Protein Alignment Phs and ZNF470

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_001001668.3
• Gene: ZNF470 / 388566
• HGNCID: 22220
• Length: 717
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 144/554 - (25%)
• Similarity: 232/554 - (41%)
• Gaps: 98/554 - (17%)

  Fly   361 TKPESLRDEQDNAEKTDKKKKLNKEEGQQPVLEPLQAKKTSNQAENGATQSNNVVKVQQNAKGSK 425
            |..::|.:::|::.|:.....||.....:.:. |::.:..:...:..:.::::|||..:..:|.|
Human   162 THIDTLIEKRDHSNKSGTVFHLNTLSYIKQIF-PMEERIFNFHTDKKSLKTHSVVKKHKQDRGEK 225

  Fly   426 K-----DGTQSAQKSETNPKHLENAETNSK-----------DNTESVALKETIH--DKQLTIDEA 472
            |     |..:...|..|...| :...|..|           ..:..:|..:.||  :|.....|.
Human   226 KLLKCNDCEKIFSKISTLTLH-QRIHTGEKPYECIECGKAFSQSAHLAQHQRIHTGEKPFECTEC 289

  Fly   473 GKAGTQKDD-------NSNQKQLDKSEANAGKSKMV-----DQVHQ-QMPVESAKDHQQMTEEPT 524
            |||.:|...       ::.:|.....:.|...|::.     .:||. :.|.|..:..:..::  .
Human   290 GKAFSQNAHLVQHQRVHTGEKPYQCKQCNKAFSQLAHLAQHQRVHTGEKPYECIECGKAFSD--C 352

  Fly   525 NSTKRKRGRKERKSPTPVLIPLGDKEIKEEPELPERR------------MRKSRQHVDYVVEIKD 577
            :|....|.....|.|.. .|..| |..::...|...|            :...:...|::..|:.
Human   353 SSLAHHRRIHTGKRPYE-CIDCG-KAFRQNASLIRHRRYYHTGEKPFDCIDCGKAFTDHIGLIQH 415

  Fly   578 EEEDDDE------VEEAEVDDDSSATI--------SPHNSSTDESFTSIK--------------- 613
            :.....|      |........||.|:        .|:..:..|...|.:
Human   416 KRTHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICEKAFSHRGSLTLHQRVHTGEKP 480

  Fly   614 ----------RESSEESQHNGIGGIHT------CNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQC 662
                      |:|:..:.|.   .|||      |..|.|||.:.:.:..|.::|||||||.|.:|
Human   481 YECKECGKAFRQSTHLAHHQ---RIHTGEKPYECKECSKTFSQNAHLAQHQKIHTGEKPYECKEC 542

  Fly   663 GRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSD 727
            |:||.....||:||..|..||.|:|..|....:....|..|.|.|...|.|:|.:|.|.|.:.:.
Human   543 GKAFSQIAHLVQHQRVHTGEKPYECIECGKAFSDGSYLVQHQRLHSGKRPYECLECGKAFRQRAS 607

  Fly   728 LSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVHMRRHT 792
            |..|.|.|||||||.|::|||||..|::|.:|:|.|.|:||.:|:.|.|.|::...:.:|.|.||
Human   608 LICHQRCHTGEKPYECNVCGKAFSHRKSLTLHQRIHTGEKPYECKECSKAFSQVAHLTLHKRIHT 672

  Fly   793 GEKPYNCDACQRGYSSRVNLLRHQEREHGIEEQV 826
            ||:||.|..|.:.:...|:|..|| |.|..|..|
Human   673 GERPYECKECGKAFRQSVHLAHHQ-RIHTGESSV 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	78/231 (34%)
		C2H2 Zn finger	631..651	CDD:275368	6/19 (32%)
		C2H2 Zn finger	715..735	CDD:275368	7/19 (37%)
		C2H2 Zn finger	743..763	CDD:275368	10/19 (53%)
		C2H2 Zn finger	771..791	CDD:275368	6/19 (32%)
		zf-H2C2_2	783..808	CDD:463886	10/24 (42%)
		C2H2 Zn finger	799..816	CDD:275370	4/16 (25%)
ZNF470	NP_001001668.3	KRAB	23..83	CDD:214630
		Nuclear localization signal. /evidence=ECO:0000255	216..219		1/2 (50%)
		C2H2 Zn finger	230..250	CDD:275368	4/20 (20%)
		COG5048	254..669	CDD:227381	109/421 (26%)
		C2H2 Zn finger	258..278	CDD:275368	1/19 (5%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	2/19 (11%)
		C2H2 Zn finger	342..362	CDD:275368	2/21 (10%)
		C2H2 Zn finger	370..388	CDD:275368	4/18 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	385..388		0/2 (0%)
		C2H2 Zn finger	399..419	CDD:275368	2/19 (11%)
		C2H2 Zn finger	427..447	CDD:275368	4/19 (21%)
		C2H2 Zn finger	455..475	CDD:275368	2/19 (11%)
		C2H2 Zn finger	483..503	CDD:275368	3/22 (14%)
		C2H2 Zn finger	511..531	CDD:275368	6/19 (32%)
		C2H2 Zn finger	539..559	CDD:275368	9/19 (47%)
		C2H2 Zn finger	567..587	CDD:275368	5/19 (26%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		C2H2 Zn finger	623..643	CDD:275368	10/19 (53%)
		C2H2 Zn finger	651..671	CDD:275368	6/19 (32%)
		zf-H2C2_2	663..688	CDD:463886	10/24 (42%)
		C2H2 Zn finger	679..699	CDD:275368	7/20 (35%)