Protein Alignment CG12301 and UTP14C

DIOPT Version :10

• Sequence 1: NP_648781.1
• Gene: CG12301 / 39689
• FlyBaseID: FBgn0036514
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_067677.4
• Gene: UTP14C / 9724
• HGNCID: 20321
• Length: 766
• Species: Homo sapiens
• Alignment Length: 806
• Identity: 221/806 - (27%)
• Similarity: 383/806 - (47%)
• Gaps: 121/806 - (15%)

  Fly     1 MSDDEEHYE---PKAHKKLLQAIGSLGKVQHIQKSTRDERQSLQDEFQLVKGVSSAETDHAPRAV 62
            :|::|:..:   .:.|:|||:||.||......:.:.|.|......||       |..::.:...:
Human    27 LSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEF-------SVSSEGSGEKL 84

  Fly    63 GLNDLVDILRTSTKHSQTGKKLKNIHGSKKVLQKPLEKPAADRIKRTIGYEGVTKKLGRWDAVVA 127
            ||.||::.::||:..:...|:|..:. ||||::.||.|...::|.|.:.:...::.|.:||.::.
Human    85 GLADLLEPVKTSSSLATVKKQLNRVK-SKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIIL 148

  Fly   128 QQRSAETQIFPLPSETVYVNTAANARPLNTRVKSNLAQELEANNRKLRELRKAQIGDTTDEKELA 192
            :.:.||..:|||..|...:....:|.. ..:.::.|.||:    ..|....|..:.|..    |.
Human   149 KNQQAEQLVFPLGKEQPAIAPIEHALS-GWKARTPLEQEI----FNLLHKNKQPVTDPL----LT 204

  Fly   193 KQERLLLQKKLTRDELFARRKELAYLKMRESQKSAKARMQNKIKSKKFHKLQKRQKMLEQMKEFE 257
            ..|:..|| .::.:|....|.||...:..:|...||||.:.||||||:||:.|:.|..:.:||||
Human   205 PMEKASLQ-AMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFE 268

  Fly   258 LLQKTDPEAALEKLNALEKSRVQERASLRHKNTGTWAKNLQIRAKYDKDVRKDLAEQLAVSRELT 322
            .|||.:|..|||::..:|.:|:.||.||:|:|:|.|||:..|.||||.:.|:.:.||||.::|||
Human   269 QLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELT 333

  Fly   323 QKKQV-SDSEDE----TTKKRVLP---EEEDNDYDPFNPWTKRKATEQTENGNGESEGSNWRQYW 379
            ||.|| |:||:|    ..::.::|   .|...:.|..|||..|..|..|:....:.:.....:
Human   334 QKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPE-- 396

  Fly   380 TKRNKNEKLLEEHRRDLEGVQDNDEQEEKETIRKPLIEVKPAKKKLKKSKVKIENGWEVEDICPT 444
                     |..|.......::....||:..:|    |.:..:...|:|::.       :|..|.
Human   397 ---------LAAHEVSASEAEERPVAEEEILLR----EFEERQSLRKRSELN-------QDAEPA 441

  Fly   445 DQKEAKASPNSKAIDDIFEKHEDHIRAKLNKKMEKLRERINKL-----------------KEVPV 492
            ..:|.|.|.:.:.:.:        :||...|..||.:.|..|.                 :..|:
Human   442 SSQETKDSSSQEVLSE--------LRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPL 498

  Fly   493 KGKKAKKKDVLQNLKSLALKKTKQQIEIDEP-LNYEEDKNSQNNIPAHVEGNTE----------- 545
            ..:::::...|:.|:.|..:...|..|:..| |..::.:.:.||.|...:...|
Human   499 LLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFL 563

  Fly   546 STEIPAVDTIDPNKVTTLVFTQKKGNSGGFNDALIDDEAAEYDEEDAAAERQLTISQAFEDDDIV 610
            :|:.|:|.::   .|.|::                    .|.::|:...:||: |.:||..||::
Human   564 TTQSPSVRSL---AVPTII--------------------EELEDEEERDQRQM-IKEAFAGDDVI 604

  Fly   611 ADFNRDKSKDSEL-KNTELQLALPGWGSWAGAGISKEVMERRNKRLLLKLAAPE--KRRDENKDN 672
            .||.::|.:..|. |..::.|.|||||.|.|.|:.....:||  :.|:|  |||  .|:|:|..|
Human   605 RDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRR--QFLIK--APEGPPRKDKNLPN 665

  Fly   673 LYLNESASKQARQHMVSSIPFPFRSLADYEASIRAPVGRNFVPETAFRMLTRPAVITRKGQVIEP 737
            :.::|..:..|..|.|..:|:||.....:|.:|:.|:|..:..:.||:.||.|.|:|:.|.:|:|
Human   666 VIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGHIIKP 730

  Fly   738 MTESEL--VKPDRRLRHIVDRRIKRI 761
            :...::  ....|....::.|..|||
Human   731 IKAEDVGYQSSSRSDLPVIQRNPKRI 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12301	NP_648781.1	Utp14	15..738	CDD:461368	212/762 (28%)
UTP14C	NP_067677.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..42		2/14 (14%)
		Utp14	43..734	CDD:461368	213/766 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..563		39/227 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	734..766		5/23 (22%)