Protein Alignment Phs and GLIS3

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_001035878.1
• Gene: GLIS3 / 169792
• HGNCID: 28510
• Length: 930
• Species: Homo sapiens
• Alignment Length: 866
• Identity: 158/866 - (18%)
• Similarity: 273/866 - (31%)
• Gaps: 265/866 - (30%)

  Fly   246 QEHLSQQHGYFQLLVPKEEP-TDLPPHAMVTIPGALALNKANAQLQLPIPAPETPPPEQDGKEAP 309
            |.::::...:...|.|:.:. |:..|...||..|.::.:......|....:|..|.|.:......
Human    71 QNNVAESRIHLPALSPRRQMLTNGKPRFQVTQAGGMSGSHTLKPKQQEFGSPFPPNPGKGALGFG 135

  Fly   310 PSNASNDKEDLTMINDMVAVIAAERVKK------------TSSSKVNKMI------IKLPMPKKR 356
            |...|..|..   .|::|...:...|::            |:.::::..:      ..|.:|...
Human   136 PQCKSIGKGS---CNNLVVTSSPMMVQRLGLISPPASQVSTACNQISPSLQRAMNAANLNIPPSD 197

  Fly   357 GRKRTKPESLRDEQDNAEKTDKKKKLNKEEGQ-QPVLEPLQAKKTSNQAE--------NGATQSN 412
            .|.....|||.....:..::.....:.:|..| ...|..|....:.|..:        .|.:.|:
Human   198 TRSLISRESLASTTLSLTESQSASSMKQEWSQGYRALPSLSNHGSQNGLDLGDLLSLPPGTSMSS 262

  Fly   413 NVVKVQQNAKGSKKDGTQSAQKSETNPKHLENAETNSKDNTESVALKETIHDKQLTIDEAGKAGT 477
            |.|   .|:..|...||:|:.....:|:|......:::....:::| ..:.|           |.
Human   263 NSV---SNSLPSYLFGTESSHSPYPSPRHSSTRSHSARSKKRALSL-SPLSD-----------GI 312

  Fly   478 QKDDN--------SNQKQLDKSEANAGKSKMVDQVH------------QQMPV------------ 510
            ..|.|        |....::.|.|:........:|:            |..||
Human   313 GIDFNTIIRTSPTSLVAYINGSRASPANLSPQPEVYGHFLGVRGSCIPQPRPVPGSQKGVLVAPG 377

  Fly   511 ---------ESAKDHQQMTE------EP------------------------TNSTKRKRGRKER 536
                     :.|.:|::|.:      :|                        |...:...|....
Human   378 GLALPAYGEDGALEHERMQQLEHGGLQPGLVNHMVVQHGLPGPDSQSAGLFKTERLEEFPGSTVD 442

  Fly   537 KSPTPVLIPLGDKEIKEEPELPERRMRKSR--QHVDYVVEIKDEEEDDDEVEEAEVDDDSSATIS 599
            ..|.|.|.||........|......:....  .|...:.           :.:|.:|||
Human   443 LPPAPPLPPLPPPPGPPPPYHAHAHLHHPELGPHAQQLA-----------LPQATLDDD------ 490

  Fly   600 PHNSSTDESFTSIKRESSEESQHNGIGGIHTCNF--CGKTFKRFSRMQDHL-RLHTGEK---PYV 658
                                .:.:||||.|.|.:  |...:.:...:..|: ::|..::   .:.
Human   491 --------------------GEMDGIGGKHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFT 535

  Fly   659 CGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKC--DKCNKG 721
            |...|                 ..:.||      |...:..|.:|||.|..::..||  :.|.|.
Human   536 CFWAG-----------------CPRRYK------PFNARYKLLIHMRVHSGEKPNKCTFEGCEKA 577

  Fly   722 FVRSSDLSIHVRIHTGEKPYSCDL--CGKAFRARQNLVVHRRTHLGDKPIQCEL--CDKRFARKI 782
            |.|..:|.||:|.|||||||.|..  |.|||....:...|:||||..||..|::  |.||:....
Human   578 FSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPS 642

  Fly   783 DMRVHMRRHTGEKPY-----------------NC-------------DACQRG------------ 805
            .:|.|::.|:.::..                 :|             ||...|
Human   643 SLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDL 707

  Fly   806 YSSRVNLLRHQERE----------HGIEEQVPGSGQADKKHTKTA-----TENEQENEPKAKAAP 855
            ||:.:....:..|.          |.:....||.......|..::     |..:...|..|.:||
Human   708 YSAPIFSSNYSSRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPSAP 772

  Fly   856 R----RPRREKLQQKIAAQEKLLNDLKRSLSAMPEIPE-ESAQVKLDGSGQDIPADAGAGHAQVQ 915
            .    .|||      :.|...:|...:...:..|.... :|.|.:.:.|.|.........:.|:|
Human   773 SPHHISPRR------VPAPSSILQRTQPPYTQQPSGSHLKSYQPETNSSFQPNGIHVHGFYGQLQ 831

  Fly   916 VTLSMQMEPAPNTEDDEEITP 936
                 :..| |:..|.:.|.|
Human   832 -----KFCP-PHYPDSQRIVP 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	53/204 (26%)
		C2H2 Zn finger	631..651	CDD:275368	3/22 (14%)
		C2H2 Zn finger	715..735	CDD:275368	9/21 (43%)
		C2H2 Zn finger	743..763	CDD:275368	7/21 (33%)
		C2H2 Zn finger	771..791	CDD:275368	6/21 (29%)
		zf-H2C2_2	783..808	CDD:463886	8/66 (12%)
		C2H2 Zn finger	799..816	CDD:275370	6/41 (15%)
GLIS3	NP_001035878.1	SFP1	<558..652	CDD:227516	38/93 (41%)
		C2H2 Zn finger	569..591	CDD:275368	9/21 (43%)
		C2H2 Zn finger	599..621	CDD:275368	7/21 (33%)
		C2H2 Zn finger	629..651	CDD:275368	6/21 (29%)