DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and MASTL

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_001307686.1	Gene:	MASTL / 84930	HGNCID:	19042	Length:	884	Species:	Homo sapiens

Alignment Length:	887	Identity:	201/887 - (22%)
Similarity:	315/887 - (35%)	Gaps:	255/887 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   807 AGAEGITGGSAATATGSG--AQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKN 869
            ||::...||.|||..|..  |....|...:|.|||.||.||:|.|||  .:...:.:|:|.:.|.
Human     5 AGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYL--GQKGGKLYAVKVVKKA 67

  Fly   870 NLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADM 934
            ::|.:|...||.||||.|:.:.:||:|.:|.|.::..::.|||||:.|||..:||...|....:|
Human    68 DMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEM 132

  Fly   935 ARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSE 999
            |..|.:|..||::|||.:||:||||||||:||:..||||||||||||:.|
Human   133 AVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTL--------------- 182

  Fly  1000 TRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEE------LFA 1058
            .|..:...:..||....|    ||.|.:     :.|.:|  .||..:.|.....|:      :.:
Human   183 NRDINMMDILTTPSMAKP----RQDYSR-----TPGQVL--SLISSLGFNTPIAEKNQDPANILS 236

  Fly  1059 HTVNDDIEWPDSEDWPVQAEAKD--------------------------IISQLLQQNPRDRLGT 1097
            ..:::..:.......|:..:.||                          :.|.|||.  |.||.|
Human   237 ACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQS--RKRLAT 299

  Fly  1098 QSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDTDDT-- 1160
            .|.:  .:.|.:...::.......|.|                           :|..::|:.
Human   300 SSAS--SQSHTFISSVESECHSSPKWE---------------------------KDCQESDEALG 335

  Fly  1161 PVFGSFNSY------------TPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSR------- 1206
            |...|:|:.            |..:.|:....:  .:|.....|.||......:|..:
Human   336 PTMMSWNAVEKLCAKSANAIETKGFNKKDLELA--LSPIHNSSALPTTGRSCVNLAKKCFSGEVS 398

  Fly  1207 --AQETPAATVGA-TSTGALPKLKS---GMGSGSGSGSGSGSGSA-------------------- 1245
              |.|.....:.. |.|..|...:|   .:.||..|....|..|.
Human   399 WEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKK 463

  Fly  1246 -----SHDGVVNKFLN-----TPQLRKLDLS----------------SSCLKVPSTPDADYLPEL 1284
                 .|:.:.|.:.|     |.:::.|.||                :|......||:...:|.:
Human   464 TCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMI 528

  Fly  1285 LHNV--TIGNDAELRMLKHYLQ-----QPNPGATQRMQQRHSMPPNTTTIISTPATPPPTQTQAT 1342
            ..|:  .:..|.|....:.||.     ..:..|::.:...........:|:.:|....|..:
Human   529 AKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDS--- 590

  Fly  1343 MAATPPTATVGSFSRSTPESSQTDSDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSSTE 1407
                         .||..|||..:|:...|.|....   |.....|:   .:|:..:   ..|.:
Human   591 -------------DRSIKESSFEESNIEDPLIVTPD---CQEKTSPK---GVENPAV---QESNQ 633

  Fly  1408 NMNLPREQSPLALQHQPKSMDGSTSGSSVKHHRSRSIVKSASALGLSLMTSLDNSQLAAQLCGIQ 1472
            .|..|    ||.:.....|...:.:..|...|.:.|.....|.:.   |||||...::....|..
Human   634 KMLGP----PLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMN---MTSLDAMDISCAYSGSY 691

  Fly  1473 ----SPGGGGNGSSTASSRDTSPCRELSPLV---TNLKPPIIIRRGPRGFGFTVHTIRVYYGDTD 1530
                :|        |...|...|.::....:   |..:.|..:|||
Human   692 PMAITP--------TQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRG------------------- 729

  Fly  1531 FYTMHHLVMAVDE----GSPAFEAGLRPADLITHVNGEAVQG 1568
                   |..||:    |:|.:   |.|..|:...:|....|
Human   730 -------VAPVDDGRILGTPDY---LAPELLLGRAHGFLTSG 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070
		STKc_MAST	834..1115	CDD:270760	100/312 (32%)
		S_TKc	835..1110	CDD:214567	100/306 (33%)
		PDZ_signaling	1506..1587	CDD:238492	13/67 (19%)
MASTL	NP_001307686.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		8/17 (47%)
		STKc_MASTL	30..>223	CDD:270761	87/220 (40%)
		SPS1	34..399	CDD:223589	114/425 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	566..632		14/90 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..728		4/27 (15%)
		PKc_like	<709..875	CDD:304357	15/82 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900