Protein Alignment Phs and ZNF805

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_001018857.2
• Gene: ZNF805 / 390980
• HGNCID: 23272
• Length: 627
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 155/605 - (25%)
• Similarity: 256/605 - (42%)
• Gaps: 83/605 - (13%)

  Fly   346 MIIKLPMPKKRGRKRTKPESLRDEQDNAEKTDKKKKLNK-----EEGQQPVLEPLQAKKTSN--- 402
            :::.|..|..|      ||.:...:...|...:|:.|::     ::|:....||...:...:
Human    48 LLVSLGCPVPR------PELIYHLEHGQEPWTRKEDLSQGTCPGDKGKPKSTEPTTCELALSEGI 106

  Fly   403 ----QAENGATQSNNVVKVQQNAKGSKKDGTQ-----SAQK----SETNPKH--LENAET-NSKD 451
                |...||:..:.:.:.:.....|:..|.:     .:||    .:.:|||  |..|:: .|:.
Human   107 SFWGQLTQGASGDSQLGQPKDQDGFSEMQGERLRPGLDSQKEKLPGKMSPKHDGLGTADSVCSRI 171

  Fly   452 NTESVALKETIHDKQLTIDEAGKAGTQKDDNSNQKQLDKSEANAGKSKMVDQVHQQMPVESAKDH 516
            ..:.|:|.:.:||    .|..|         |.:..:.:.|.|..|....::|..:..:.:..:.
Human   172 IQDRVSLGDDVHD----CDSHG---------SGKNPVIQEEENIFKCNECEKVFNKKRLLARHER 223

  Fly   517 QQMTEEPTNSTKRKRGRKERKSPTPV---LIPLGDKEIKEEPELPERRMRKSRQHVDYVVEIKDE 578
            .....:|...|  :.|:...||...:   ::..|:|..| ..|..:...|||  |:.....|...
Human   224 IHSGVKPYECT--ECGKTFSKSTYLLQHHMVHTGEKPYK-CMECGKAFNRKS--HLTQHQRIHSG 283

  Fly   579 EEDDDEVEEAEVDDDSSATISPHNSSTDESFTSIKRESSEESQ-----------HNGIGGIHTCN 632
            |: ..:..|........:|...||.|.......:.:|..:..:           |:| ...:.|.
Human   284 EK-PYKCSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHSG-ENPYECF 346

  Fly   633 FCGKTFKRFSRMQDHLRLHTGEKPYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATK 697
            .|||.||..|.:..|.:.|||||||.|.:||:||.....|:.|.:.|..||.::|..|......:
Human   347 ECGKVFKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHR 411

  Fly   698 QDLSLHMRHHKNDRRYKCDKCNKGFVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRT 762
            ..|..|.|.|..::.|.|.:|.|.|...|...:|.|.||||||:.|..|||||..|.:|:.|...
Human   412 SYLKRHQRIHTGEKPYVCSECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRADLIRHFSI 476

  Fly   763 HLGDKPIQCELCDKRFARKIDMRVHMRRHTGEKPYNCDACQRGYSSRVNLLRHQ-----EREHGI 822
            |.|:||.:|..|.|.|.|:..:..|.|.|:|||||.|..|.:.:....||:||.     |:.:..
Human   477 HTGEKPYECMECGKAFNRRSGLTRHQRIHSGEKPYECIECGKTFCWSTNLIRHSIIHTGEKPYEC 541

  Fly   823 EEQVPGSGQADKKHTKTATENEQEN---EPKAKAAPRRPRREKLQQKIAAQEKLLNDLKRSLSAM 884
            .|    .|:|..: :.:.|::::.:   .|.:.....||.... |..:..||.||.  |..|:..
Human   542 SE----CGKAFSR-SSSLTQHQRMHTGRNPISVTDVGRPFTSG-QTSVNIQELLLG--KNFLNVT 598

  Fly   885 PE---IPEESAQVKLDGSGQ 901
            .|   :.||::.:..|.:.|
Human   599 TEENLLQEEASYMASDRTYQ 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	70/203 (34%)
		C2H2 Zn finger	631..651	CDD:275368	8/19 (42%)
		C2H2 Zn finger	715..735	CDD:275368	7/19 (37%)
		C2H2 Zn finger	743..763	CDD:275368	9/19 (47%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		zf-H2C2_2	783..808	CDD:463886	10/24 (42%)
		C2H2 Zn finger	799..816	CDD:275370	5/16 (31%)
ZNF805	NP_001018857.2	KRAB	13..73	CDD:214630	6/30 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..95		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..162		9/48 (19%)
		C2H2 Zn finger	205..225	CDD:275368	1/19 (5%)
		zf-H2C2_2	218..242	CDD:463886	3/25 (12%)
		C2H2 Zn finger	233..253	CDD:275368	4/21 (19%)
		COG5048	257..>580	CDD:227381	102/333 (31%)
		C2H2 Zn finger	261..281	CDD:275368	5/21 (24%)
		C2H2 Zn finger	289..309	CDD:275368	4/19 (21%)
		C2H2 Zn finger	317..337	CDD:275368	1/19 (5%)
		C2H2 Zn finger	345..365	CDD:275368	8/19 (42%)
		C2H2 Zn finger	373..393	CDD:275368	7/19 (37%)
		C2H2 Zn finger	401..421	CDD:275368	5/19 (26%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		C2H2 Zn finger	541..561	CDD:275368	4/24 (17%)