DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7650 and PDCL

DIOPT Version :9

Sequence 1:	NP_648786.1	Gene:	CG7650 / 39694	FlyBaseID:	FBgn0036519	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_005379.3	Gene:	PDCL / 5082	HGNCID:	8770	Length:	301	Species:	Homo sapiens

Alignment Length:	286	Identity:	127/286 - (44%)
Similarity:	180/286 - (62%)	Gaps:	23/286 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATLEDKLLGEKLEYYCSSSEGEDNGDEGGDNKGASGKSRCSGLTIDTNPDATPAGGFRQQSSTN 65
            |.||:||||||||:||.||||.||:..|..|      :.||:..:.....:|..||   :..|.|
Human     1 MTTLDDKLLGEKLQYYYSSSEDEDSDHEDKD------RGRCAPASSSVPAEAELAG---EGISVN 56

  Fly    66 TGPKGVVKDWQRFKQLEAERRDETERQRLALAKKLTITATTSA-EDEERKRQEELDAELDELMS- 128
            ||||||:.||:||||||.|:|:|..|:...|.|||::|..:.. |:||:::|::|..::...|:
Human    57 TGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMTCRSHLDEEEEQQKQKDLQEKISGKMTL 121

  Fly   129 ------------EDFLQQYQKQRMAEMLRQTGHHQQFGQVQQLTSHEEFLACVEQENKHTTIIIH 181
                        |:|||||:||||.||.:|.....||.||.:::|.|.||..:::|.|...|::|
Human   122 KEFAIMNEDQDDEEFLQQYRKQRMEEMRQQLHKGPQFKQVFEISSGEGFLDMIDKEQKSIVIMVH 186

  Fly   182 IYERQLAACATLNKCLDSLASDYPSIKFAKICSSVAGMSRDFRTKGLPALLVYKAQAVIGNFVRL 246
            |||..:.....:|.|:..||::||::||.|:.|||.|.|..|....|||||:||...:||||||:
Human   187 IYEDGIPGTEAMNGCMICLAAEYPAVKFCKVKSSVIGASSQFTRNALPALLIYKGGELIGNFVRV 251

  Fly   247 TDDLSDDFFASDVESFLIEHGIIVDR 272
            ||.|.|||||.|:|:||.|.|::.::
Human   252 TDQLGDDFFAVDLEAFLQEFGLLPEK 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7650	NP_648786.1	Phd_like_Phd	60..267	CDD:239285	100/220 (45%)
PDCL	NP_005379.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..57		14/47 (30%)
		Phosducin	36..299	CDD:251094	104/245 (42%)
		Phd_like_Phd	51..272	CDD:239285	100/220 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158653
Domainoid	1	1.000	194	1.000	Domainoid score	I3177
eggNOG	1	0.900	-	-		E1_KOG3171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38043
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3456
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55912
OrthoDB	1	1.010	-	-		D1324495at2759
OrthoFinder	1	1.000	-	-		FOG0002881
OrthoInspector	1	1.000	-	-		oto90942
orthoMCL	1	0.900	-	-		OOG6_105152
Panther	1	1.100	-	-	LDO	PTHR46052
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4364
SonicParanoid	1	1.000	-	-		X2239
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800