DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12301 and UTP14A

DIOPT Version :9

Sequence 1:	NP_648781.1	Gene:	CG12301 / 39689	FlyBaseID:	FBgn0036514	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_006640.2	Gene:	UTP14A / 10813	HGNCID:	10665	Length:	771	Species:	Homo sapiens

Alignment Length:	817	Identity:	236/817 - (28%)
Similarity:	397/817 - (48%)	Gaps:	135/817 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDDE-EHYEPKAHKKLLQAIGSLGKVQHIQKSTRDERQSLQDEFQLVKGVSSAETDHAPRAVGLN 65
            |:|| ::...:.|:|||:||.||......:.:.|.|......||    .|||   :.:...:.|.
Human    31 SEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLKVSEF----NVSS---EGSGEKLVLA 88

  Fly    66 DLVDILRTSTKHSQTGKKLKNIHGSKKVLQKPLEKPAADRIKRTIGYEGVTKKLGRWDAVVAQQR 130
            ||::.::||:..:...|:|..:. |||.::.||.|...:||.|.:.:....:.|.:||.||.:.|
Human    89 DLLEPVKTSSSLATVKKQLSRVK-SKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNR 152

  Fly   131 SAETQIFPLPSETVYVNTAANARPL-----NTRVKSNLAQELEANNRKLRELRKAQIGDTTDEKE 190
            .||..:|||..|...:      .|:     ..:.::.|.||:    ..|....|..:.|..
Human   153 QAEQLVFPLEKEEPAI------APIEHVLSGWKARTPLEQEI----FNLLHKNKQPVTDPL---- 203

  Fly   191 LAKQERLLLQKKLTRDELFARRKELAYLKMRESQKSAKARMQNKIKSKKFHKLQKRQKMLEQMKE 255
            |...|:..| :.::.:|...||.||...:..:|...||||.:.||||||:||:.|:.|..:.:||
Human   204 LTPVEKASL-RAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKE 267

  Fly   256 FELLQKTDPEAALEKLNALEKSRVQERASLRHKNTGTWAKNLQIRAKYDKDVRKDLAEQLAVSRE 320
            ||.|:|.:|.||||:|..:||:|:.||.||:|:|:|.|||:..|.||||.:.|:.:.|||:.::|
Human   268 FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKE 332

  Fly   321 LTQKKQV-SDSED-----ETTKKRVLPE---EEDNDYDPFNPWTKRKATEQTENGNGESEGSNWR 376
            ||||.|| |:||:     |..::.::|:   |...:.|..|||..|..|..|:....:.:
Human   333 LTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED----- 392

  Fly   377 QYWTKRNKNEKL--LEEHRRDLEGVQDNDEQE----EKETIRKPLIEVKPAKKKLKKSKVKIENG 435
                    .|:|  ||.|     ||.:::.:|    |:|.:.:...|.:..:|:.:.|
Human   393 --------PEQLPELEAH-----GVSESEGEERPVAEEEILLREFEERRSLRKRSELS------- 437

  Fly   436 WEVEDICPTDQKEAKASPNSKAIDD---IFEKHEDHIRAKLNKKMEK------LRERINKLKEVP 491
               :|..|...:|.|.|.:.:.:.:   :.:|.:::.:::..|...:      .||.....:|.|
Human   438 ---QDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEP 499

  Fly   492 VKGKKAKKKDVLQNLKSLALKKTKQQIEIDEP-LNYEEDKNSQNNIP-AHVE----------GNT 544
            :..::.::...|:.|:.|..::..|..|:..| |..::.:.:.||.| |..|          .|.
Human   500 LLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNL 564

  Fly   545 ESTEIPAVDTIDPNKVTTLVFTQKKGNSGGFNDALIDDEAAEYDEEDAAAERQLTISQAFEDDDI 609
            .:|:.|:|.::   .|.|:                     .|.::|:....||: |.:||..||:
Human   565 LTTQSPSVKSL---AVPTI---------------------EELEDEEERNHRQM-IKEAFAGDDV 604

  Fly   610 VADFNRDKSKDSEL-KNTELQLALPGWGSWAGAGISKEVMERRNKRLLLKLAAPE--KRRDENKD 671
            :.||.::|.:..|. |..::.|.|||||.|.|.|:.....:||  |.|:|  |||  .|:|:|..
Human   605 IRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRR--RFLIK--APEGPPRKDKNLP 665

  Fly   672 NLYLNESASKQARQHMVSSIPFPFRSLADYEASIRAPVGRNFVPETAFRMLTRPAVITRKGQVIE 736
            |:.:||..:..|..|.|..:|:||.....:|.:|:.|:|..:..:.||:.||.|.|:|:.|.:|.
Human   666 NVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGHIIN 730

  Fly   737 PM----------TESELVKPDRRLRHIVDRRIKRIPK 763
            |:          :.|:|....|..:.|..|..|::.|
Human   731 PIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLKK 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12301	NP_648781.1	Utp14	2..738	CDD:282471	228/780 (29%)
UTP14A	NP_006640.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..49		7/17 (41%)
		Utp14	29..733	CDD:309659	229/781 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..355		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..557		43/217 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..771		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151803
Domainoid	1	1.000	280	1.000	Domainoid score	I1689
eggNOG	1	0.900	-	-		E1_COG5644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2883
Isobase	1	0.950	-	0	Normalized mean entropy	S3627
OMA	1	1.010	-	-		QHG53823
OrthoDB	1	1.010	-	-		D370022at2759
OrthoFinder	1	1.000	-	-		FOG0002569
OrthoInspector	1	1.000	-	-		otm41833
orthoMCL	1	0.900	-	-		OOG6_102803
Panther	1	1.100	-	-	LDO	PTHR14150
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720