DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12301 and F27C1.6

DIOPT Version :9

Sequence 1:	NP_648781.1	Gene:	CG12301 / 39689	FlyBaseID:	FBgn0036514	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_491590.1	Gene:	F27C1.6 / 172192	WormBaseID:	WBGene00017855	Length:	647	Species:	Caenorhabditis elegans

Alignment Length:	797	Identity:	207/797 - (25%)
Similarity:	344/797 - (43%)	Gaps:	205/797 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDDEEHYEPKAHKKLLQAIGSLGKVQ--HIQKS--TRDERQSLQDEFQLVKGVSSAETDHAPRA 61
            ||||.: .:..||:||||:|.:.|.|:  .::|:  |:.:..||.....    ||...|:.|.::
Worm     1 MSDDSD-LDDVAHQKLLQSIHTPGTVKKNRLKKASKTKTDATSLLSHLT----VSRPSTNKAKQS 60

  Fly    62 VGLNDLVDILRTSTK--------HSQTGKKLKNIHGSKKVLQKPL-EKPAADRIKRTIGYEGVTK 117
            :|:..|....:|..|        .:.|.||||    ||.::  || :..|...|:..|.:..:.|
Worm    61 LGIGGLESTEKTGKKRKSEATADETTTKKKLK----SKTLI--PLKDVEARKEIEGKIAFTDLKK 119

  Fly   118 KLGR-WDAVVAQQRSAETQIFPL--PSETVYVNTAANARPLNTRVKSNLAQELEANNRKLRELRK 179
            ::.: |..:|...|.::..||||  |...::
Worm   120 EVTQNWTELVQSNRVSDQLIFPLTKPDGIMW---------------------------------- 150

  Fly   180 AQIGDTTDEKELAKQERLLLQK---KLTRDELFARRKELAYLKMRESQKSAKARMQNKIKSKKFH 241
               ||...|..|.::|..|::.   |:.:|.|...::..|.:.::|    ||.|...|||||.:|
Worm   151 ---GDEKTEPVLTEKEMELMKATDIKMAKDRLSQMQRMRAIVGIQE----AKNRYMKKIKSKGYH 208

  Fly   242 KLQKRQKMLEQMKEFELLQKTDPEAALEKLNALEKSRVQERASLRHKNTGTWAKN-LQIRAKYDK 305
            ::.||:|..:.:|||:.|...||.||.|||..::..|:.||.||:|:......|. |:..|..:.
Worm   209 RILKREKRKQLLKEFDDLVARDPSAAHEKLAEMDLQRIMERGSLKHRGQNQKFKQMLEKHASRNP 273

  Fly   306 DVRKDLAEQLAVSRELTQKKQVSDSEDETTKKRVLPEEEDND-------YDPFNPWTKRKATEQT 363
            :|:|.|.|.|.:.|||              |.:|....||:|       .||.|  .|:...|..
Worm   274 EVKKLLDEHLRMGREL--------------KAKVATTAEDSDGEAPTSTEDPQN--KKKSIHELI 322

  Fly   364 ENGNGESEGSNWRQYWTKRNKNEKLLEEHRRDLEGVQDNDEQEEKETIRKPLIEVKPAKKKLKKS 428
            ::...|:|..:.:|..|      .|::..      ::|:|.|           :|..|:.:.||
Worm   323 KDAAQEAEKESRKQVGT------ALVDTF------LEDSDAQ-----------KVTLAQMRAKK- 363

  Fly   429 KVKIENGWEVEDICPTDQKEA----KASPNSKA--------IDDIFEKHEDHIRAKLNKKMEKLR 481
                             ::||    ..|.|:.|        :||.:::.||..:||..||
Worm   364 -----------------RQEAAITRSISANTGASRENPLFDVDDTWQEKEDAKKAKQKKK----- 406

  Fly   482 ERINKLKEVPVKGKKAKKKDVLQNLKSLALKKTKQQIEIDEPLNYEEDKNSQNNIPAHVEGNTES 546
             ::.|.||...||...|...|.:|.        ..::|......::|          .||...:|
Worm   407 -KLLKAKESARKGTIGKVSYVDKNY--------DPKMEAKRAETFDE----------KVEKAVDS 452

  Fly   547 TEIPAVD------TIDPNKVTTLVFTQKKGNSGGFNDALID--DEAAEYDEEDAAAERQLTISQA 603
            ..:.|.:      .|||:|...|       |:........|  ::..::|||.|.     .|::|
Worm   453 AGVHAAEKRQKEIEIDPSKFLEL-------NTNDLTQVSSDFVEKMDQFDEEAAQ-----VINEA 505

  Fly   604 FEDDDIVADFN--RDKSKDSE-LKNTELQLALPGWGSWAGAGISKEVMERRNKRLLLKLAAPEKR 665
            |:|||::.||.  ::..|:.| :|:.:|.||  |||||.|.|:::   ::|.:..::|  |.|||
Worm   506 FKDDDVIGDFEDMKEGVKEKEKVKDVDLNLA--GWGSWVGPGMTE---KKRRQNFVIK--AKEKR 563

  Fly   666 RDENKDN---LYLNESASKQARQHMVSSIPFPFRSLADYEASIRAPVGRNFVPETAFRMLTRPAV 727
            |.:.:.|   :..|.:|.....:....|:|||:..:.||||.::.|:|..:..|.....|.:|||
Worm   564 RRDGERNGVIIAENMTAKDGIGKIQPRSLPFPYSRVEDYEAVLKQPLGLEWNMEKMRDELCKPAV 628

  Fly   728 ITRKGQVIEPMTESELV 744
            :...|:.|.|:.:..|:
Worm   629 VVEAGRAIRPINKKHLL 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12301	NP_648781.1	Utp14	2..738	CDD:282471	204/788 (26%)
F27C1.6	NP_491590.1	Utp14	2..639	CDD:282471	204/788 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2842
Isobase	1	0.950	-	0	Normalized mean entropy	S3627
OMA	1	1.010	-	-		QHG53823
OrthoDB	1	1.010	-	-		D370022at2759
OrthoFinder	1	1.000	-	-		FOG0002569
OrthoInspector	1	1.000	-	-		oto17548
orthoMCL	1	0.900	-	-		OOG6_102803
Panther	1	1.100	-	-	LDO	PTHR14150
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2331
SonicParanoid	1	1.000	-	-		X1926
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.790