DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mrn and Gtf2h4

DIOPT Version :9

Sequence 1:	NP_648780.1	Gene:	mrn / 39688	FlyBaseID:	FBgn0261109	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_997666.1	Gene:	Gtf2h4 / 294236	RGDID:	1303309	Length:	463	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	242/474 - (51%)
Similarity:	322/474 - (67%)	Gaps:	22/474 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GQGPANLECKDFQEYLRTRQTPESLEKLYNYPPICLAVFRELPEIARQFIIRILFVDQPVPQAVV 90
            |...|:|:|::.||:| ...:|..|::||.:|..|||||||||.:|:.:::|:||::||:|||.|
  Rat     9 GLNRAHLQCRNLQEFL-GGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRMLFLEQPLPQAAV 72

  Fly    91 TSWGAQRCAKEQAEATSCLTALNVWRVTAIPGGLSAWELSPTFKKSVRQVLLGGGKPW-PMTNTL 154
            ..|..:..:|.|.|:|..|:.|.:|....:||||....|:|.|::::|..||||||.| ..|:.|
  Rat    73 ALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPVFRQNLRIALLGGGKAWSDDTSQL 137

  Fly   155 DKDSKPRDIAFLDTYAMSRWRCVLHYMVGTGNRNGTDAEAISPDAVRILLHANLMKRDE-RDGIT 218
            ..|...||:..||.||..||..|||:||      |:.:.|:|.|..::|..|.|||..| .:...
  Rat   138 GPDKHARDVPSLDKYAEERWEVVLHFMV------GSPSAAVSQDLAQLLSQAGLMKSTEPGEPPC 196

  Fly   219 ITRQGFQFLLLDTRAQVWHFMLQYLDTCEERGISLPECLSMLFQLSFSTLGRDYSSEGMNSQMLT 283
            ||..|||||||||.||:|:||||||.|.:.||:.|.|.||.||||||||||:|||.|||:..:|.
  Rat   197 ITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQLSFSTLGKDYSVEGMSDSLLN 261

  Fly   284 FLQHLREFGLVFQRKRKEGRFYPTRLALNVTSKEAAATASVAMDEEATQDCGYIVVETNYRVYAY 348
            |||||||||||||||||..|:||||||:|::|..:.|..:|       ...|:||||||||:|||
  Rat   262 FLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGTV-------HQPGFIVVETNYRLYAY 319

  Fly   349 TDSPLQVAVLGLFTELLYRFPNLVVGVLTRDSVRQALRGGITAEQIVSYLEQYAHPNMRMVESAI 413
            |:|.||:|::.||:|:||||||:||..:||:||:||:..||||:||:.:|...|||.|      :
  Rat   320 TESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFLRTRAHPVM------L 378

  Fly   414 HSKSCLPPTVVDQIKLWELERNRFTYTEGVLYNQFLSHTDFVTLRDYAQSIHMLVWQNERTRTMV 478
            .....||||:.|||:||||||:|..:|||||||||||..||..|..:|:.:.:||::|...|.||
  Rat   379 KQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFENSAKRLMV 443

  Fly   479 VQKNGHDDVKRYWKKYSKS 497
            |...||.||||:||:...|
  Rat   444 VTPAGHSDVKRFWKRQKHS 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mrn	NP_648780.1	Tfb2	39..403	CDD:281797	188/365 (52%)
Gtf2h4	NP_997666.1	tfb2	19..461	CDD:273180	237/461 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345234
Domainoid	1	1.000	369	1.000	Domainoid score	I883
eggNOG	1	0.900	-	-		E1_COG5144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7090
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1482
OMA	1	1.010	-	-		QHG54356
OrthoDB	1	1.010	-	-		D433426at33208
OrthoFinder	1	1.000	-	-		FOG0004312
OrthoInspector	1	1.000	-	-		oto96262
orthoMCL	1	0.900	-	-		OOG6_101881
Panther	1	1.100	-	-	LDO	PTHR13152
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3583
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770