Protein Alignment Phs and Gli3

DIOPT Version :10

• Sequence 1: NP_648789.3
• Gene: Phs / 39697
• FlyBaseID: FBgn0036522
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_536330.2
• Gene: Gli3 / 140588
• RGDID: 620272
• Length: 1582
• Species: Rattus norvegicus
• Alignment Length: 997
• Identity: 188/997 - (18%)
• Similarity: 308/997 - (30%)
• Gaps: 313/997 - (31%)

  Fly    27 ESDMEEEEEDEEDEEEDDLPDVALQIDSEDEAELEAQRIRLVEEEAAKTTKKAEKERQQLQQKQQ 91
            |:........|..:.|..:.....:.|..::|            .|:.||...::...|:..:::
  Rat     2 EAQSHSSTTTERKKAESSIAKCPTRTDVSEKA------------VASSTTSNEDESAGQIYHRER 54

  Fly    92 R-----QAQVSNGNEEQLEETQKPSNNKRKARGRPKRKISTS-SQASSASIASSATLVAAQ---- 146
            |     |.|...|..:..||   ||.:..:.....|::|..| ...:..|:....|:.|..
  Rat    55 RNAITMQPQSVQGLSKISEE---PSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTVFAMDPRNG 116

  Fly   147 ------------------VLADQKSRRFIYSCTSCTHHYDDNLILSRHF-----------QLEHV 182
                              |..|.:.....|       |||.:.|...|.           .|..:
  Rat   117 YMEPHYHPPHLFPAFHPPVPIDARHHEGRY-------HYDPSPIPPLHVPSALSSSPTYPDLPFI 174

  Fly   183 EKSKRKRGKTKAAAEEPMVTPPLIIDPLEMGQLKPCAQLLVQGESVLQLCLACNSQFVDVVRFQE 247
            ..|..:  ...||:|.|...|...|:|. |..::.    |....|:..:..|......|......
  Rat   175 RISPHR--NPTAASESPFSPPHPYINPY-MDYIRS----LHSSPSLSMISAARGLSPTDAPHAGV 232

  Fly   248 HLSQQHGYFQLLVPKEEP-TDLPPHAMVTIPGALALNKANAQLQLPIPAPE---TPPPEQDGKEA 308
            ..::.:....||..:..| .|:.|.|.....||:.:...:|......|:|.   .|..::....:
  Rat   233 SPAEYYHQMALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSIS 297

  Fly   309 PPSNASNDKEDLTMI----NDMVAVIAAERVKKTSSSKVNKMIIKLPMPKKRGRKRTKPESLRDE 369
            |.|:.|.|.:  |||    |.:|.::...|...::|.....:......|.......:.|.||...
  Rat   298 PLSDHSFDLQ--TMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHMH 360

  Fly   370 QDNAEKTDKKKKLNKEEGQQ-PVLEPLQAKKTSNQAENGATQSNNV-VKVQQNAKGSKKDGTQSA 432
            |   :...:::.|....|.. |::.|.....|........|..|.| |....:.....|..::||
  Rat   361 Q---QILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQSKPTSESA 422

  Fly   433 QKSETNPKHLENAETNSKDNTESVALKETIHDKQLTIDEAGKAGTQKDDNSNQKQLDKSEANAGK 497
            ..|..:|.|
  Rat   423 VSSTGDPMH-------------------------------------------------------- 431

  Fly   498 SKMVDQVHQQMPVESAKDHQQMTEEPTNSTKRKRGRKERKSPTPVLIPLGDKEIKEEPELPERRM 562
                                         .||.:.:.:...|:|     |.:..:|:||
  Rat   432 -----------------------------NKRSKIKPDEDLPSP-----GSRGQQEQPE------ 456

  Fly   563 RKSRQHVDYVVEIKDEEEDDDEVEEAEVDDDSSATISPHNSSTDESFTSIKRESSEESQHNGIGG 627
                    ....:|:|.:.|:..:|.||..:           |:..:....||...:.|.
  Rat   457 --------GTTLVKEEGDKDESKQEPEVIYE-----------TNCHWEGCTREFDTQDQL----- 497

  Fly   628 IHTCNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSM 692
            :|..|            .||  :|..:|.:||
  Rat   498 VHHIN------------NDH--IHGEKKEFVC--------------------------------- 515

  Fly   693 PLATKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSDLSIHVRIHTGEKPYSCDL--CGKAFRARQN 755
                              |...|.:..|.|.....|.:|:|.||||||:.|..  |.||:...:|
  Rat   516 ------------------RWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLEN 562

  Fly   756 LVVHRRTHLGDKPIQCEL--CDKRFARKIDMRVHMRR-HTGEKPYNC--DACQRGYSSRVNLLRH 815
            |..|.|:|.|:||..||.  |:|.|:...|...|..| |:.||||.|  ..|.:.|:...:|.:|
  Rat   563 LKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKH 627

  Fly   816 QEREHGIEEQVPGSGQADKKHTKTATENEQENEPKAKAAPRRPRREKLQQKIAAQEKLLNDLKRS 880
            .:..||.|..|....:.| .|.:.....:..:..::: :|.||    .|.....|::|.|...:.
  Rat   628 VKTVHGPEAHVTKKQRGD-MHPRPPPPRDSGSHSQSR-SPGRP----TQGAFGEQKELSNTTSKR 686

  Fly   881 LSAMPEIPEESAQVKLDGSGQDIPADAGAGHAQVQVTLSMQMEPAPNTED--------------- 930
                    ||..|||...:.:.:.:....|.   |.:.|.|..|..|..:
  Rat   687 --------EECLQVKTVKAEKPMTSQPSPGG---QSSCSSQQSPISNYSNSGLELPLTDGGSIAD 740

  Fly   931 ----DEEITPEKENALSSSMTA 948
                ||  ||..::.:|::.||
  Rat   741 LSAIDE--TPIMDSTISTATTA 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	43/196 (22%)
		C2H2 Zn finger	631..651	CDD:275368	3/19 (16%)
		C2H2 Zn finger	715..735	CDD:275368	6/19 (32%)
		C2H2 Zn finger	743..763	CDD:275368	8/21 (38%)
		C2H2 Zn finger	771..791	CDD:275368	8/22 (36%)
		zf-H2C2_2	783..808	CDD:463886	11/27 (41%)
		C2H2 Zn finger	799..816	CDD:275370	4/18 (22%)
Gli3	NP_536330.2	SFP1	<542..632	CDD:227516	34/89 (38%)
		C2H2 Zn finger	548..570	CDD:275368	8/21 (38%)
		C2H2 Zn finger	578..601	CDD:275368	8/22 (36%)
		C2H2 Zn finger	609..630	CDD:275368	5/20 (25%)