Protein Alignment Phs and Zfp251

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_001007569.1
• Gene: Zfp251 / 71591
• MGIID: 1918841
• Length: 632
• Species: Mus musculus
• Alignment Length: 667
• Identity: 168/667 - (25%)
• Similarity: 234/667 - (35%)
• Gaps: 186/667 - (27%)

  Fly   255 YFQLLVPKEEPTDLPPHAMVTIPGALALNKAN-AQLQLPIPAPE-TPPPEQD---------GKEA 308
            ||.    :.|...|.|.........:..|..| |.|..|.|.|| ....||:         |.|.
Mouse    23 YFS----RAEGQQLSPQERALYRDVMLENYGNVASLGFPGPKPELISQLEQEEELWVLDLLGAEE 83

  Fly   309 PP--SNASNDKE-----DLTMINDMVAVIAAERVKKTS--SSKVNKMIIKLPMPKKRGRKRTKPE 364
            |.  .....|.|     :|:::|..    ..|.||...  |.|..:...:...|    ::....|
Mouse    84 PEVLRRCQTDSEIEAEKELSILNQK----CFEEVKTPEFISPKFPRAYSQASEP----QEACAHE 140

  Fly   365 SLRDEQDNAEKTDKKKKLNKEEGQQPVLEPLQAKKTSNQAENGATQSNNVVKVQQNAKGSK---- 425
            ...|....:..|...|.:.|::. ....|.......::..:.....|.:||.||:|..|.:
Mouse   141 GQGDGSHGSSATQGLKSIAKKDA-AVCREQFPKNAQTSVFDKHLNPSQSVVTVQRNKAGQRIFKC 204

  Fly   426 ---------KDGTQSAQKSETNPKHLE-----NAETNSKDNTESVALKETIH--DKQLTIDEAGK 474
                     .......::|.|..|..|     .|.|:|    .::.|.:.||  :|....:|.||
Mouse   205 DICNKTFKYNSDLSRHRRSHTGEKPYECGPCGRAFTHS----SNLILHQRIHTGNKPFKCEECGK 265

  Fly   475 AGTQKDDNSNQKQLDKSEANAGKSKMVDQVHQQMPVESAKDHQQMTEEPTNSTKRKRGRKERKSP 539
                               ..|.:..: ::||::                     ..|.|
Mouse   266 -------------------TFGLNSYL-RLHQRI---------------------HTGEK----- 284

  Fly   540 TPVLIPLGDKEIKEEPELPERRMRKSRQHVDYVVEIKDEEEDDDEVEEAEVDDDSSATISPHNSS 604
                 |.|.||
Mouse   285 -----PFGCKE------------------------------------------------------ 290

  Fly   605 TDESFTSIKRESSEESQHNGIGGIHT------CNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQCG 663
            ..::|:    .||...||.   .|||      |:.|||.|.:..::..|.|:||||||:.|..||
Mouse   291 CGKAFS----RSSSLIQHR---IIHTGEKPYKCDECGKAFSQSPQLTQHQRIHTGEKPHGCTWCG 348

  Fly   664 RAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSDL 728
            :||.....|::||..|..||.:||..|....:....|.||.|.|..::.|.|.:|.:.|..:|.|
Mouse   349 KAFSRNASLIQHQRIHTGEKPHKCAQCGKAFSQSSSLFLHHRVHTGEKPYVCGECGRAFGFNSHL 413

  Fly   729 SIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVHMRRHTG 793
            :.|||||||||||.|..|||||.....|:.|||.|.|:||.||..|.|.|.:...:.:|.|.|||
Mouse   414 TEHVRIHTGEKPYVCGECGKAFSRSSTLMQHRRVHTGEKPYQCAECGKAFIQSSQLTLHQRVHTG 478

  Fly   794 EKPYNCDACQRGYSSRVNLLRHQEREHGIEEQVPGSGQ---ADKKHTKTATENEQENEPKAKAAP 855
            ||||.|..|.:.:|.|..|.:||....|...|....|.   .|..|......:.:.....||..
Mouse   479 EKPYECGLCGKAFSRRSALTQHQRVHMGENPQEFECGPDFVYDSSHLSAGERHGRAFSHSAKLV- 542

  Fly   856 RRPRREKLQQKIAAQEK 872
                   ||..|.:.||
Mouse   543 -------LQWTIRSDEK 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	76/198 (38%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		C2H2 Zn finger	715..735	CDD:275368	8/19 (42%)
		C2H2 Zn finger	743..763	CDD:275368	10/19 (53%)
		C2H2 Zn finger	771..791	CDD:275368	6/19 (32%)
		zf-H2C2_2	783..808	CDD:463886	11/24 (46%)
		C2H2 Zn finger	799..816	CDD:275370	5/16 (31%)
Zfp251	NP_001007569.1	KRAB	15..75	CDD:214630	15/55 (27%)
		zf-C2H2	202..224	CDD:395048	0/21 (0%)
		C2H2 Zn finger	204..224	CDD:275368	0/19 (0%)
		COG5048	228..>509	CDD:227381	114/396 (29%)
		C2H2 Zn finger	232..252	CDD:275368	4/23 (17%)
		C2H2 Zn finger	260..280	CDD:275368	6/60 (10%)
		C2H2 Zn finger	288..308	CDD:275368	7/80 (9%)
		C2H2 Zn finger	316..336	CDD:275368	7/19 (37%)
		C2H2 Zn finger	344..364	CDD:275368	8/19 (42%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		C2H2 Zn finger	428..448	CDD:275368	10/19 (53%)
		C2H2 Zn finger	456..476	CDD:275368	6/19 (32%)
		C2H2 Zn finger	484..504	CDD:275368	7/19 (37%)
		C2H2 Zn finger	556..576	CDD:275368
		C2H2 Zn finger	584..605	CDD:275368