Protein Alignment Phs and ZNF599

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_001007249.1
• Gene: ZNF599 / 148103
• HGNCID: 26408
• Length: 588
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 156/601 - (25%)
• Similarity: 236/601 - (39%)
• Gaps: 128/601 - (21%)

  Fly   320 LTMINDMVAVIAAER------VKKTSSSKVN----KMIIKL--PMPK----------------KR 356
            |....|:|.....|.      .::|...:|.    ::::.|  |:||                ||
Human     8 LVSFEDVVVTFTGEEWGHLDLAQRTLYQEVMLETCRLLVSLGHPVPKPELIYLLEHGQELWTVKR 72

  Fly   357 GRKRTKPESLRDEQDNAEKTDKKKKLNKEEGQQPVLEPLQAKKTSNQAENG-ATQSNNVVKVQQN 420
            |..::.....:.:....|.|..:...::|...|.:|    |:::|..:..| |.....::|:|:
Human    73 GLSQSTCAGEKAKPKITEPTASQLAFSEESSFQELL----AQRSSRDSRLGQARDEEKLIKIQE- 132

  Fly   421 AKGSKKDGTQSAQKSETNPKHL--ENAETNSKDNTESVALKETIHDKQLTIDEAGKAGTQKD--D 481
              |:.:.||.  ...|..|:.|  ::.:....|:.....|:|.: ..|..:.|....|..||  .
Human   133 --GNLRPGTN--PHKEICPEKLSYKHDDLEPDDSLGLRVLQERV-TPQDALHECDSQGPGKDPMT 192

  Fly   482 NSNQKQLDKSEANAGKSKMVDQV-HQQMPV--------ESAKDHQQMT-----------EEPTNS 526
            ::.......:|...|.||....| |||:..        |..|..:.|.           |:|...
Human   193 DARNNPYTCTECGKGFSKKWALVRHQQIHAGVKPYECNECGKACRYMADVIRHMRLHTGEKPYKC 257

  Fly   527 TKRKRGRKERKSPTP-VLIPLGDK--EIKEEPELPERRMRKSRQHVDYVVE--IKDEEEDDDEVE 586
            .:..:..|.|...|. ..|..|||  |.||        ..|:..|....::  :....|.....:
Human   258 IECGKAFKRRFHLTEHQRIHTGDKPYECKE--------CGKAFTHRSSFIQHNMTHTREKPFLCK 314

  Fly   587 EAEVDDDSSATISPHN-----------SSTDESFTSIKRESSEESQHNGIGGIHT------CNFC 634
            |.......|::.:.|.           ....::||    ..|...|||   ..||      |..|
Human   315 ECGKAFYYSSSFAQHMRIHTGKKLYECGECGKAFT----HRSTFIQHN---VTHTGEKPFLCKEC 372

  Fly   635 GKTFKRFSRMQDHLRLHTGEKPYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQD 699
            ||||...|....|:|:|||||||.||:||:||..:...:.|:..|..||.::|..|.........
Human   373 GKTFCLNSSFTQHMRIHTGEKPYECGECGKAFTHRSTFIRHKRTHTGEKPFECKECGKAFCDSSS 437

  Fly   700 LSLHMRHHKNDRRYKCDKCNKGFVR----------------------------SSDLSIHVRIHT 736
            |..|||.|..::.|:|.:|.|.|..                            ||..:.|:||||
Human   438 LIQHMRIHTGEKPYECSECGKAFTHHSVFIRHNRTHSGQKPLECKECAKAFYYSSSFTRHMRIHT 502

  Fly   737 GEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVHMRRHTGEKPYNCDA 801
            |||||.|..|||||....|.|.|.|.|.|:||.:|:.|:|.|.....:..|||.||||||:.|:.
Human   503 GEKPYVCRECGKAFTQPANFVRHNRIHTGEKPFECKECEKAFCDNFALTQHMRTHTGEKPFECNE 567

  Fly   802 CQRGYSSRVNLLRHQE 817
            |.:.:|...:...|::
Human   568 CGKTFSHSSSFTHHRK 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	78/237 (33%)
		C2H2 Zn finger	631..651	CDD:275368	9/19 (47%)
		C2H2 Zn finger	715..735	CDD:275368	8/47 (17%)
		C2H2 Zn finger	743..763	CDD:275368	10/19 (53%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		zf-H2C2_2	783..808	CDD:463886	11/24 (46%)
		C2H2 Zn finger	799..816	CDD:275370	3/16 (19%)
ZNF599	NP_001007249.1	KRAB	9..69	CDD:214630	9/59 (15%)
		C2H2 Zn finger	201..221	CDD:275368	8/19 (42%)
		C2H2 Zn finger	229..249	CDD:275368	3/19 (16%)
		COG5048	253..>580	CDD:227381	105/341 (31%)
		C2H2 Zn finger	257..277	CDD:275368	3/19 (16%)
		C2H2 Zn finger	285..305	CDD:275368	4/27 (15%)
		C2H2 Zn finger	313..333	CDD:275368	3/19 (16%)
		C2H2 Zn finger	341..361	CDD:275368	6/26 (23%)
		C2H2 Zn finger	369..389	CDD:275368	9/19 (47%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		C2H2 Zn finger	453..473	CDD:275368	4/19 (21%)
		C2H2 Zn finger	481..501	CDD:275368	4/19 (21%)
		C2H2 Zn finger	509..529	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..585	CDD:275368	4/19 (21%)