DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12301 and SPAC57A7.06

DIOPT Version :9

Sequence 1:	NP_648781.1	Gene:	CG12301 / 39689	FlyBaseID:	FBgn0036514	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_593375.1	Gene:	SPAC57A7.06 / 2542351	PomBaseID:	SPAC57A7.06	Length:	929	Species:	Schizosaccharomyces pombe

Alignment Length:	796	Identity:	209/796 - (26%)
Similarity:	354/796 - (44%)	Gaps:	146/796 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DDEEHYEPKAHKKLLQAIGSLGKVQHIQKSTRDERQS----LQDEFQLVKGVSSAETDHAP---- 59
            ||.|:.:.|. ..|...|.||.     ||..:||..:    ..|:...::.:|..:..:.|
pombe   216 DDGENSDSKL-DNLRNYIVSLN-----QKRKKDEADAESVLSSDDNDSIEEISIKKVKYDPHETN 274

  Fly    60 -----RAVGLN----DLVDILRTSTKHSQTGKKLKNIHG-----SKKVLQKPLEKPAADRIKRTI 110
                 ..:|.:    |:.|:|.:...:.|....||.:..     |.|.|..||.|...||::|..
pombe   275 KESEYNLIGSSEKTIDITDLLDSIPMNEQLKVSLKPLVSESSSISSKKLDAPLAKSIQDRLERQA 339

  Fly   111 GYEGVTKKLGRWDAVVAQQRSAETQIFPLPSETVYVNTAANARPLNTRVKSN--LAQELEANNRK 173
            .||.....|.:|..:||..|.::..|||: :||        |||    |.||  ||...|.....
pombe   340 AYEQTKNDLEKWKPIVADNRKSDQLIFPM-NET--------ARP----VPSNNGLASSFEPRTES 391

  Fly   174 LRELRKAQI-GDTTDEKELAKQERLLLQKKLTRDELFARRKELAYLKMRESQKSAKARMQNKIKS 237
            .|::.:|.: ....:|..|.|||.|.| .||:.:|:..|.::|.:::....::..||:...||||
pombe   392 ERKMHQALLDAGLENESALKKQEELAL-NKLSVEEVAERTRQLRFMRELMFREERKAKRVAKIKS 455

  Fly   238 KKFHKLQKRQKMLEQMKEFELLQKTDPEAALEKLNALEKSRVQERASLRHKNTGTWAKNLQIRAK 302
            |.:.|::|.:|    .||..|:.|::.:...|::.: |::|..||.:.|||||.:|.:.:..||.
pombe   456 KTYRKIRKNRK----EKEMALIPKSEEDLENERIKS-EEARALERMTQRHKNTSSWTRKMLERAS 515

  Fly   303 YDKDVRKDLAEQLAVSRELTQK---KQVSDSEDETTKKRVLPEEEDNDYDPFNPWTKRKATEQTE 364
            :.:..|:.:.||:....||.|:   |::|:.:.|.     :.|..|:|||     |..:.:...|
pombe   516 HGEGTREAVNEQIRKGDELMQRIHGKEISEMDGED-----VSEFSDSDYD-----TNEQVSTAFE 570

  Fly   365 NGNGESE-------GSNWRQYWTKRNKNEKLLEEHRR----DLEGVQDNDEQEEKETIRKPLIEV 418
            ....|.|       |..:.:  ...|:.:.|:::..:    :|.||.:.|:..:|.....|.:.:
pombe   571 KIRNEEEPKLKGVLGMKFMR--DASNRQKALVQDEMQAFEDELAGVPNEDDTSQKGEDGVPGVLI 633

  Fly   419 ---------KPAKKKLKKSKVKIENGWEVED--ICPTDQKEAKASPNSKAIDDIFEKHEDHIRAK 472
                     ||:::..|.|....:|.: |.|  :...::.|.|               |...:|:
pombe   634 GNNTGRRSFKPSEEAAKLSLPSRKNPF-VSDSAVLKVNKPEMK---------------EGQKKAE 682

  Fly   473 LNKKME---KLRERINKLKEVPVKGKKAKKKDVLQNLKSLALKKTKQQIEIDEPLNYEEDKNSQN 534
            ..||.|   :..|..|...:||.:...:.||  |....|.|.|| ..::::|:..:.:|
pombe   683 ARKKKESPLEATEETNPWLQVPDQRTSSAKK--LDKNSSKADKK-NHKLKMDKVASLQE------ 738

  Fly   535 NIPAHVEGNTESTEIPAVDTIDPNKVTTLVFTQKKGNSGGFNDALIDDEAAEYDEED---AAAER 596
                .||              :|.....|:|.:|...|....::.:|..........   :..:|
pombe   739 ----LVE--------------EPKVQPDLIFEEKAFESASEAESDVDVSVPMLKPTKGRLSIKQR 785

  Fly   597 QLTISQAFEDDDIVADFNRDKSKD--SELKNTELQLALPGWGSWAGAGISKEVMERRNKRLLLKL 659
            :| :::||..||:||:|.:|| :|  .|....|...:|||||||.|.|    |.:|:.|..:.|:
pombe   786 EL-VAKAFAGDDVVAEFEKDK-EDWVQEDAPKEEDHSLPGWGSWGGVG----VKQRKTKPKVKKI 844

  Fly   660 AA--PEKRRDENKDNLYLNESASKQARQHMVSSIPFPFRSLADYEASIRAPVGRNFVPETAFRML 722
            |.  |.||:|....::.:||..:|:|.:....|:||||.|...||.|:..|:|..:....:....
pombe   845 AGLDPSKRKDSKLKHVIINEKRNKKAAKLTADSVPFPFESREQYERSLNLPMGPEWTTRASHHKA 909

  Fly   723 TRPAVITRKGQVIEPM 738
            ..|.|:|::|:||.|:
pombe   910 VAPRVVTKRGKVINPI 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12301	NP_648781.1	Utp14	2..738	CDD:282471	208/794 (26%)
SPAC57A7.06	NP_593375.1	COG5644	10..929	CDD:227931	209/796 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	200	1.000	Domainoid score	I658
eggNOG	1	0.900	-	-		E1_COG5644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I999
OMA	1	1.010	-	-		QHG53823
OrthoFinder	1	1.000	-	-		FOG0002569
OrthoInspector	1	1.000	-	-		oto101745
orthoMCL	1	0.900	-	-		OOG6_102803
Panther	1	1.100	-	-	LDO	PTHR14150
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2331
SonicParanoid	1	1.000	-	-		X1926
TreeFam	1	0.960	-	-
	13	12.860