Protein Alignment Phs and topi

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 787
• Identity: 178/787 - (22%)
• Similarity: 284/787 - (36%)
• Gaps: 207/787 - (26%)

  Fly   232 CLACNSQFVDVVRFQEHLSQQHGYFQLLVPKEEPTDLPPHAMVTIPGALALNKANAQLQLPIPAP 296
            |..|..|| |.|.||.| |.:....::.||::|    .||.:.|:...              |||
  Fly   139 CPTCLVQF-DAVAFQNH-SCEAKPIEVAVPQQE----KPHLVPTVSAP--------------PAP 183

  Fly   297 ETPPPEQDGKEAPPSNASNDKEDLTMINDMVAVIAAERVKKTSSSKVNKMIIKLPMPKKRGRKRT 361
            .:.|                              |:|||.:.:..::.:.|       |...|..
  Fly   184 LSKP------------------------------ASERVIRENQVRLRRYI-------KDEMKYD 211

  Fly   362 KPESLRDEQDNAEK-----TDKKKKLNKEEGQQPVLE----PLQAKKTSNQAENGATQSNNVVKV 417
            ....:...:.||.|     |...:|.....|....:|    .|...:||.|.........:|| |
  Fly   212 LATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVV-V 275

  Fly   418 QQNAKG--------SKKDG-TQSAQKSETNPKHLENAETNSKDNTESVALKETIHDKQLTID-EA 472
            :.|:.|        :.:.| ...::.|......:....:|..|      ..|.:.|.::.|| :.
  Fly   276 KCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRAD------FNELLLDGEMLIDNDP 334

  Fly   473 GKAGTQKDDNSNQKQLDKSEANAGKSKMVDQVHQ------------QMPVESAKDHQQMTEEPTN 525
            ..|.:.::.|..:|::       ..|.::..|.|            ::.|.||....:...|.|.
  Fly   335 AFATSNQNTNPPKKEM-------FSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTA 392

  Fly   526 STKRKRGRKERKSPTPVLIPLGDKEIKEEPELPERRMRKSRQHVDYVVEIKDEEEDDDEVEE--- 587
            ...:....||..      |......|.....:....:..||..|..|.|:|  ..:.|.::|
  Fly   393 CDIQMNTAKEAS------IHFQTDCIFMREAIRSLNVTLSRYFVCNVCELK--FANTDLLQEHRC 449

  Fly   588 ------AEVDDDSSATISP-----------HN---SSTDESFTSIKRESSEESQHNGIGGI--HT 630
                  ..::::....:.|           |:   .|.::.....|||  :|:::.|.|.|  :.
  Fly   450 TSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKRE--KETRNTGAGRIRQYL 512

  Fly   631 CNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQ--CGRAFRLKMRLVEHQLR-HRAEKAYKCDICSM 692
            |:.|||::.:.|.:..|||.|.|.||:||.:  |.|.|.::..|.:|..: |..|:.|.|.:|..
  Fly   513 CDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGK 577

  Fly   693 PLATKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLV 757
            ...|......|...|:.:|||:|::|.|.|.|:..|..|.|||||||||||..|.|.||.|
  Fly   578 RFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQR---- 638

  Fly   758 VHRRTHLGDKPIQCELCDKRFARKIDMRVHMR-RHTGEKPYNCDACQRGYSSRVNLLRHQEREHG 821
                   ||:       ||          |:| ||:     :.||..|        |..|.::..
  Fly   639 -------GDR-------DK----------HIRARHS-----HLDANSR--------LMMQMQKFQ 666

  Fly   822 IEEQVPGSGQADKKHTKTATENEQENEPKAKAAP-------RRPRREKLQQKIA--AQEKL---- 873
            :|   ..:.|..:.|.....:|:..........|       ..|...::|..|.  .||::
  Fly   667 LE---TAAAQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTEPSVAEMQYSITPEQQEEMVCVP 728

  Fly   874 LNDLKRSL---SAMPEIPEESAQVKLDGSGQDIPADAGAGHAQVQVTL-SMQMEPAPNTEDDEEI 934
            ::::..|.   ..|..:|.|.     |||||.|......|.....::: ..|....|..|.....
  Fly   729 IDEVNNSFFMSHYMQAVPMEE-----DGSGQHIIVFEQPGQNMDMMSIYDQQQVGEPMHESGVPK 788

  Fly   935 TPEKENA 941
            .|.:|||
  Fly   789 RPAEENA 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	67/211 (32%)
		C2H2 Zn finger	631..651	CDD:275368	8/19 (42%)
		C2H2 Zn finger	715..735	CDD:275368	8/19 (42%)
		C2H2 Zn finger	743..763	CDD:275368	6/19 (32%)
		C2H2 Zn finger	771..791	CDD:275368	4/20 (20%)
		zf-H2C2_2	783..808	CDD:463886	7/25 (28%)
		C2H2 Zn finger	799..816	CDD:275370	4/16 (25%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275370	3/19 (16%)
		C2H2 Zn finger	431..453	CDD:275368	5/23 (22%)
		COG5048	<450..647	CDD:227381	68/226 (30%)
		C2H2 Zn finger	469..490	CDD:275368	2/20 (10%)
		C2H2 Zn finger	513..564	CDD:275368	19/50 (38%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		C2H2 Zn finger	572..592	CDD:275368	4/19 (21%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:463886	16/24 (67%)
		C2H2 Zn finger	628..646	CDD:275368	11/45 (24%)