DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7656 and UBE2Z

DIOPT Version :9

Sequence 1:	NP_648783.4	Gene:	CG7656 / 39691	FlyBaseID:	FBgn0036516	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_075567.2	Gene:	UBE2Z / 65264	HGNCID:	25847	Length:	354	Species:	Homo sapiens

Alignment Length:	339	Identity:	78/339 - (23%)
Similarity:	126/339 - (37%)	Gaps:	83/339 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AGSGSLATSSSAAAPTT-TPSSSAVRALAM---------------------------EYKSLQEE 55
            |.:|......|..||.. .|.|:|....|:                           :..|:.:|
Human    50 AAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKE 114

  Fly    56 PVEGFRVKLINDD-NLFEWEVAIFGPPDTLYQGGYFKAHMKFPHDYPYSPPSIRFLTK-----VW 114
            |..|..|  :.|. ::.:....|.||.||.|:||:|....:.|.|||..||.::.:|.     .:
Human   115 PPPGMFV--VPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRF 177

  Fly   115 HPNVYENGDLCISILHPPVDDPQSGELPCERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVM 179
            :||.|.||.:|:|||         |......|:|.|::.::|:|:.||:.|    :|.:.:....
Human   178 NPNFYRNGKVCLSIL---------GTWTGPAWSPAQSISSVLISIQSLMTE----NPYHNEPGFE 229

  Fly   180 YRRWRDSQGKDNEYPNIIRKQALAANAEAKREGIVVPMTLEDYCLKPTRKPTTESGLDANFYDDD 244
            ..|   ..|....|...||.:.:       |..:...|..:..|.:|.|....:|.|:   |.|.
Human   230 QER---HPGDSKNYNECIRHETI-------RVAVCDMMEGKCPCPEPLRGVMEKSFLE---YYDF 281

  Fly   245 FDLETEDDLPSDDDFDEDDDDDEDEDEDEDSATAPISKNNGG---SSKCKNNGLVREAAAAGA-- 304
            :::..:|.|.......:|                |..:..|.   .|.....||:|:......
Human   282 YEVACKDRLHLQGQTMQD----------------PFGEKRGHFDYQSLLMRLGLIRQKVLERLHN 330

  Fly   305 DDAESADDSGKGET 318
            ::||...||....|
Human   331 ENAEMDSDSSSSGT 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7656	NP_648783.4	UBCc	42..186	CDD:238117	43/176 (24%)
CG7656	NP_648783.4	COG5078	45..182	CDD:227410	42/169 (25%)
UBE2Z	NP_075567.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		UBCc	103..221	CDD:238117	40/132 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..354		5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910