DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mrn and GTF2H4

DIOPT Version :9

Sequence 1:	NP_648780.1	Gene:	mrn / 39688	FlyBaseID:	FBgn0261109	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001508.1	Gene:	GTF2H4 / 2968	HGNCID:	4658	Length:	462	Species:	Homo sapiens

Alignment Length:	474	Identity:	241/474 - (50%)
Similarity:	321/474 - (67%)	Gaps:	22/474 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GQGPANLECKDFQEYLRTRQTPESLEKLYNYPPICLAVFRELPEIARQFIIRILFVDQPVPQAVV 90
            |....:|:|::.||:| ...:|..|::||.:|..|||||||||.:|:.:::|:||::||:|||.|
Human     8 GLNRVHLQCRNLQEFL-GGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRMLFLEQPLPQAAV 71

  Fly    91 TSWGAQRCAKEQAEATSCLTALNVWRVTAIPGGLSAWELSPTFKKSVRQVLLGGGKPW-PMTNTL 154
            ..|..:..:|.|.|:|..|:.|.:|....:||||....|:|.|::::|..||||||.| ..|:.|
Human    72 ALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRIALLGGGKAWSDDTSQL 136

  Fly   155 DKDSKPRDIAFLDTYAMSRWRCVLHYMVGTGNRNGTDAEAISPDAVRILLHANLMKRDE-RDGIT 218
            ..|...||:..||.||..||..|||:||      |:.:.|:|.|..::|..|.|||..| .:...
Human   137 GPDKHARDVPSLDKYAEERWEVVLHFMV------GSPSAAVSQDLAQLLSQAGLMKSTEPGEPPC 195

  Fly   219 ITRQGFQFLLLDTRAQVWHFMLQYLDTCEERGISLPECLSMLFQLSFSTLGRDYSSEGMNSQMLT 283
            ||..|||||||||.||:|:||||||.|.:.||:.|.|.||.||||||||||:|||.|||:..:|.
Human   196 ITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQLSFSTLGKDYSVEGMSDSLLN 260

  Fly   284 FLQHLREFGLVFQRKRKEGRFYPTRLALNVTSKEAAATASVAMDEEATQDCGYIVVETNYRVYAY 348
            |||||||||||||||||..|:||||||:|::|..:.|..:|       ...|:||||||||:|||
Human   261 FLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGTV-------HQPGFIVVETNYRLYAY 318

  Fly   349 TDSPLQVAVLGLFTELLYRFPNLVVGVLTRDSVRQALRGGITAEQIVSYLEQYAHPNMRMVESAI 413
            |:|.||:|::.||:|:||||||:||..:||:||:||:..||||:||:.:|...|||.|      :
Human   319 TESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFLRTRAHPVM------L 377

  Fly   414 HSKSCLPPTVVDQIKLWELERNRFTYTEGVLYNQFLSHTDFVTLRDYAQSIHMLVWQNERTRTMV 478
            .....||||:.|||:||||||:|..:|||||||||||..||..|..:|:.:.:||::|...|.||
Human   378 KQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFENSAKRLMV 442

  Fly   479 VQKNGHDDVKRYWKKYSKS 497
            |...||.||||:||:...|
Human   443 VTPAGHSDVKRFWKRQKHS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mrn	NP_648780.1	Tfb2	39..403	CDD:281797	188/365 (52%)
GTF2H4	NP_001508.1	tfb2	18..460	CDD:273180	237/461 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151747
Domainoid	1	1.000	369	1.000	Domainoid score	I915
eggNOG	1	0.900	-	-		E1_COG5144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7090
Inparanoid	1	1.050	462	1.000	Inparanoid score	I1561
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54356
OrthoDB	1	1.010	-	-		D433426at33208
OrthoFinder	1	1.000	-	-		FOG0004312
OrthoInspector	1	1.000	-	-		oto89132
orthoMCL	1	0.900	-	-		OOG6_101881
Panther	1	1.100	-	-	LDO	PTHR13152
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1501
SonicParanoid	1	1.000	-	-		X3583
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800