

  Fly   541 ---PVLIPLGDKEIKEEPELPERRMR-------------------KSRQHVDYVVEIKDEE---- 579
               |...|.|...::|:..|..::..                   |.|:|..:..|:|..|
Human   260 EEIPFTCPTGGNFLEEKSILGNKKFHTGEIPHVCKECGKAFSHSSKLRKHQKFHTEVKYYECIAC 324

  Fly   580 -------------------EDDDEVEEAEVDDDSSATISPHNS--STDESFTSIK--RESSEESQ 621
                               |...|.:|......:.:.:..|..  :.:..|..:|  |..|:.|.
Human   325 GKTFNHKLTFVHHQRIHSGERPYECDECGKAFSNRSHLIRHEKVHTGERPFECLKCGRAFSQSSN 389

  Fly   622 HNGIGGIHT------CNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQCGRAFRLKMRLVEHQ---- 676
            ......:||      |:.|||:|.|.|.:..|.|:||||:||.|.:|||||.....|.:||
Human   390 FLRHQKVHTQVRPYECSQCGKSFSRSSALIQHWRVHTGERPYECSECGRAFNNNSNLAQHQKVHT 454

  Fly   677 --------------------LRHR----AEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDK 717
                                |||:    .|:.::|..|....:....|..|.:.|...|.|:|.:
Human   455 GERPFECSECGRDFSQSSHLLRHQKVHTGERPFECCDCGKAFSNSSTLIQHQKVHTGQRPYECSE 519

  Fly   718 CNKGFVRSSDLSIHVRIHTGEKPYSCDLCGKAF--------------RAR------------QN- 755
            |.|.|.|||.|..|.|||||||||.|..|||||              :.|            ||
Human   520 CRKSFSRSSSLIQHWRIHTGEKPYECSECGKAFAHSSTLIEHWRVHTKERPYECNECGKFFSQNS 584

  Fly   756 -LVVHRRTHLGDKPIQCELCDKRFARKIDMRVHMRRHTGEKPYNCDACQRGYSSRVNLLRHQERE 819
             |:.|::.|.|:||.:|..|.|.|:||..:..|.|.||||:||.|..|.|.:||..:|:||| |.
Human   585 ILIKHQKVHTGEKPYKCSECGKFFSRKSSLICHWRVHTGERPYECSECGRAFSSNSHLVRHQ-RV 648

  Fly   820 HGIEE--QVPGSGQA----------DKKHTKTAT 841
            |..|.  :....|:|          .|.||:..|
Human   649 HTQERPYECIQCGKAFSERSTLVRHQKVHTRERT 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	82/258 (32%)
		C2H2 Zn finger	631..651	CDD:275368	9/19 (47%)
		C2H2 Zn finger	715..735	CDD:275368	10/19 (53%)
		C2H2 Zn finger	743..763	CDD:275368	11/47 (23%)
		C2H2 Zn finger	771..791	CDD:275368	8/19 (42%)
		zf-H2C2_2	783..808	CDD:463886	11/24 (46%)
		C2H2 Zn finger	799..816	CDD:275370	7/16 (44%)
ZNF132	NP_003424.3	KRAB	37..78	CDD:460171
		COG5048	105..528	CDD:227381	91/444 (20%)
		C2H2 Zn finger	116..136	CDD:275368	1/19 (5%)
		C2H2 Zn finger	144..164	CDD:275368	1/19 (5%)
		C2H2 Zn finger	238..285	CDD:275368	9/46 (20%)
		C2H2 Zn finger	293..313	CDD:275368	3/19 (16%)
		C2H2 Zn finger	321..341	CDD:275368	0/19 (0%)
		C2H2 Zn finger	349..369	CDD:275368	2/19 (11%)
		C2H2 Zn finger	377..397	CDD:275368	4/19 (21%)
		COG5048	383..>706	CDD:227381	104/301 (35%)
		C2H2 Zn finger	405..425	CDD:275368	9/19 (47%)
		C2H2 Zn finger	433..453	CDD:275368	9/19 (47%)
		C2H2 Zn finger	461..481	CDD:275368	3/19 (16%)
		C2H2 Zn finger	489..509	CDD:275368	4/19 (21%)
		C2H2 Zn finger	517..537	CDD:275368	10/19 (53%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	573..593	CDD:275368	4/19 (21%)
		C2H2 Zn finger	601..621	CDD:275368	8/19 (42%)
		C2H2 Zn finger	629..649	CDD:275368	10/20 (50%)
		C2H2 Zn finger	657..677	CDD:275368	3/19 (16%)
		C2H2 Zn finger	685..705	CDD:275368