DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phs and ZFX

DIOPT Version :10

Sequence 1:NP_648789.3 Gene:Phs / 39697 FlyBaseID:FBgn0036522 Length:971 Species:Drosophila melanogaster
Sequence 2:NP_001317256.1 Gene:ZFX / 7543 HGNCID:12869 Length:844 Species:Homo sapiens


Alignment Length:906 Identity:186/906 - (20%)
Similarity:319/906 - (35%) Gaps:235/906 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 NEEQLEETQKPSN----NKRKARGRPKRKI-----STSSQASSASIASSATLVAA---------- 145
            :|:.||..|:|::    ..|.:...|....     ||::.||.|.:..||:.|..          
Human     2 DEDGLELQQEPNSFFDATDRVSFCHPGWSTVAPSGSTATSASQAQVICSASRVTGATGADGTHMD 66

  Fly   146 --QVLADQKSRRFIYSCTS---CTHHY----DDNLILSRHFQLEHVEKSKRKRGKTKAAAEEPMV 201
              |::.:.:...|:.....   ..|::    .|::::....:...:|..:......:|...|.::
Human    67 GDQIVVEVQETVFVSDVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVI 131

  Fly   202 TPPLIIDP--LEMGQLKPC--------AQLLVQGESVLQLCLACNSQFVDVVRFQEHLSQ-QHGY 255
            .|..::|.  .|...|..|        :.:.....|:.:..|..:|..|..|....|:.. :|..
Human   132 IPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTGDSIHVSDVGHVGHVGHVEHVV 196

  Fly   256 FQLLVPKEEPTDLPPHAMVTIPGALALNKANAQLQLPIPAPETPPPEQDGKEAPPSNASNDK--- 317
            ...:|..|..|| |....|.....|.   |:...:..|.|...|..:||          :||   
Human   197 HDSVVEAEIVTD-PLTTDVVSEEVLV---ADCASEAVIDANGIPVDQQD----------DDKGNC 247

  Fly   318 EDLTMINDMVAVIAAERVKKTSSSKVNKMIIKLPMPKKRGRKRTKPESLRDEQDNAEKTDKKKKL 382
            ||..||    ::..|.:::...||.:.                         .|...:.|.    
Human   248 EDYLMI----SLDDAGKIEHDGSSGMT-------------------------MDTESEIDP---- 279

  Fly   383 NKEEGQQP-VLEPLQAKKTSNQAENGAT---------QSNNVVKVQQNAK---GSKKDGTQSAQK 434
            .|.:|..| |::....|....:.:.|.|         ..:.|..:.||:.   ..:|....:...
Human   280 CKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVND 344

  Fly   435 SETNPKHLENAETN---------SKDNTESVALKETIHDKQLTIDE---------AGKAGTQKDD 481
            |:...:.|..||..         .:::..:.|....:|::|:..:|         |...|...|.
Human   345 SQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDG 409

  Fly   482 NSNQKQLDKSEANAGKSKMVDQVHQQMPVESAKDHQQMTEEPTNSTKRKRGRKERKSPTPVLI-- 544
            ..|:.....:..:..:|..:.::.:|.|                  |::|....|:..|.::|  
Human   410 IENRNGTASALLHIDESAGLGRLAKQKP------------------KKRRRPDSRQYQTAIIIGP 456

  Fly   545 ---PLG-------DKEIKEEPELPERRMRKSRQHV----------DYVVEIK-------DEEEDD 582
               ||.       .|:.|....| :|.|:...:|:          ||....|       :..:..
Human   457 DGHPLTVYPCMICGKKFKSRGFL-KRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHLESHKLT 520

  Fly   583 DEVEEA-EVDDDSSATISPHNSSTDESFT--SIKRESSEESQH----------------NGIGGI 628
            .:.|:| |.|:     ...|.|.....||  .:.:|......|                ..:..:
Human   521 SKAEKAIECDE-----CGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAV 580

  Fly   629 HTCNF------CGKTFKRFSRMQDHLRLHTGEKPYVCGQCGRAFRLKMRLVEH-QLRHRAEKAYK 686
            |:.||      |||.|:..|.::.|:|:|||||||.|..|.........|..| :.:|..|..:|
Human   581 HSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMPFK 645

  Fly   687 CDICSMPLATKQDLSLH-------------------------MRH----HKNDRRYKCDKCNKGF 722
            ||||.:..:..:::..|                         .||    |..|..:|||.|:|||
Human   646 CDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGF 710

  Fly   723 VRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRR---THLGDKPIQCELCDKRFARKIDM 784
            .|.|:|..||..|.|:|.:.|..|.  |:.....|:.|.   .|..|.|.:|:.|.|.|.::.::
Human   711 HRPSELKKHVAAHKGKKMHQCRHCD--FKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQSEL 773

  Fly   785 RVHMRRHTGEKPYNCDACQRGYSSRVNLLRHQEREHGIEEQVPGSGQADKKHTKTATENEQ 845
            :.||:.|:|.|.|.|:.|:...:......||....|  .:..|...:..||..:..:|..|
Human   774 KKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIH--TKDYPHRCEYCKKGFRRPSEKNQ 832

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhsNP_648789.3 COG5048 <594..787 CDD:227381 66/249 (27%)
C2H2 Zn finger 631..651 CDD:275368 9/25 (36%)
C2H2 Zn finger 715..735 CDD:275368 11/19 (58%)
C2H2 Zn finger 743..763 CDD:275368 5/22 (23%)
C2H2 Zn finger 771..791 CDD:275368 6/19 (32%)
zf-H2C2_2 783..808 CDD:463886 8/24 (33%)
C2H2 Zn finger 799..816 CDD:275370 3/16 (19%)
ZFXNP_001317256.1 Zfx_Zfy_act 109..449 CDD:461400 68/404 (17%)
ROS_MUCR <416..>496 CDD:473244 16/98 (16%)
C2H2 Zn finger 466..486 CDD:275368 5/20 (25%)
C2H2 Zn finger 497..521 CDD:275368 3/23 (13%)
C2H2 Zn finger 529..549 CDD:275368 5/24 (21%)
COG5048 582..>719 CDD:227381 42/136 (31%)
C2H2 Zn finger 589..609 CDD:275368 7/19 (37%)
C2H2 Zn finger 617..636 CDD:275368 4/18 (22%)
C2H2 Zn finger 674..695 CDD:275368 2/20 (10%)
C2H2 Zn finger 703..723 CDD:275368 11/19 (58%)
zf-C2H2 758..780 CDD:395048 6/21 (29%)
C2H2 Zn finger 760..780 CDD:275368 6/19 (32%)
zf-H2C2_2 772..796 CDD:463886 8/23 (35%)
C2H2 Zn finger 788..809 CDD:275368 4/20 (20%)
C2H2 Zn finger 817..837 CDD:275368 4/16 (25%)

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