DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and AT3G17850

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_188412.2	Gene:	AT3G17850 / 821054	AraportID:	AT3G17850	Length:	1296	Species:	Arabidopsis thaliana

Alignment Length:	1377	Identity:	344/1377 - (24%)
Similarity:	530/1377 - (38%)	Gaps:	367/1377 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SRQEGAASRPAD------GATGPVAS---SSSSTSSNHSVSAVLG--------SKISTSTPQKND 49
            |::.|::|..:.      |:..|:.|   .|.|.|.:.....:.|        ::|.....:|:.
plant    11 SKKSGSSSPDSSNSPRSVGSNSPIRSDKKKSKSASKDEPPIPIPGFVGVGCKQTQIKDGLKKKDG 75

  Fly    50 EHQEQEFINQSVASEIEAMSISDSASAESSSGATATATATMSG----SPVPKRHLSTANLSRIRP 110
            ..:     .:.::||::|.||..|..:.||............|    ||:   ..|:..|:||:.
plant    76 SSK-----GKQLSSEVQAHSIGKSNLSPSSEVKKPPPPEVKEGPAFVSPI---MASSLGLNRIKT 132

  Fly   111 QSSYSARVLIFDDSDQEAAAAAAALAA------------ASSSCNSSVKSCS---GLE--LLPTS 158
            :|....:..:|:..:..|.:..:.:.|            .|.|.|...::.|   |||  :..|.
plant   133 RSGPLPQERVFNYRNDPATSNLSKMGADGGDLGSGSATSGSGSGNRKKEAGSSKLGLEENMDRTR 197

  Fly   159 PAKLSIGNDSTN-GSSMMRNLNLTKSSSG-------GLSGSSSSLHSRGYTALLRKISYQQHTNS 215
            |:......||.: .:...|:|:.|...||       ..||:..|..|.|.:..||...:....||
plant   198 PSDNKSDRDSLSPDTGPPRSLSPTLPPSGSRLQNVASSSGTGRSEMSSGRSGPLRNSDFCTPENS 262

  Fly   216 LRAVSGETSN------LLRMRHSSLGKSAP--CLTGNY--FRHELTA----PLPVQPPGFGASPL 266
            ....:.:.|.      ||||      .|||  ...|:.  |.|||.:    |.|:..|....:..
plant   263 YEWENPKESESPRYQALLRM------TSAPRKRFPGDIKSFSHELNSKGVRPFPLWKPRRSNNVE 321

  Fly   267 GGHNISRSGSCAGIGLAKHHHHHHLHGVVMRGSAGGGAGSGGGSSSGVAHHRLSLVTNSAAVAAA 331
            ...|:.|    |....||..                                   |.:..||.||
plant   322 EVLNLIR----AKFEKAKEE-----------------------------------VNSDLAVFAA 347

  Fly   332 G-------GSRTHSPYSASPVD------SPRLNSPMPFAFAPIKRIASCRGVV--ADGRR----- 376
            .       .:.:|..:..:..|      |..:.:|..|..       .|.|:|  .|.||
plant   348 DLVGVLEKNAESHPEWEETFEDLLILARSCAMTTPGDFWL-------QCEGIVQDLDDRRQELPP 405

  Fly   377 ---------------------------W----------------SVASLPSSGYGTT------PG 392
                                       |                |:..:|.||.|.:      |.
plant   406 GVLKQLHTRMLFILTRCTRLLQFHKESWGEEEQVVQLRQSRVLHSIEKIPPSGAGRSYSAAKVPS 470

  Fly   393 SSNLSSQCSSQEGL----NQLAHNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQ 453
            :....||  .|.||    :.:..::||...                     |::.|:       :
plant   471 TKKAYSQ--EQHGLDWKEDAVVRSVPPLAP---------------------PENYAI-------K 505

  Fly   454 LTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSPY 518
            .:..|....::...|.:.:..:....|              |......|.|......:.|
plant   506 ESESPANIDRMSSWKKLPSPALKTVKE--------------APASEEQNDSKVEPPNIVG----- 551

  Fly   519 FRPRSRSLSSPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLK-------------LFINENKS 570
                       ||....|..:|::|      ||.|....|...|             ..|:|..|
plant   552 -----------SRQGRDDAAVAILN------FPPAKDSHEHSSKHRHNISWGYWGEQPLISEESS 599

  Fly   571 AACNSFRDSQPIVRFVHHQVLEMARDC--LHKSEAK-LITSQYFYELSENLERLLVETKEKSPEA 632
            ..|....:..|......|     :|.|  ..|.:.| |...:....::..|:::....:.|...|
plant   600 IMCRICEEEVPTTHVEDH-----SRVCTLADKYDQKGLSVDERLMAVAGTLDKIAETFRHKDSLA 659

  Fly   633 AAEL--------------NGVIKKLLLIISRPAR--LLECL-EFDPQEFYELLEA---------- 670
            |||.              :.|:...|...||...  :|:|. |.|...|.:.|..
plant   660 AAESPDGMKVSNSHLTEESDVLSPRLSDWSRKGSEDMLDCFPEADNSIFMDDLRGLPLMSCRTRF 724

  Fly   671 --------AEGHAKAM------PVIKADIPQYIIHKLGL--NRDPIAELQQELRETQQMCSEQVT 719
                    ....|.:|      |..:.|..:.|:...|.  ::|.|.:: .||.:..:..::.:.
plant   725 GPKSDQGMTTSSASSMTPRSPIPTPRPDPIEQILGGKGTFHDQDDIPQM-SELADIAKCAADAIP 788

  Fly   720 VDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATCDTAPSFALAI 784
            .| |...|    .|.|.|......:.....||:.::: .||...:...:..|..|:.
plant   789 GD-DQSIP----FLLSCLEDLRVVIDRRKFDALTVET-FGTRIEKLIREKYVHMCEL-------- 839

  Fly   785 SQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPSPQENDFDIVKLISNGAYGAV 849
              |::||....|.|    ..:.|..|.....|..|:......:.|  .:||:|:|.||.||:|.|
plant   840 --MDDEKVDLLSTV----IDEDAPLEDDVVRSLRTSPVHPRDRTS--IDDFEIIKPISRGAFGRV 896

  Fly   850 YLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEY 914
            :|.|.:||...||:|.:.|.::|.:|.||.:.||||||....|||||..:.||..:.:|.|||||
plant   897 FLAKKRTTGDLFAIKVLKKADMIRKNAVESILAERDILINVRNPFVVRFFYSFTCRDNLYLVMEY 961

  Fly   915 VEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGL 979
            :.|||..:||:|:|.|..|:.|.|.||.|||:|||||.|:||||||||||||...||||||||||
plant   962 LNGGDLYSLLRNLGCLEEDIVRVYIAEVVLALEYLHSEGVVHRDLKPDNLLIAHDGHIKLTDFGL 1026

  Fly   980 SKMGLMSLATNLY------EGYIDSETRQF--SDKQV--------YGTPEYIAPEVILRQGYGKP 1028
            ||:||::...:|.      ...:|.|..:.  |::|:        .|||:|:|||::|..|:|..
plant  1027 SKVGLINSTDDLAGPAVSGTSLLDEEESRLAASEEQLERRKKRSAVGTPDYLAPEILLGTGHGAT 1091

  Fly  1029 VDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRD 1093
            .||||:||||:|.::|..||..|..:::|.:.:|..|.||...: .:.|||.|||.:.|.::|..
plant  1092 ADWWSVGIILFELIVGIPPFNAEHPQQIFDNILNRKIPWPHVPE-EMSAEAHDIIDRFLTEDPHQ 1155

  Fly  1094 RLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDTD 1158
            |||.: ||.|:|:|.:|..::|::|.||||.|||......|||||   ..||:.:...|....:.
plant  1156 RLGAR-GAAEVKQHIFFKDINWDTLARQKAAFVPASESAIDTSYF---RSRYSWNTSDEQFFPSG 1216

  Fly  1159 DTPVFGSFNSYT 1170
            :.|.:...:|.|
plant  1217 EVPDYSDADSMT 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	78/482 (16%)
		STKc_MAST	834..1115	CDD:270760	139/296 (47%)
		S_TKc	835..1110	CDD:214567	137/290 (47%)
		PDZ_signaling	1506..1587	CDD:238492
AT3G17850	NP_188412.2	S_TKc	882..1171	CDD:214567	137/290 (47%)
AT3G17850	NP_188412.2	STKc_MAST_like	888..1176	CDD:270731	135/289 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	265	1.000	Domainoid score	I458
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2780
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810