Protein Alignment Phs and ZNF558

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_653294.1
• Gene: ZNF558 / 148156
• HGNCID: 26422
• Length: 402
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 120/400 - (30%)
• Similarity: 180/400 - (45%)
• Gaps: 37/400 - (9%)

  Fly   431 SAQKSETNPKHLENAETNS----KDNTESVALKETIHDKQLTIDEAGKAGTQKDDNSNQKQLDKS 491
            |.||..|....|.|....|    ....|.||::.| .::...:|.|.:...:.....|.:.|...
Human    19 SQQKGHTQGGELVNELLTSWLRGLVTFEDVAVEFT-QEEWALLDPAQRTLYRDVMLENCRNLASL 82

  Fly   492 EANAGKSKMVDQVHQQMPV---------ESAKDHQQMTEEPTNSTKRKRGRKERKSPTPVLIPLG 547
            .....|..::.|:.|...|         .:..|.:.:.:....:.|:...|||:
Human    83 GCRVNKPSLISQLEQDKKVVTEERGILPSTCPDLETLLKAKWLTPKKNVFRKEQ----------- 136

  Fly   548 DKEIKEEPELPERRMRKSRQHVDYVVEIKDEEEDDDEVEEAEVDDDSSATISPHN-SSTDESFTS 611
            .|.:|.|......::.:..|... |...|........:...|         .|:: |...:||:|
Human   137 SKGVKTERSHRGVKLNECNQCFK-VFSTKSNLTQHKRIHTGE---------KPYDCSQCGKSFSS 191

  Fly   612 IKRESSEESQHNGIGGIHTCNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQCGRAFRLKMRLVEHQ 676
            ....:..:..||| ...:.||.|||.|...|.::.|||:|||||||.|.||...||....|..|:
Human   192 RSYLTIHKRIHNG-EKPYECNHCGKAFSDPSSLRLHLRIHTGEKPYECNQCFHVFRTSCNLKSHK 255

  Fly   677 LRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSDLSIHVRIHTGEKPY 741
            ..|..|..::|:.|....:|:..|:.|...|..::.|:|..|.|.|.:||.|:.|||.|||||||
Human   256 RIHTGENHHECNQCGKAFSTRSSLTGHNSIHTGEKPYECHDCGKTFRKSSYLTQHVRTHTGEKPY 320

  Fly   742 SCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVHMRRHTGEKPYNCDACQRGY 806
            .|:.|||:|.:..:|.||:|.|.|:||.:|..|.|.|.....::.|:|.|||||||.|:.|.:.:
Human   321 ECNECGKSFSSSFSLTVHKRIHTGEKPYECSDCGKAFNNLSAVKKHLRTHTGEKPYECNHCGKSF 385

  Fly   807 SSRVNLLRHQ 816
            :|...|..|:
Human   386 TSNSYLSVHK 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	75/193 (39%)
		C2H2 Zn finger	631..651	CDD:275368	10/19 (53%)
		C2H2 Zn finger	715..735	CDD:275368	10/19 (53%)
		C2H2 Zn finger	743..763	CDD:275368	9/19 (47%)
		C2H2 Zn finger	771..791	CDD:275368	6/19 (32%)
		zf-H2C2_2	783..808	CDD:463886	11/24 (46%)
		C2H2 Zn finger	799..816	CDD:275370	4/16 (25%)
ZNF558	NP_653294.1	KRAB	43..100	CDD:214630	11/57 (19%)
		C2H2 Zn finger	154..174	CDD:275368	3/20 (15%)
		COG5048	<162..398	CDD:227381	91/243 (37%)
		C2H2 Zn finger	182..202	CDD:275368	4/19 (21%)
		C2H2 Zn finger	210..230	CDD:275368	10/19 (53%)
		C2H2 Zn finger	238..258	CDD:275368	7/19 (37%)
		C2H2 Zn finger	266..286	CDD:275368	5/19 (26%)
		C2H2 Zn finger	294..314	CDD:275368	10/19 (53%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	5/17 (29%)