DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AIMP2 and AIMP2

DIOPT Version :9

Sequence 1:	NP_648782.2	Gene:	AIMP2 / 39690	FlyBaseID:	FBgn0036515	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_006294.2	Gene:	AIMP2 / 7965	HGNCID:	20609	Length:	320	Species:	Homo sapiens

Alignment Length:	350	Identity:	89/350 - (25%)
Similarity:	141/350 - (40%)	Gaps:	86/350 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYELKTLLP------QFDIKLPTCMYPLKNVSLAADSLASGSSTSASTSASTSSCKLEANRIDRT 59
            ||::|   |      ...::||||||.|.||    ...:.|.:..|......|:..|:|
Human     3 MYQVK---PYHGGGAPLRVELPTCMYRLPNV----HGRSYGPAPGAGHVQEESNLSLQA------ 54

  Fly    60 GRNAATCALDLDSLGRQIQRLLKDDTASVAARQEKVLKQLEELKAQLGQIR-------AGLGVCG 117
                                        :.:||:.:||:|.||||.:..:.       |.|.|..
Human    55 ----------------------------LESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTN 91

  Fly   118 --KTFQHTTAFQNG-------GLKEVPLQDVVINGHPNFIPYALLALKNAWRNLYTIDVKTFTHS 173
              :..:.||...|.       |.....|:|:|||.:|...|.:||.|.......:.:.....|||
Human    92 IIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHS 156

  Fly   174 TMADIGPAAREFEANLAKV--PVNPALPK----ISVTLIWKNCEHTEMISSPTMYVPIYGEVNII 232
            ::..:       ..||.|.  ..|...|:    :..||||||...|:|..|.....||.||.||.
Human   157 SVKSV-------PENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIA 214

  Fly   233 RYLGRVGPAEYRYEGSPLCNEIDLVLDICYQLLRCNTHKTQVAMVRLLDKRLQKQQYFGGSQMSV 297
            |:|..:...::....:.|   ||..:||....|:..:.|.:.|:.|.::..|.|..:..|::::|
Human   215 RFLFSLFGQKHNAVNATL---IDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTV 276

  Fly   298 ADVGVYSSL-------IRMPAVTEK 315
            |||.::|.|       :.:||..::
Human   277 ADVVLWSVLQQIGGCSVTVPANVQR 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AIMP2	NP_648782.2	GST_C_family	<275..327	CDD:198286	13/47 (28%)
AIMP2	NP_006294.2	AIMP2_LysRS_bd	1..33	CDD:293385	13/35 (37%)
		Interaction with PRKN. /evidence=ECO:0000269\|PubMed:16135753	82..162		26/95 (27%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:18695251	162..225		17/68 (25%)
		GST_C_AIMP2	214..309	CDD:198309	29/101 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N3G
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I5316
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49981
OrthoDB	1	1.010	-	-		D1382507at2759
OrthoFinder	1	1.000	-	-		FOG0007974
OrthoInspector	1	1.000	-	-		oto89277
orthoMCL	1	0.900	-	-		OOG6_108313
Panther	1	1.100	-	-	LDO	PTHR13438
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9405
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.800