Protein Alignment Phs and Zfp454

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_766382.2
• Gene: Zfp454 / 237758
• MGIID: 2679253
• Length: 536
• Species: Mus musculus
• Alignment Length: 640
• Identity: 157/640 - (24%)
• Similarity: 248/640 - (38%)
• Gaps: 161/640 - (25%)

  Fly   211 EMGQLKPCAQLLVQG------ESVLQLCLACNSQ---FVDVVRFQEHLSQQHGYFQLLVPKEEPT 266
            |.|||....:.|.|.      .:::.|.....||   |..:...:|.:|::.....:|...:||
Mouse    27 EWGQLSSAQRALYQDVMLENYSNLVSLAGLLGSQPDMFFPLEEVEECVSEEAPEGFVLDAADEP- 90

  Fly   267 DLPP----HAMVTIPGALALNKANAQLQLPIPAPETPPPEQDGKEAPPSNASNDKEDLTMINDMV 327
            .|.|    .|.|.:.|.:.:..:...|:..||..|:  .:...||...:|..|
Mouse    91 HLGPRSACEAQVPVTGEITVAMSKKFLKADIPEKES--DQWIAKERACANLFN------------ 141

  Fly   328 AVIAAERVKKTSSSKVNKMIIKLPMPKKRGRKRTKPESLRDEQDNAEKTDKKKKLNKEEGQQPVL 392
                 .:.::....|:.::::         .::..|..|.:::..||.:
Mouse   142 -----WQCQEGQEVKLQQVVL---------TQQNTPSKLSEQRVRAESS---------------- 176

  Fly   393 EPLQAKKTSNQAENGATQSNNVVKVQQNAKGSKKDGTQSAQKSETNPKHLENAETNSKDNTESV- 456
            .|:|:::  :||...|.:.:...|              :..||.|..||       .|.:||.:
Mouse   177 SPIQSQR--SQASKTAFECSECGK--------------AFSKSSTLKKH-------QKLHTEKLN 218

  Fly   457 -ALKETIHDKQLTIDEAGKAGTQKDDNSNQKQLDKSE-----ANAGKSKMVDQVHQQMPVESAKD 515
             :.|..:.:|:....|.|||..|.....:.:::...|     .:.||:..|.        .|...
Mouse   219 PSQKSPMKEKRYKCRECGKAFHQSTHLIHHQRVHTGEKPYQCKDCGKAFSVS--------SSLSY 275

  Fly   516 HQQMTEEPTNSTKRKRGRKERKSPTPVLIPLGDK--EIKEEPELPERRMRKSRQHVDYVVEIKDE 578
            ||:                         |..|:|  |.....:...|.:..|..|..:..|
Mouse   276 HQK-------------------------IHTGEKPFECNVCGKAFIRNIHLSHHHRMHTGE---- 311

  Fly   579 EEDDDEVEEAEVDDDSSATISPHNSS-TDESFTSIKRESSEESQHNGIGGIHT------CNFCGK 636
                                .|...: .|::|  :.|....:.||     ||:      ||.|||
Mouse   312 --------------------KPFQCNLCDKAF--VCRAHLTKHQH-----IHSGKKPYKCNECGK 349

  Fly   637 TFKRFSRMQDHLRLHTGEKPYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLS 701
            .|.:.:....|.|:||||||:.|.:||:|||:...|.|||..|..||.|:|..|..........:
Mouse   350 AFNQSTSFLQHQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPYQCIECGKAFRDNSSFA 414

  Fly   702 LHMRHHKNDRRYKCDKCNKGFVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGD 766
            .|.:.|..::.|:|..|.|.|...|.|:.|.|.|||||||:|::|.|||.....|..|:|.|..:
Mouse   415 RHRKIHTGEKPYRCGLCEKAFRDQSALAQHQRTHTGEKPYTCNICEKAFSDHSALTQHKRIHTRE 479

  Fly   767 KPIQCELCDKRFARKIDMRVHMRRHTGEKPYNCDACQRGYSSRVNLLRHQEREHG 821
            ||.:|:.|.|.|.|...:..|.|.|||||||.|:.|.:.::...||.:||....|
Mouse   480 KPYKCKTCGKAFIRSTHLIQHQRIHTGEKPYKCNTCGKAFNQTANLAQHQRHHTG 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	72/199 (36%)
		C2H2 Zn finger	631..651	CDD:275368	8/19 (42%)
		C2H2 Zn finger	715..735	CDD:275368	8/19 (42%)
		C2H2 Zn finger	743..763	CDD:275368	8/19 (42%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		zf-H2C2_2	783..808	CDD:463886	11/24 (46%)
		C2H2 Zn finger	799..816	CDD:275370	4/16 (25%)
Zfp454	NP_766382.2	KRAB	14..67	CDD:214630	10/39 (26%)
		C2H2 Zn finger	193..213	CDD:275368	7/40 (18%)
		COG5048	197..532	CDD:227381	118/419 (28%)
		C2H2 Zn finger	232..252	CDD:275368	5/19 (26%)
		C2H2 Zn finger	260..280	CDD:275368	6/52 (12%)
		C2H2 Zn finger	288..308	CDD:275368	3/19 (16%)
		C2H2 Zn finger	316..336	CDD:275368	5/26 (19%)
		C2H2 Zn finger	344..364	CDD:275368	8/19 (42%)
		C2H2 Zn finger	372..392	CDD:275368	10/19 (53%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	428..448	CDD:275368	8/19 (42%)
		C2H2 Zn finger	456..476	CDD:275368	8/19 (42%)
		C2H2 Zn finger	484..504	CDD:275368	7/19 (37%)
		C2H2 Zn finger	512..532	CDD:275368	6/19 (32%)