Protein Alignment dop and mast1a

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: XP_009292706.1
• Gene: mast1a / 796739
• ZFINID: ZDB-GENE-121214-221
• Length: 1738
• Species: Danio rerio
• Alignment Length: 1909
• Identity: 706/1909 - (36%)
• Similarity: 914/1909 - (47%)
• Gaps: 545/1909 - (28%)

  Fly   311 SSGV-AHHRLSLVTNSAAVAAAGGSRTHSP----YSASPVDSPRL---NSPMPFAFAPIKRIASC 367
            |||. ..:|.||:..|.:...   .|.|||    ..:||:||||.   ::|..|:||..:|
Zfish    26 SSGCRTSNRKSLILTSTSPTL---PRPHSPLPGHIGSSPLDSPRTFSPSAPAHFSFASSRR---- 83

  Fly   368 RGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCA 432
                |||||||:||||||||||...||..||  ||||.|:||
Zfish    84 ----ADGRRWSLASLPSSGYGTNTPSSTSSS--SSQERLHQL----------------------- 119

  Fly   433 EHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANG 497
                                     |.:|| |.....:|                       .:.
Zfish   120 -------------------------PFQPT-LDELHFLT-----------------------KHF 135

  Fly   498 GSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLK 562
            ||:     .|.....||.||:.||||||||....|...||||.:||.:|||||||||.||||||.
Zfish   136 GST-----ESITDDDGRRSPHMRPRSRSLSPGRSSSCYDNEIVMMNHVYKERFPKATAQMEERLA 195

  Fly   563 LFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKE 627
            .||............|.  ::.|:|||:.|::|:||.||...|||:.|||||.||||:||.|..|
Zfish   196 DFIESYSPENVLPLADG--VLSFIHHQIAELSRNCLTKSREGLITTVYFYELQENLEKLLHEAYE 258

  Fly   628 KSPEAAAELNGV---IKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYI 689
            :|  .::||..:   :|||.:||||||||||||||:|:|||.||||||.|||...::|||||:||
Zfish   259 RS--ESSELTFITELVKKLFIIISRPARLLECLEFNPEEFYHLLEAAEDHAKEGQLMKADIPRYI 321

  Fly   690 IHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAM 754
            |.:|||.|||:.::                                             ::..:.
Zfish   322 ISQLGLTRDPLEDM---------------------------------------------VNLESY 341

  Fly   755 DSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAAT 819
            ||        :.|.|| .|.|:|.....||.
Zfish   342 DS--------EGPHTP-ETDDSAEGKLKAIK---------------------------------- 363

  Fly   820 ATGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAER 884
                     .|.|:||..:||||||||||||||:|:.||||||||||||.|||||||::|.|.||
Zfish   364 ---------PPCESDFQTIKLISNGAYGAVYLVRHRETRQRFAMKKINKQNLILRNQIQQAFVER 419

  Fly   885 DILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYL 949
            |||:||:|||||||:|||||::|||:||||||||||.|||||||.||.||||.||||||||:||:
Zfish   420 DILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVDMARMYFAETVLALEYI 484

  Fly   950 HSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEY 1014
            |:||||||||||||||||::||||||||||||||||:|.||||||:|:.:.|:|.||||.|||||
Zfish   485 HNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMNLTTNLYEGHIEKDAREFLDKQVCGTPEY 549

  Fly  1015 IAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEA 1079
            ||||||||||||||||||:|||||||||:|||||||:|.||||...:.|.||||:.:: .:.|:|
Zfish   550 IAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVITDYIEWPNGDE-ALPADA 613

  Fly  1080 KDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDR 1144
            :.:||.|||.||..|||| .||.|:|:|.:|.|:|||.||||||||:|.|..::||||||||.:|
Zfish   614 QSLISSLLQTNPLVRLGT-GGAFEVKQHSFFSGLDWNGLLRQKAEFIPHLESEEDTSYFDTRSER 677

  Fly  1145 YNHDLGGEDTDDT-DDTPV-FGSFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRA 1207
            |.| :...|.||| ||.|| ...|:|.:|::.|. ||...|                ||.|   .
Zfish   678 YRH-INSYDEDDTNDDEPVEIRQFSSCSPRFSKV-YSSMEH----------------LSQL---E 721

  Fly  1208 QETPAATVGATSTGALPKL--KSGMGSGSGSGSGSGSGSASHDGVVNKFLNTPQLRKLDLSSSCL 1270
            |:||..|..........|:  :...||.|.......:||             |::::|..|.|.
Zfish   722 QKTPVVTRREHKGRRDDKITKRESFGSFSMRDKSWRTGS-------------PEMKRLSCSESL- 772

  Fly  1271 KVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQ---QPNPGATQRMQQRHSMPPNTTTIISTPA 1332
                                           |::   .|..||    ::|.|...:|....|:..
Zfish   773 -------------------------------YMEGDCSPPMGA----RRRFSALMDTHRFASSQE 802

  Fly  1333 TPPPTQ-----TQATMAATPPTATVGSFSRSTPE----SSQTDSDDFS-------PQI--NRKRK 1379
            .....|     |.::..|.||::...:..|:..|    ||...:|..|       ||.  :....
Zfish   803 GDGERQVTAKATGSSEGAVPPSSPSANEQRNGKEVMSISSSKSTDKASRPGEVSAPQTIPSTGAP 867

  Fly  1380 GVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQPKSMDGSTSGSSVKHHRSRSI 1444
            .|.:||:     ::|.|   ..|..:|:::.|.|      .:||..|.||....|    .....:
Zfish   868 AVISRDL-----VAIGD---PVGQRATKDLVLRR------ARHQQLSSDGEKRTS----RPGNKV 914

  Fly  1445 VKSASALGLSL----MTSLDNSQLAAQLCGIQSPGGGGNGSSTASSRDTSPCRELSPLVTNLKPP 1505
            :|||||..||:    :....||.||       ||....:.||..||||:||.|:..|.||..:.|
Zfish   915 IKSASATALSVIIPGVEQHGNSPLA-------SPMSPRSLSSNPSSRDSSPSRDYCPTVTVPRSP 972

  Fly  1506 IIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLF 1570
            |.|:|..:.:|||:..||||.||||.|::||:|..|::|.||.||||...|||||||||:|.||.
Zfish   973 ITIQRSGKKYGFTLRAIRVYIGDTDVYSVHHIVWHVEDGGPAQEAGLCAGDLITHVNGESVHGLV 1037

  Fly  1571 HTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSL 1635
            ||:|::|:|..|..||:..||.|:|||:.|..:|...:||:|:    |.|:..|...:.||:.||
Zfish  1038 HTEVVELILKSGNKVTVTTTPFENTSIKVGPARRSSYKSKMAR----RSKRTVKEGQESKRRGSL 1098

  Fly  1636 FRRI--------SSKRANAEMQQYSAGTSSPTTP--SARNLSPLDSSYHSSCCQSAANSSSQSTS 1690
            ||:|        :|:..::..:..|:..|.|.:|  |....|| ..||.|:...|...:||||:|
Zfish  1099 FRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHSLSGHSP-TQSYRSTPESSHLGASSQSSS 1162

  Fly  1691 PSSSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVP 1755
            |:||:||:|.                              .||
Zfish  1163 PASSTPNSPA------------------------------TTQ---------------------- 1175

  Fly  1756 VSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHI 1820
                      :.|||:||||..|||                          ......|.||.|:|
Zfish  1176 ----------HMRPSSLHGLSPKLH--------------------------RQYRSARCKSAGNI 1204

  Fly  1821 PLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSY------SPGSTLPTLQTAVNAN 1879
            ||||||.||       |||:|..|   ||.||..|:|||||::      ||....|
Zfish  1205 PLSPLAHTP-------SPTQSSPP---PLPGHTVGSSNTTQTFPAKLHSSPPIIRP--------- 1250

  Fly  1880 TKKAGFARTKSAE-PSSPLLRRALSPDRLHPRSAETKISPLCCSPPIK-----QPTHQRVVTTTW 1938
                   |.|||| |.||||:|.        :|||...|||..|...|     ...|...|
Zfish  1251 -------RPKSAEPPRSPLLKRV--------QSAEKLGSPLSSSSEKKGGIGVMRKHSLEV---- 1296

  Fly  1939 RSTPGGSASGAGG--AVLGAPSVQPLQLVPAASEESQRQTAMATVVSTTAAGTDPSATAVVTLAN 2001
                |.|.....|  ..||..|     ||....|.      :|:..:.:.:.|.|:
Zfish  1297 ----GHSDYRKDGFHCELGLQS-----LVEIEGEN------LASAPTNSPSPTQPT--------- 1337

  Fly  2002 CEPLP---------RIAEEKDSPTSTQDSSSVSEGFMPAIEEFAEGESSSSPTQTLEKPTKVKAT 2057
              |||         |....::||.|       .:..:...|...|.|.....|....:|::...:
Zfish  1338 --PLPPETGVLKPVRKLGRQESPLS-------RDALLAGRERERERERERERTGKANEPSRPTES 1393

  Fly  2058 EQPEMEPAGK----SKKVDQGKTTT-------------PGTPKTKPHNSGCKTSMTTTKPASPSV 2105
            :...:.|.|.    :.:..|..|:|             |...|:.|..|..|:::.|:.| ||..
Zfish  1394 KPAAVTPPGSKTSPNSETSQRHTSTIQECCLVKPQTWQPPLTKSSPIASESKSNIVTSIP-SPLT 1457

  Fly  2106 TISTAPRK--DTSAVTGGGSSGSG 2127
            |:|:...|  |.|::...|:...|
Zfish  1458 TVSSPSTKTIDQSSIREEGNDDKG 1481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	156/363 (43%)
		STKc_MAST	834..1115	CDD:270760	209/280 (75%)
		PDZ_MAST	1502..1594	CDD:467189	49/91 (54%)
mast1a	XP_009292706.1	DUF1908	61..334	CDD:462637	156/363 (43%)
		STKc_MAST	369..648	CDD:270760	209/280 (75%)
		PDZ_MAST1	970..1063	CDD:467286	50/92 (54%)