Protein Alignment Phs and ZNF404

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_001028891.2
• Gene: ZNF404 / 342908
• HGNCID: 19417
• Length: 552
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 129/523 - (24%)
• Similarity: 191/523 - (36%)
• Gaps: 103/523 - (19%)

  Fly   406 NGATQSNNVVKVQQNAKGSKKDGTQSAQKSETNPKHLENAETNSKDNTESVALKETIHDKQLTID 470
            |..|:||.:...::|              .|.|..|.|..:.|...|......:.   |.|.||:
Human    48 NFTTESNKLSSEKRN--------------YEVNAYHQETWKRNKTFNLMRFIFRT---DPQYTIE 95

  Fly   471 ----EAGKAG--------------TQKDDNSNQKQLDKSEANAGKSKMVDQVHQQMPVESAKDHQ 517
                :..|.|              ..|.:|:.:|..:..|...|..|.:..      .|..:||.
Human    96 FGRQQRPKVGCFSQMIFKKHKSLPLHKRNNTREKSYECKEYKKGFRKYLHL------TEHLRDHT 154

  Fly   518 QMTEEPTNSTKRK--------RGRKERKSPTPVLIPLGDKEIKEEPELPE--------------- 559
            .:.....|...:.        |.||......|......:|..:...:|.:
Human   155 GVIPYECNECGKAFVVFQHFIRHRKIHTDLKPYECNGCEKAFRFYSQLIQHQIIHTGMKPYECKQ 219

  Fly   560 -----RRMRKSRQHVDYVVEIKDEEEDDDEVEEAEVDDDSSATISPHNSSTDESFTSIKRESSEE 619
                 ||.....:|....|.:|..|                      .....|:|...:.....:
Human   220 CGKAFRRHSHLTEHQKIHVGLKPFE----------------------CKECGETFRLYRHMCLHQ 262

  Fly   620 SQHNGIGGIHTCNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQCGRAFRLKMRLVEHQLRHRAEKA 684
            ..|:|:.. :.|..|||.|...|.:..|.::|:|||||.|.||.:||.....|||||..|..||.
Human   263 KIHHGVKP-YKCKECGKAFGHRSSLYQHKKIHSGEKPYKCEQCEKAFVRSYLLVEHQRSHTGEKP 326

  Fly   685 YKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSDLSIHVRIHTGEKPYSCDLCGKA 749
            ::|..|.........|..|.|.|.:::.|.|..|.|.|.|.|.|:.|.||||||||:.|..|||.
Human   327 HECMECGKAFGKGSSLLKHKRIHSSEKLYDCKDCGKAFCRGSQLTQHQRIHTGEKPHECKECGKT 391

  Fly   750 FRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVHMRRHTGEKPYNCDACQRGYSSRVNLLR 814
            |:....|:.|:..|...||.:|:.|.|.|:|..|::.|...|.|||||.|..|.:.:.....|:.
Human   392 FKLHSYLIQHQIIHTDLKPYECKQCGKAFSRVGDLKTHQSIHAGEKPYECKECGKTFRLNSQLIY 456

  Fly   815 HQEREHGIE-----------EQVPGSGQADKKHTKTATENEQENEPKAKAAPRRPRREKLQQKIA 868
            ||....|::           ..:.|..|..:.||.......:|.:.....:.|..:.|.:...:.
Human   457 HQTIHTGLKPYVCKECKKAFRSISGLSQHKRIHTGEKPYECKECDKAFNRSDRLTQHETIHTGVK 521

  Fly   869 AQE 871
            .|:
Human   522 PQK 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	69/192 (36%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		C2H2 Zn finger	715..735	CDD:275368	9/19 (47%)
		C2H2 Zn finger	743..763	CDD:275368	7/19 (37%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		zf-H2C2_2	783..808	CDD:463886	10/24 (42%)
		C2H2 Zn finger	799..816	CDD:275370	3/16 (19%)
ZNF404	NP_001028891.2	KRAB	6..>51	CDD:214630	1/2 (50%)
		C2H2 Zn finger	133..153	CDD:275368	4/25 (16%)
		COG5048	158..546	CDD:227381	103/390 (26%)
		C2H2 Zn finger	161..181	CDD:275368	4/19 (21%)
		C2H2 Zn finger	189..209	CDD:275368	2/19 (11%)
		C2H2 Zn finger	217..237	CDD:275368	3/19 (16%)
		C2H2 Zn finger	245..265	CDD:275368	2/19 (11%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..321	CDD:275368	10/19 (53%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		C2H2 Zn finger	469..489	CDD:275368	2/19 (11%)
		C2H2 Zn finger	497..517	CDD:275368	3/19 (16%)
		C2H2 Zn finger	525..545	CDD:275368	129/523 (25%)