DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phs and ZNF559-ZNF177

DIOPT Version :10

Sequence 1:NP_648789.3 Gene:Phs / 39697 FlyBaseID:FBgn0036522 Length:971 Species:Drosophila melanogaster
Sequence 2:NP_001371588.1 Gene:ZNF559-ZNF177 / 100529215 HGNCID:42964 Length:481 Species:Homo sapiens


Alignment Length:492 Identity:139/492 - (28%)
Similarity:205/492 - (41%) Gaps:102/492 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   409 TQSNNVVKVQQNAKGSKKDG---TQSAQKSETNPKHLENAETNSKDNTESV-------ALKETIH 463
            |.|.|.|..|:.|....::.   ...|||:......|||..     |..||       :|...:.
Human     8 TWSQNSVTFQEVAVDFSQEEWALLDPAQKNLYKDVMLENFR-----NLASVGYQLCRHSLISKVD 67

  Fly   464 DKQLTIDEAGKAGTQKDDNSNQKQLDKSEANA------GKSKMVDQVHQQMPVESAKDHQQMTEE 522
            .:||..||.|.  .|.|....:.||...:..|      ||:.......:..|.|.:.:.....:.
Human    68 QEQLKTDERGI--LQGDCADWETQLKPKDTIAMQNIPGGKTSNGINTAENQPGEHSLECNHCGKF 130

  Fly   523 PTNS----TKRKRGRKERK---------SPTP----VLIPLGDKEIK---------EEPELPERR 561
            ..|:    |:..:|.|..|         .|:.    |.|.:|:|.::         :|..|    
Human   131 RKNTRFICTRYCKGEKCYKYIKYSKVFNHPSTLRSHVSIHIGEKTLEFTDCRKAFNQESSL---- 191

  Fly   562 MRKSRQHVDYVVEIKDEEEDD--------------DEVEEAEVDDDSS--ATISPHNSST----- 605
                |:|:......|.:|.:.              :::...|..|:.|  ..|||.:..|     
Human   192 ----RKHLRTPTGQKFQEYEQCDMSFSLHSSCSVREQIPTGEKGDECSDYGKISPLSVHTKTGSV 252

  Fly   606 ---------DESFTS-------IKRESSEESQHNGIGGIHTCNFCGKTFKRFSRMQDHLRLHTGE 654
                     :::||.       ::..|.|..        :.|:.|||.|...|.::.|:|.||||
Human   253 EEGLECNEHEKTFTDPLSLQNCVRTHSGEMP--------YECSDCGKAFIFQSSLKKHMRSHTGE 309

  Fly   655 KPYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCN 719
            |||.|..||::|.....|..|:..|..||.|.|..|.........|..|:|.|..::.|:|..|.
Human   310 KPYECDHCGKSFSQSSHLNVHKRTHTGEKPYDCKECGKAFTVPSSLQKHVRTHTGEKPYECSDCG 374

  Fly   720 KGFVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDM 784
            |.|:..|.|..|.|.|||||||.|:.|||:|.....|:||:|||.|:|..:|:.|.|.|.....:
Human   375 KAFIDQSSLKKHTRSHTGEKPYECNQCGKSFSTGSYLIVHKRTHTGEKTYECKECGKAFRNSSCL 439

  Fly   785 RVHMRRHTGEKPYNCDACQRGYSSRVNLLRHQEREHG 821
            |||:|.|||||||.|..|::.:|:..||:.|:...:|
Human   440 RVHVRTHTGEKPYKCIQCEKAFSTSTNLIMHKRIHNG 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhsNP_648789.3 COG5048 <594..787 CDD:227381 74/215 (34%)
C2H2 Zn finger 631..651 CDD:275368 8/19 (42%)
C2H2 Zn finger 715..735 CDD:275368 8/19 (42%)
C2H2 Zn finger 743..763 CDD:275368 9/19 (47%)
C2H2 Zn finger 771..791 CDD:275368 8/19 (42%)
zf-H2C2_2 783..808 CDD:463886 13/24 (54%)
C2H2 Zn finger 799..816 CDD:275370 5/16 (31%)
ZNF559-ZNF177NP_001371588.1 KRAB 14..70 CDD:214630 13/60 (22%)
C2H2 Zn finger 124..142 CDD:275368 2/17 (12%)
C2H2 Zn finger 150..170 CDD:275368 2/19 (11%)
C2H2 Zn finger 178..197 CDD:275368 4/26 (15%)
COG5048 <212..442 CDD:227381 76/237 (32%)
C2H2 Zn finger 258..278 CDD:275368 2/19 (11%)
C2H2 Zn finger 286..306 CDD:275368 8/19 (42%)
C2H2 Zn finger 314..334 CDD:275368 6/19 (32%)
C2H2 Zn finger 342..362 CDD:275368 5/19 (26%)
C2H2 Zn finger 370..390 CDD:275368 8/19 (42%)
C2H2 Zn finger 398..418 CDD:275368 9/19 (47%)
C2H2 Zn finger 426..446 CDD:275368 8/19 (42%)
zf-H2C2_2 439..463 CDD:463886 13/23 (57%)
C2H2 Zn finger 454..474 CDD:275368 6/19 (32%)

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