Protein Alignment Phs and ZFP37

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_001269444.1
• Gene: ZFP37 / 7539
• HGNCID: 12863
• Length: 645
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 181/682 - (26%)
• Similarity: 277/682 - (40%)
• Gaps: 166/682 - (24%)

  Fly   259 LVPKEEPTDLPPHAMVTIPGALALNKANAQLQLPIPAPETPP-------------PEQDGKEAPP 310
            ::.|.|..|....|..|       .:|...|::.:..||...             .:::.|:..|
Human     9 ILTKPETVDRRRSAETT-------KEAGRPLEMAVSEPEASAAVSVTFKHVTMAFTQKEWKQLDP 66

  Fly   311 --SNASNDKEDLTMINDMV--AVIAAERVKKTSSSKVNKMII------KLP---MPKKRGRKRTK 362
              ||..||    .|:.:..  |.:..:..|....||:.|...      |.|   .|.|..|.:.|
Human    67 AQSNLYND----VMLENYCNQASMGCQAPKPDMISKLEKGEAPWLGKGKRPSQGCPSKIARPKQK 127

  Fly   363 PESLRDEQDNAEKTDKKKKLNKEEGQQPVLEPLQAKKTSNQAENGAT-----QSNNVVK------ 416
                  |.|...:.|..:..|.::.|..:|..:..||.:...:||:.     :.||:.|
Human   128 ------ETDGKVQKDDDQLENIQKSQNKLLREVAVKKKTQAKKNGSDCGSLGKKNNLHKKHVPSK 186

  Fly   417 ------------VQQN-----------------AKGSKKDGTQSAQ-----KSETNPKHLENAET 447
                        ::||                 ||..||....|..     |.:|..||.:.:..
Human   187 KRLLKFESCGKILKQNLDLPDHSRNCVKRKSDAAKEHKKSFNHSLSDTRKGKKQTGKKHEKLSSH 251

  Fly   448 NSKDNTESVALK-------ETIHDKQLTIDEAGKAGTQKDDNSNQKQLDKSEA--------NAG- 496
            :|.|.......|       .:.|.||..| :.|:...:....|:..:.:|.:|        ..|
Human   252 SSSDKCNKTGKKHDKLCCHSSSHIKQDKI-QTGEKHEKSPSLSSSTKHEKPQACVKPYECNQCGK 315

  Fly   497 ----KSKMVD--QVHQ-QMPVE--------SAKDH---QQMT---EEPTNSTKRKRGRKERKSPT 540
                |..::|  :||. :.|.|        |.|.|   .|.|   |:|....:..:....:.:.|
Human   316 VLSHKQGLIDHQRVHTGEKPYECNECGIAFSQKSHLVVHQRTHTGEKPYECIQCGKAHGHKHALT 380

  Fly   541 PVL-IPLGDKEIKEEPELPE--RRMRKSRQHVDYVVEIKDEEEDDDEVEEAEVDDDSSATISPHN 602
            ..| |..|:|..    |..|  :..|.|...:.:|.....|:                    |:.
Human   381 DHLRIHTGEKPY----ECAECGKTFRHSSNLIQHVRSHTGEK--------------------PYE 421

  Fly   603 -SSTDESFTSIKRESSEESQH--NGIGGI-HTCNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQCG 663
             ....:||    |.:|..::|  ...|.| :.||.|||.||..|.:..|:|:||||||:.|.:||
Human   422 CKECGKSF----RYNSSLTEHVRTHTGEIPYECNECGKAFKYSSSLTKHMRIHTGEKPFECNECG 482

  Fly   664 RAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSDL 728
            :||..|..|:.||..|..||.|||:.|.........|:.|||.|..:..::|::|.|||.:...|
Human   483 KAFSKKSHLIIHQRTHTKEKPYKCNECGKAFGHSSSLTYHMRTHTGESPFECNQCGKGFKQIEGL 547

  Fly   729 SIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVHMRRHTG 793
            :.|.|:|||||||.|:.|||||..:.:|:||:|||.|:||.:|..|:|.|..|..:.:|.|.|||
Human   548 TQHQRVHTGEKPYECNECGKAFSQKSHLIVHQRTHTGEKPYECNECEKAFNAKSQLVIHQRSHTG 612

  Fly   794 EKPYNCDACQRGYSSRVNLLRH-----QEREH 820
            ||||.|:.|.:.:....:|.:|     :::.|
Human   613 EKPYECNECGKTFKQNASLTKHVKTHSEDKSH 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	80/196 (41%)
		C2H2 Zn finger	631..651	CDD:275368	10/19 (53%)
		C2H2 Zn finger	715..735	CDD:275368	8/19 (42%)
		C2H2 Zn finger	743..763	CDD:275368	10/19 (53%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		zf-H2C2_2	783..808	CDD:463886	11/24 (46%)
		C2H2 Zn finger	799..816	CDD:275370	4/21 (19%)
ZFP37	NP_001269444.1	KRAB	47..106	CDD:214630	12/62 (19%)
		COG5048	288..>633	CDD:227381	120/372 (32%)
		C2H2 Zn finger	310..330	CDD:275368	3/19 (16%)
		C2H2 Zn finger	338..358	CDD:275368	4/19 (21%)
		C2H2 Zn finger	366..386	CDD:275368	2/19 (11%)
		C2H2 Zn finger	394..414	CDD:275368	4/19 (21%)
		C2H2 Zn finger	422..442	CDD:275368	5/23 (22%)
		C2H2 Zn finger	450..470	CDD:275368	10/19 (53%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		C2H2 Zn finger	534..554	CDD:275368	8/19 (42%)
		C2H2 Zn finger	562..582	CDD:275368	10/19 (53%)
		C2H2 Zn finger	590..610	CDD:275368	7/19 (37%)
		C2H2 Zn finger	618..638	CDD:275368	4/19 (21%)