DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mrn and tfb2

DIOPT Version :9

Sequence 1:	NP_648780.1	Gene:	mrn / 39688	FlyBaseID:	FBgn0261109	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_596563.1	Gene:	tfb2 / 2539790	PomBaseID:	SPBC13G1.13	Length:	447	Species:	Schizosaccharomyces pombe

Alignment Length:	468	Identity:	182/468 - (38%)
Similarity:	249/468 - (53%)	Gaps:	45/468 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DFQEYLRTRQTPESLEKLYNYPPICLAVFRELPEIARQFIIRILFVDQPVPQAVVTSWGAQRCAK 100
            ||.|.|...      .:||..|..||||||.||.:|||:::.:||...||..:....|.......
pombe    11 DFLEQLPNH------ARLYQKPAACLAVFRLLPILARQYVMSMLFNPMPVALSDFDLWIKLSSKV 69

  Fly   101 EQAEATSCLTALNVWR-----VTAIPGGLSAWELSPTFKKSVRQVLLGGGK----PWPMTNTLDK 156
            .|:|:.:.|..:::::     :|          |:..|:|.....|.|||.    ..|.|   |:
pombe    70 YQSESFNKLVRMHIFQFDGQYIT----------LNSEFRKQFITALTGGGNHNSFGVPCT---DE 121

  Fly   157 DSKPRDIAFLDTYAMSRWRCVLHYMVGTGNRNGTDAEAISP-DAVRILLHANLMKRDERDGITIT 220
            |.....:.|||.||...|..:||:||||       .||..| :.|..||....:....::.:.||
pombe   122 DKHLVTVDFLDAYAKETWETILHFMVGT-------PEAKFPGEGVLSLLKRGGLMSGPKNQLRIT 179

  Fly   221 RQGFQFLLLDTRAQVWHFMLQYLDTCEERGISLPECLSMLFQLSFSTLGRDYSSEGMNSQMLTFL 285
            |.||||||.|..||:|..:|.||...|:..:...:.|..||.|....|||.||.:.:.......|
pombe   180 RAGFQFLLQDINAQIWTLLLDYLKLSEDTHMDPVQVLHFLFMLGSLDLGRAYSVDFLTDTQQIML 244

  Fly   286 QHLREFGLVFQRKRKEGRFYPTRLALNVTSKEAAATASVAMDEEATQDCGYIVVETNYRVYAYTD 350
            :.|||:|||:|||....||||||||..:|:...:....   ..|...|.|:|:||||||:||||.
pombe   245 EDLREYGLVYQRKITSKRFYPTRLATGLTTDYRSLHGK---QSENDDDKGFIIVETNYRLYAYTS 306

  Fly   351 SPLQVAVLGLFTELLYRFPNLVVGVLTRDSVRQALRGGITAEQIVSYLEQYAHPNMRMVESAIHS 415
            ||||:|::|||..|..||.||||||:||||:|:||..||.||||::||..:|||.||      .:
pombe   307 SPLQIAIIGLFANLRARFSNLVVGVITRDSIRRALMNGIAAEQIITYLTTHAHPQMR------SN 365

  Fly   416 KSCLPPTVVDQIKLWELERNRFTYTEGVLYNQFLSHTDFVTLRDYAQSIHMLVWQNERTRTMVVQ 480
            ...||||:||||.|||||:||...|.|:|:..||:.:.|....:||:.:.:|||.:...|...:.
pombe   366 VPLLPPTLVDQIYLWELEKNRLRATPGILFRDFLTDSGFDQAVEYAKELGVLVWDSSLKRMFFIT 430

  Fly   481 KNGHDDVKRYWKK 493
            ..|...:..|.|:
pombe   431 TTGAQPMIAYLKR 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mrn	NP_648780.1	Tfb2	39..403	CDD:281797	145/373 (39%)
tfb2	NP_596563.1	tfb2	8..446	CDD:273180	182/468 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	236	1.000	Domainoid score	I476
eggNOG	1	0.900	-	-		E1_COG5144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7090
Inparanoid	1	1.050	291	1.000	Inparanoid score	I632
OMA	1	1.010	-	-		QHG54356
OrthoFinder	1	1.000	-	-		FOG0004312
OrthoInspector	1	1.000	-	-		oto100828
orthoMCL	1	0.900	-	-		OOG6_101881
Panther	1	1.100	-	-	LDO	PTHR13152
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1501
SonicParanoid	1	1.000	-	-		X3583
TreeFam	1	0.960	-	-
	14	13.860