DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12301 and Utp14b

DIOPT Version :9

Sequence 1:	NP_648781.1	Gene:	CG12301 / 39689	FlyBaseID:	FBgn0036514	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_001001981.2	Gene:	Utp14b / 195434	MGIID:	2445092	Length:	780	Species:	Mus musculus

Alignment Length:	795	Identity:	209/795 - (26%)
Similarity:	349/795 - (43%)	Gaps:	147/795 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDDEEHYEPKA-HKKLLQAIGSLGKVQHIQKSTRDERQSLQDEFQLVKGVSSAETDHAPRAVGLN 65
            |:||...:.:. .:|||:|:.|||:....:.:.|.|...:..||.:....|..:.
Mouse    55 SEDEGDSDGEGKRQKLLEAVSSLGRKNKWKLAERSEASRMVSEFNVTSEGSGEKL---------- 109

  Fly    66 DLVDILRTSTKHSQTGKKLKNIHGSK-KVLQKPLEKPAADRIKRTIGYEGVTKKLGRWDAVVAQQ 129
            .|.|:|.::|..|......|.:|..| |.|..||.|..|||..|...:...::.|.|||.||.:.
Mouse   110 VLSDLLGSATALSSVAAVKKQLHRVKSKTLTPPLNKEEADRALREAAFSKTSQMLSRWDPVVLKN 174

  Fly   130 RSAETQIFPL--------PSETVYVNTAANARPLNTRVKSNLAQELE-ANNRKLRELRKAQIGDT 185
            |.||..|||:        |.|.|:.:..... ||...|.:.|.:..: ..:..|..:..|.|
Mouse   175 RQAEQLIFPMEKEPPAVAPIEHVFTDWKVRT-PLEREVFNLLHKNKQPVTDPLLTPVETASI--- 235

  Fly   186 TDEKELAKQERLLLQKKLTRDELFARRKELAYLKMRESQKSAKARMQNKIKSKKFHKLQKRQKML 250
                           :.::.:|...||.||...:..:|...|:||.:.:|||||:|:..|:.|..
Mouse   236 ---------------RAMSLEEAKIRRAELQRTRALQSYYEARARREKRIKSKKYHRALKKGKAK 285

  Fly   251 EQMKEFELLQKTDPEAALEKLNALEKSRVQERASLRHKNTGTWAKNLQIRAKYDKDVRKDLAEQL 315
            :.:||||.|.|..|.|||::|..:||:|:.||.||:|:.:|.|||:..|.||||.:.||.:.|||
Mouse   286 KALKEFEELWKDCPNAALQELEKMEKARMTERMSLKHQGSGKWAKSKAIMAKYDPEARKAMQEQL 350

  Fly   316 AVSRELTQKKQV---SDSEDETTKKRVLPEEEDND-----YDPFNPWTKRKATEQTENGNGESEG 372
            |.:||||||.||   |:.||..|::.::......|     .|..|||.........:.|..:::.
Mouse   351 AKNRELTQKLQVVSESEEEDGCTEEGIVSVSHGMDDLQMNADGVNPWMLSSCNSNAKRGEIKTDP 415

  Fly   373 SNWRQYWTKRNKNEKLLEEHRRDLEGVQDNDEQEEKETIRKPLIEVKPAKKKLKKSKVKIENGWE 437
            ....::                 :..|....|.:|:....:.:::.:..::::..:..|:.:|.|
Mouse   416 EQMPEF-----------------VAHVSSESEGDERPVAEELVLKERSFQERVDPNNAKLMDGQE 463

  Fly   438 VED-----ICPTDQKEAKASPNSKAIDD---IFEKHEDHIRAKL--NKKMEKL-----RERINKL 487
            .||     :.....||:..|.|.|...:   :..:.||....||  .:::|:.     :..::|.
Mouse   464 TEDSDSQEVLQKLNKESHQSDNQKVSSEENVLHIQREDLASEKLLVLQRLERAHVLEQQGELSKE 528

  Fly   488 KEVPVKG-KKAKKKDVLQNLKSL-------ALKKTKQQIEIDEPLNYEEDKNSQNNIPAHVEGNT 544
            :..|.|| .:...|...:.:|.|       ..||.:|.|::...|       :.|:.|      .
Mouse   529 EHYPKKGLSRPLLKGDWKEMKPLTNPDASGGKKKKEQMIDLRNLL-------TANSSP------V 580

  Fly   545 ESTEIPAVDTIDPNKVTTLVFTQKKGNSGGFNDALIDDEAAEYDEEDAAAERQLTISQAFEDDDI 609
            .|..:|.:..:                                 |::...:.:..|.:||..||:
Mouse   581 RSLAVPTIQQL---------------------------------EDEVETDHKQLIREAFAGDDV 612

  Fly   610 VADFNRDKSKDSEL-KNTELQLALPGWGSWAGAGISKEVMERRNKRLLLKLAAPEKRRDENKDNL 673
            :.:|.::|.:..|. |..:|.|:|||||.|.|.|:.....:||  |.|:|......|:|:|..|:
Mouse   613 IREFLKEKREAIETNKPKDLDLSLPGWGEWVGMGLKPSAKKRR--RFLIKAPESSPRKDKNLPNV 675

  Fly   674 YLNESASKQARQHMVSSIPFPFRSLADYEASIRAPVGRNFVPETAFRMLTRPAVITRKGQVIEPM 738
            .::|..:..|..|.|.::|.||.....:|.:|:.|:|..:..:..|:.||.|.|.|:.|.:|:|:
Mouse   676 IISEKRNIHAAAHQVRALPHPFTHQQQFERTIQNPIGYMWNTQRTFQKLTVPKVGTKLGHIIKPI 740

  Fly   739 ----------TESEL 743
                      |.|:|
Mouse   741 KAENVGYCSSTRSDL 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12301	NP_648781.1	Utp14	2..738	CDD:282471	205/778 (26%)
Utp14b	NP_001001981.2	Utp14	55..741	CDD:282471	206/779 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841924
Domainoid	1	1.000	276	1.000	Domainoid score	I1725
eggNOG	1	0.900	-	-		E1_COG5644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2912
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53823
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002569
OrthoInspector	1	1.000	-	-		otm43883
orthoMCL	1	0.900	-	-		OOG6_102803
Panther	1	1.100	-	-	O	PTHR14150
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2331
SonicParanoid	1	1.000	-	-		X1926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790