DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phs and ZNF454

DIOPT Version :10

Sequence 1:NP_648789.3 Gene:Phs / 39697 FlyBaseID:FBgn0036522 Length:971 Species:Drosophila melanogaster
Sequence 2:NP_872400.2 Gene:ZNF454 / 285676 HGNCID:21200 Length:522 Species:Homo sapiens


Alignment Length:494 Identity:137/494 - (27%)
Similarity:208/494 - (42%) Gaps:77/494 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   350 LPMPKKRGRKRTKPESLRDEQDNAEKTDKKKKLNKEE-------GQQPVLE--PLQAKKTSNQA- 404
            :|..||...|...||...|:....|:...........       ||:..|:  .|....|.:|. 
Human    88 MPASKKSTVKAEIPEEELDQWTIKERFSSSSHWKCASLLEWQCGGQEISLQRVVLTHPNTPSQEC 152

  Fly   405 -ENGATQSNNVVKVQQNAKGSKKDGTQSAQ------KSETNPKHLENAETNSKDNTESVALKETI 462
             |:|:|.|:::...|.......|:..:.::      ||.|..||  ....|.|:..:.:.:||  
Human   153 DESGSTMSSSLHSDQSQGFQPSKNAFECSECGKVFSKSSTLNKH--QKIHNEKNANQKIHIKE-- 213

  Fly   463 HDKQLTIDEAGKAGTQKDDNSNQKQLDKSEANAGKSKMVDQVHQQMPVESAKDHQQMTEEPTNST 527
              |:....|.|||..|.....:.:::...|    |.....:..:...|.|:..:.|         
Human   214 --KRYECRECGKAFHQSTHLIHHQRIHTGE----KPYECKECGKAFSVSSSLTYHQ--------- 263

  Fly   528 KRKRGRKERKSPTPVLIPLGDKEIKEEPELPERRMRKSRQHVDYVVEIKDEEEDDDEVEEAEVDD 592
            |...|.|      |....|..|..       .|.:..:..|..:..|                  
Human   264 KIHTGEK------PFECNLCGKAF-------IRNIHLAHHHRIHTGE------------------ 297

  Fly   593 DSSATISPHNSS-TDESFTSIKRESSEESQHNGIGGIHTCNFCGKTFKRFSRMQDHLRLHTGEKP 656
                  .|...: .:::|......:..::.|:| ...:.||.|||.|.:.:....|.|:||||||
Human   298 ------KPFKCNICEKAFVCRAHLTKHQNIHSG-EKPYKCNECGKAFNQSTSFLQHQRIHTGEKP 355

  Fly   657 YVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCNKG 721
            :.|.:||:|||:...|.|||..|..||.|||:.|..........:.|.:.|..::.|:|..|.|.
Human   356 FECNECGKAFRVNSSLTEHQRIHTGEKPYKCNECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKA 420

  Fly   722 FVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRV 786
            |...|.|:.|.|||||||||:|::|.|||.....|..|:|.|..:||.:|::|:|.|.|...:..
Human   421 FRDQSALAQHQRIHTGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKICEKAFIRSTHLTQ 485

  Fly   787 HMRRHTGEKPYNCDACQRGYSSRVNLLRHQEREHGIEEQ 825
            |.|.|||||||.|:.|.:.::...||::||  .|.|.|:
Human   486 HQRIHTGEKPYKCNKCGKAFNQTANLIQHQ--RHHIGEK 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhsNP_648789.3 COG5048 <594..787 CDD:227381 70/193 (36%)
C2H2 Zn finger 631..651 CDD:275368 8/19 (42%)
C2H2 Zn finger 715..735 CDD:275368 8/19 (42%)
C2H2 Zn finger 743..763 CDD:275368 8/19 (42%)
C2H2 Zn finger 771..791 CDD:275368 7/19 (37%)
zf-H2C2_2 783..808 CDD:463886 11/24 (46%)
C2H2 Zn finger 799..816 CDD:275370 4/16 (25%)
ZNF454NP_872400.2 KRAB 14..73 CDD:214630
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..170 7/22 (32%)
C2H2 Zn finger 180..200 CDD:275368 5/21 (24%)
COG5048 186..522 CDD:227381 116/394 (29%)
C2H2 Zn finger 218..238 CDD:275368 5/19 (26%)
C2H2 Zn finger 246..266 CDD:275368 4/28 (14%)
C2H2 Zn finger 274..294 CDD:275368 4/26 (15%)
C2H2 Zn finger 302..322 CDD:275368 1/19 (5%)
C2H2 Zn finger 330..350 CDD:275368 8/19 (42%)
C2H2 Zn finger 358..378 CDD:275368 10/19 (53%)
C2H2 Zn finger 386..406 CDD:275368 3/19 (16%)
C2H2 Zn finger 414..434 CDD:275368 8/19 (42%)
C2H2 Zn finger 442..462 CDD:275368 8/19 (42%)
C2H2 Zn finger 470..490 CDD:275368 7/19 (37%)
C2H2 Zn finger 498..518 CDD:275368 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

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