DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phs and Gli3

DIOPT Version :10

Sequence 1:NP_648789.3 Gene:Phs / 39697 FlyBaseID:FBgn0036522 Length:971 Species:Drosophila melanogaster
Sequence 2:NP_032156.2 Gene:Gli3 / 14634 MGIID:95729 Length:1583 Species:Mus musculus


Alignment Length:997 Identity:188/997 - (18%)
Similarity:309/997 - (30%) Gaps:313/997 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 ESDMEEEEEDEEDEEEDDLPDVALQIDSEDEAELEAQRIRLVEEEAAKTTKKAEKERQQLQQKQQ 91
            |:........|..:.|:.:.....:.|..::|            .|:.||...::...|:..:::
Mouse     2 EAQAHSSTATERKKAENSIGKCPTRTDVSEKA------------VASSTTSNEDESPGQIYHRER 54

  Fly    92 R-----QAQVSNGNEEQLEETQKPSNNKRKARGRPKRKISTS-SQASSASIASSATLVAAQ---- 146
            |     |.|...|..:..||   ||.:..:.....|::|..| ...:..|:....|:.|..    
Mouse    55 RNAITMQPQSVQGLNKISEE---PSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTVFAMDPRNG 116

  Fly   147 ------------------VLADQKSRRFIYSCTSCTHHYDDNLILSRHF-----------QLEHV 182
                              |..|.:.....|       |||.:.|...|.           .|..:
Mouse   117 YMEPHYHPPHLFPAFHPPVPIDARHHEGRY-------HYDPSPIPPLHVPSALSSSPTYPDLPFI 174

  Fly   183 EKSKRKRGKTKAAAEEPMVTPPLIIDPLEMGQLKPCAQLLVQGESVLQLCLACNSQFVDVVRFQE 247
            ..|..:  ...||:|.|...|...|:|. |..::.    |....|:..:..|......|......
Mouse   175 RISPHR--NPTAASESPFSPPHPYINPY-MDYIRS----LHSSPSLSMISAARGLSPTDAPHAGV 232

  Fly   248 HLSQQHGYFQLLVPKEEP-TDLPPHAMVTIPGALALNKANAQLQLPIPAPE---TPPPEQDGKEA 308
            ..::.:....||..:..| .|:.|.|.....||:.:...:|......|:|.   .|..::....:
Mouse   233 SPAEYYHQMALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSIS 297

  Fly   309 PPSNASNDKEDLTMI----NDMVAVIAAERVKKTSSSKVNKMIIKLPMPKKRGRKRTKPESLRDE 369
            |.|:.|.|.:  |||    |.:|.::...|...::|.....:......|.......:.|.||...
Mouse   298 PLSDHSFDLQ--TMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHMH 360

  Fly   370 QDNAEKTDKKKKLNKEEGQQ-PVLEPLQAKKTSNQAENGATQSNNV-VKVQQNAKGSKKDGTQSA 432
            |   :...:::.|....|.. |::.|.....|........|..|.| |....:.....|..::||
Mouse   361 Q---QILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQSKPTSESA 422

  Fly   433 QKSETNPKHLENAETNSKDNTESVALKETIHDKQLTIDEAGKAGTQKDDNSNQKQLDKSEANAGK 497
            ..|..:|.|                                                        
Mouse   423 VSSTGDPMH-------------------------------------------------------- 431

  Fly   498 SKMVDQVHQQMPVESAKDHQQMTEEPTNSTKRKRGRKERKSPTPVLIPLGDKEIKEEPELPERRM 562
                                         .||.:.:.:...|:|     |.:..:|:||      
Mouse   432 -----------------------------NKRSKIKPDEDLPSP-----GSRGQQEQPE------ 456

  Fly   563 RKSRQHVDYVVEIKDEEEDDDEVEEAEVDDDSSATISPHNSSTDESFTSIKRESSEESQHNGIGG 627
                    ....:|:|.:.|:..:|.||..:           |:..:....||...:.|.     
Mouse   457 --------GTTLVKEEADKDESKQEPEVIYE-----------TNCHWEGCTREFDTQDQL----- 497

  Fly   628 IHTCNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSM 692
            :|..|            .||  :|..:|.:||                                 
Mouse   498 VHHIN------------NDH--IHGEKKEFVC--------------------------------- 515

  Fly   693 PLATKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSDLSIHVRIHTGEKPYSCDL--CGKAFRARQN 755
                              |...|.:..|.|.....|.:|:|.||||||:.|..  |.||:...:|
Mouse   516 ------------------RWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLEN 562

  Fly   756 LVVHRRTHLGDKPIQCEL--CDKRFARKIDMRVHMRR-HTGEKPYNC--DACQRGYSSRVNLLRH 815
            |..|.|:|.|:||..||.  |:|.|:...|...|..| |:.||||.|  ..|.:.|:...:|.:|
Mouse   563 LKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKH 627

  Fly   816 QEREHGIEEQVPGSGQADKKHTKTATENEQENEPKAKAAPRRPRREKLQQKIAAQEKLLNDLKRS 880
            .:..||.|..|....:.| .|.:.....:..:..::: :|.||    .|.....|::|.|...:.
Mouse   628 VKTVHGPEAHVTKKQRGD-MHPRPPPPRDSGSHSQSR-SPGRP----TQGAFGEQKELSNTTSKR 686

  Fly   881 LSAMPEIPEESAQVKLDGSGQDIPADAGAGHAQVQVTLSMQMEPAPNTED--------------- 930
                    ||..|||...:.:.:.:....|.   |.:.|.|..|..|..:               
Mouse   687 --------EECLQVKTVKAEKPMTSQPSPGG---QSSCSSQQSPISNYSNSGLELPLTDGGSVAD 740

  Fly   931 ----DEEITPEKENALSSSMTA 948
                ||  ||..::.:|::.||
Mouse   741 LSAIDE--TPIMDSTISTATTA 760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhsNP_648789.3 COG5048 <594..787 CDD:227381 43/196 (22%)
C2H2 Zn finger 631..651 CDD:275368 3/19 (16%)
C2H2 Zn finger 715..735 CDD:275368 6/19 (32%)
C2H2 Zn finger 743..763 CDD:275368 8/21 (38%)
C2H2 Zn finger 771..791 CDD:275368 8/22 (36%)
zf-H2C2_2 783..808 CDD:463886 11/27 (41%)
C2H2 Zn finger 799..816 CDD:275370 4/18 (22%)
Gli3NP_032156.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78 17/90 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 368..475 27/210 (13%)
SFP1 <542..632 CDD:227516 34/89 (38%)
C2H2 Zn finger 548..570 CDD:275368 8/21 (38%)
C2H2 Zn finger 578..601 CDD:275368 8/22 (36%)
C2H2 Zn finger 609..630 CDD:275368 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 620..728 26/124 (21%)
Mediates interaction with DZIP1. /evidence=ECO:0000269|PubMed:23955340 745..845 7/18 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..828
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..918
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1164..1189
Blue background indicates that the domain is not in the aligned region.

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