Protein Alignment Phs and ZNF875

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: XP_016882161.1
• Gene: ZNF875 / 284459
• HGNCID: 4928
• Length: 704
• Species: Homo sapiens
• Alignment Length: 814
• Identity: 193/814 - (23%)
• Similarity: 273/814 - (33%)
• Gaps: 256/814 - (31%)

  Fly   120 RPKRKISTSSQASSASI-----ASSATLVAAQVLADQKSRRFI----------------YSCTSC 163
            ||...:.||...||.::     ::..|...|..|...|...|:                .|....
Human    35 RPLLFLFTSPDLSSETLPFSRKSTQETRKMATGLLRAKKEAFVAFRDVAVYFTQEEWRLLSPAQR 99

  Fly   164 THHYDDNLILSRHFQLEHVEKSKRK------RGKTKAAAEEPMVTPPLIIDPLEMG---QLKPCA 219
            |.|.:..|....|.....:..||.|      ||:.....|...   ||.:.|.|..   ||.|..
Human   100 TLHREVMLETYNHLVSLEIPSSKPKLIAQLERGEAPWREERKC---PLDLCPAESKPEIQLSPSC 161

  Fly   220 QLLVQGESVLQLCLACNSQFVDVVRFQEHLSQQHGYFQLLVPKEEPTDLPPHAMVTIPGALALNK 284
            .|:...:..|       ||.|    :..||||   .|..|                        .
Human   162 PLIFSSQQAL-------SQHV----WLSHLSQ---LFSSL------------------------W 188

  Fly   285 ANAQLQLPIPAPETPPPEQD-----GKEAPPSNASNDKEDLTMINDMVAVIAAERVKKTSSSKVN 344
            |...|.|....||....:||     ||    :....:.||..::        ..||.|..:||.
Human   189 AGNPLHLGKHYPEDQKQQQDPFCFSGK----AEWIQEGEDSRLL--------FGRVSKNGTSKA- 240

  Fly   345 KMIIKLPMPKKRGRKRTKPE-------SLRDEQDNAEKTDKKKKLNKEEGQQPVLEPLQAKKTSN 402
               :..| |:::...::|.:       |..:.:.:.|:|||            ||..|:   .|.
Human   241 ---LSSP-PEEQQPAQSKEDNTVVDIGSSPERRADLEETDK------------VLHGLE---VSG 286

  Fly   403 QAENGATQSNNVVKVQQNAKG-SKKDGTQSAQKSETNPKHLENAETNSKDNTESVALKE-TIHD- 464
            ..|         :|.::...| .|:....|.||::|........|......:.||.:|. ..|.
Human   287 FGE---------IKYEEFGPGFIKESNLLSLQKTQTGETPYMYTEWGDSFGSMSVLIKNPRTHSG 342

  Fly   465 -KQLTIDEAGKAGTQKDD-------NSNQKQLDKSEANAG---KSKMV--DQVHQQMPVESAKDH 516
             |.....|.|:..|.|.:       :|.:|.....:...|   ||.:.  .:.|..:.....|:.
Human   343 GKPYVCRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRGFTWKSNLFTHQRTHSGLKPYVCKEC 407

  Fly   517 QQMTEEPTNSTKRKRGRKERKSPTPVLIPLGDKEIKEEPELPERRMRKSRQHVDYVVEIKDEEED 581
            .|.....:|....:|.                 ...|:|.:.....|..|||...|..
Human   408 GQSFSLKSNLITHQRA-----------------HTGEKPYVCRECGRGFRQHSHLVRH------- 448

  Fly   582 DDEVEEAEVDDDSSATISPHNSSTDESFTSIKRESSEESQHNGIGGIHTCNFCGKTFKRFSRMQD 646
                                           ||..|.|..       :.|..|.:.|.:.|.:..
Human   449 -------------------------------KRTHSGEKP-------YICRECEQGFSQKSHLIR 475

  Fly   647 HLRLHTGEKPYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDR 711
            |||.|||||||||.:|||.|..|..|..||..|...|.|.|..|....:.|.:|:.|.|.|..::
Human   476 HLRTHTGEKPYVCTECGRHFSWKSNLKTHQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEK 540

  Fly   712 RYKCDKCNKGFVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDK 776
            .:.|.:|.:||.|.|.||.|.|.|:||||:.|..||:.|..:..|:.|:|||.|:||..|..|.:
Human   541 PFVCTECGRGFTRKSTLSTHQRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEKPFMCRECGR 605

  Fly   777 RFARKIDM------------------------------RV------------------------H 787
            ||.:|.::                              |.                        |
Human   606 RFRQKPNLFRHKRAHSGAFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECGQGFSRQSHLIRH 670

  Fly   788 MRRHTGEKPYNCDACQRGYSSRVNLLRHQEREHG 821
            .|.|:|||||.|..|.||:|.:.||:|||....|
Human   671 QRTHSGEKPYICRKCGRGFSRKSNLIRHQRTHSG 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	71/246 (29%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		C2H2 Zn finger	715..735	CDD:275368	10/19 (53%)
		C2H2 Zn finger	743..763	CDD:275368	7/19 (37%)
		C2H2 Zn finger	771..791	CDD:275368	8/73 (11%)
		zf-H2C2_2	783..808	CDD:463886	13/78 (17%)
		C2H2 Zn finger	799..816	CDD:275370	8/16 (50%)
ZNF875	XP_016882161.1	KRAB	77..136	CDD:214630	10/58 (17%)
		C2H2 Zn finger	324..340	CDD:275368	3/15 (20%)
		COG5048	344..703	CDD:227381	111/420 (26%)
		C2H2 Zn finger	348..368	CDD:275368	4/19 (21%)
		C2H2 Zn finger	376..396	CDD:275368	3/19 (16%)
		C2H2 Zn finger	404..424	CDD:275368	4/36 (11%)
		C2H2 Zn finger	432..452	CDD:275368	7/57 (12%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	9/19 (47%)
		C2H2 Zn finger	516..536	CDD:275368	6/19 (32%)
		C2H2 Zn finger	544..564	CDD:275368	10/19 (53%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		C2H2 Zn finger	626..646	CDD:275368	1/19 (5%)
		C2H2 Zn finger	654..674	CDD:275368	2/19 (11%)
		C2H2 Zn finger	682..702	CDD:275368	10/19 (53%)