Protein Alignment dop and mast2

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: XP_031756036.1
• Gene: mast2 / 779595
• XenbaseID: XB-GENE-997933
• Length: 2028
• Species: Xenopus tropicalis
• Alignment Length: 2304
• Identity: 781/2304 - (33%)
• Similarity: 1041/2304 - (45%)
• Gaps: 703/2304 - (30%)

  Fly    75 SAESSSGATATATATMSGSPVPKRHLSTANLSRIRPQSSYSARVLIFDDSDQEAAAAAAALAAAS 139
            :||.....:.|..|  ..:||.:|.  ||.     |:...::|       ||:.....|.|....
 Frog     7 NAEKPQPTSGTEEA--RAAPVLRRR--TAG-----PEERAASR-------DQDTVPPPAPLLFRK 55

  Fly   140 SSCNSSVKSCSGLELLPTSPAKLSIGNDSTNGSSMMRNLNLTKSSSG-GLSGSSSSLHSRGYTAL 203
            .| |..:.|.:|         |..:....:.....:|..:|..|.:| .|...|:|:|| |...|
 Frog    56 LS-NPDLYSSTG---------KAKLHRQLSQDDCKLRRGSLASSLAGKQLLPLSNSVHS-GVGQL 109

  Fly   204 LRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLTGNYFRHELTAPLPVQPPGFGASPLGG 268
               .::|.        |.|||||:|||:.|||:|||.||...  .||:.|
 Frog   110 ---TTWQP--------SAETSNLVRMRNQSLGQSAPSLTAGL--KELSLP--------------- 146

  Fly   269 HNISRSGSCAGIGLAKHHHHHHLHGVVMRGSAG------------------------------GG 303
                |.||.....|..|...:.:|...:..|:.                              ..
 Frog   147 ----RRGSLIFSPLHAHCRGNDVHQCALSPSSAPNLQHLKIPFSADCTLDTSPLAFFCSPQPQSN 207

  Fly   304 AGSGGGSS----SGVAHHRLSLVTNSAAVAAAGGSRTHSPYSA----SPVDSPRLNSP---MPFA 357
            .||...|:    |..:.:|.||:..|:.....  .|.|||...    ||:||||..||   ..|:
 Frog   208 PGSPCYSTPLQWSCRSSNRKSLIVASSTSPTL--PRPHSPLHGHTGNSPLDSPRNFSPNAAAHFS 270

  Fly   358 FAPIKRIASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADA 422
            |.|.:|        .||||||:||||||||||...||.:||.|||||.|:||     |....||.
 Frog   271 FVPARR--------TDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQL-----PFQPTADE 322

  Fly   423 AAVAAGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGG 487
                     ...|.:|          .|.:.:|.:.
 Frog   323 ---------LHFLTKH----------FSTESITDEE----------------------------- 339

  Fly   488 QQAGGGAANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSPI-VDNEIAVMNTLYKERFP 551
                                     ||.||..||||||| ||.|.|| .|.||.:||.:||||||
 Frog   340 -------------------------GRHSPAMRPRSRSL-SPGRCPISYDGEIVMMNHVYKERFP 378

  Fly   552 KATQQMEERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSE 616
            |||.||||||..||..|.........|.  ::.|:||||:|:|||||.||...||||:|||||.|
 Frog   379 KATAQMEERLADFIISNSPENVLPLADG--VLSFIHHQVIELARDCLSKSRDGLITSRYFYELQE 441

  Fly   617 NLERLLVETKEKSPEA-AAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPV 680
            |||:||....|:|..: .|.:..::|||::||:|||||||||||:|:|||.||||||||||....
 Frog   442 NLEKLLQNAHERSESSEVAFVTQLVKKLMIIIARPARLLECLEFNPEEFYHLLEAAEGHAKEGEG 506

  Fly   681 IKADIPQYIIHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLS 745
            ||:|||:|||.:|||.|||:.|:.|                           |||
 Frog   507 IKSDIPRYIISQLGLTRDPLEEMAQ---------------------------LNS---------- 534

  Fly   746 SLALDAIAMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAE 810
                    .|| |...||:                             :...|.|.|
 Frog   535 --------YDS-SNADTPE-----------------------------TDDCVEGRS-------- 553

  Fly   811 GITGGSAATATGSGAQQP--SPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLIL 873
                       |:...||  :|.|..|:.:|||||||||||:||:||.||||||||||||.||||
 Frog   554 -----------GAALIQPKKTPSEEQFENIKLISNGAYGAVHLVRHKETRQRFAMKKINKQNLIL 607

  Fly   874 RNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFY 938
            |||::|.|.|||||:||:|||||||:||||||:|||:||||||||||.||||:||.||.||||.|
 Frog   608 RNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKSIGALPVDMARMY 672

  Fly   939 FAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQF 1003
            |||||||:||||:||||||||||||||||::||||||||||||:|||||.||||||:|:.:||:|
 Frog   673 FAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDTREF 737

  Fly  1004 SDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWP 1068
            .||||.|||||||||||||||||||||||:||:||||||:|||||||:|.||||...::|:|.||
 Frog   738 LDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGVILYEFLVGCVPFFGDTPEELFGQVISDEIAWP 802

  Fly  1069 DSEDWPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDD 1133
            |.:| .:.|:|:|:||:||:|||.:||||.| |:|:|:|.:|..:|||.||||||||:|||..:|
 Frog   803 DGDD-ALPADAQDLISRLLRQNPLERLGTGS-AIEVKQHRFFKDLDWNGLLRQKAEFIPQLESED 865

  Fly  1134 DTSYFDTRMDRYNHDLGGEDTDDT--DDTPVFGSFNSYTPQYRKQHYSWSRHATPTSTDGAKPTG 1196
            ||||||||.:||.| :..|:.:||  :|......|:|.:|::.|.:.|..|
 Frog   866 DTSYFDTRSERYQH-MDSEEEEDTNDEDRVEIRQFSSCSPRFSKVYSSMER-------------- 915

  Fly  1197 PPPLSSLPSRAQETPAATVGATSTGALPKLKSGMGSGSGSGSGSGSGSASHDGVVNK----FLNT 1257
                  |....:.||..|..:.|.....|| .|:|                 |:.|:    .:.:
 Frog   916 ------LSIHEERTPPPTKRSLSEEKEDKL-DGLG-----------------GLKNRDRGWVIGS 956

  Fly  1258 PQLRKLDLSSSCLKVPSTPDADYLPEL-----------LHNVTIGNDAELRMLKHYLQ-QPNPGA 1310
            |::.:..||:|   ..|..::|..|.|           :....|..:.||.:.:...| |.:..|
 Frog   957 PEILRKRLSAS---ESSHTESDSSPPLTVRRRCSALVDMPRFAISTEEELHLQRKLSQSQQDALA 1018

  Fly  1311 TQRMQQRHSMPPNTTTIISTPATPPPTQTQA----TMAATPPTATVGSFSRSTPESSQTDSDDFS 1371
            :....|:...|        .|....|.:.:.    .:..:.|::|:.:.|.||
 Frog  1019 SPSSLQKDGNP--------LPILEQPVERELKLDDELVPSTPSSTISNISSST------------ 1063

  Fly  1372 PQINRKRKGVCARDILPRFSISIEDETISAGSS---STENMNL-------PREQSPLALQHQPKS 1426
                                      |::|||:   |..|:.:       |:..|.||::.....
 Frog  1064 --------------------------TLTAGSNADFSDNNIGIDVSEFASPKAISDLAVRRARHR 1102

  Fly  1427 MDGSTSGSSVKHHRSRSIVKSASALGLSLMTSLD---NSQLAAQLCGIQSPGGGGNGSSTASSRD 1488
            :....||..........::|||||..||||...|   .|.||       ||....:.||..||||
 Frog  1103 LLSGDSGEKRPSRPVNKVIKSASATALSLMIPSDYHTYSPLA-------SPMSPHSLSSNPSSRD 1160

  Fly  1489 TSPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLR 1553
            :||.|:..|.:::|||||||.|..:.:|||:..||||.|::|.||:||:|..|:|..||.:||||
 Frog  1161 SSPSRDFFPAISHLKPPIIIHRAGKKYGFTLRAIRVYMGESDVYTVHHMVWHVEEDGPAHDAGLR 1225

  Fly  1554 PADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNR 1618
            ..|||||||||.|.||.||:|::|:|..|..|::..||.|:|||:.|..::...:||:|::   .
 Frog  1226 EGDLITHVNGEPVHGLVHTEVVELILKSGNKVSISTTPFENTSIKVGPARKASYKSKMARR---N 1287

  Fly  1619 QKKQTKREHDKKRKTSLFRRI--------SSKRANAEMQQYSAGTSSPTTPSARNLSPLD--SSY 1673
            :|.:.|...:.|:|.||||:|        :|:..::..:..|:|.|.|.:|: ..|||..  .:|
 Frog  1288 KKSKPKDGQESKKKCSLFRKITKQASLLHTSRSLSSLNRSLSSGESVPGSPT-HVLSPRSPTQTY 1351

  Fly  1674 HSS--CCQSAANSSSQSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVL 1736
            .|:  ...|...:||||:|||||.||:| .|||
 Frog  1352 RSTPDSTHSVGGNSSQSSSPSSSVPNSP-ASSG-------------------------------- 1383

  Fly  1737 LPHVGAVVGSNPTSVGNVPVSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKT 1801
              |:                           |||:||||..||..         ...:|
 Frog  1384 --HI---------------------------RPSSLHGLAPKLQR---------QYRSP------ 1404

  Fly  1802 LHTTNNNSLPNRRKSVGHIPLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSY--- 1863
                       ||||.|:|||||||.||||:...:||.||||||.    ||..|..|..||:
 Frog  1405 -----------RRKSAGNIPLSPLAHTPSPTSQSTSPQRSPSPLP----GHTLGNCNILQSFPVK 1454

  Fly  1864 ---SPGSTLPTLQTAVNANTKKAGFARTKSAE-PSSPLLRRALSPDRLH-PRSAETKIS------ 1917
               ||    |.::.          .:|.|||| |.||||:|..|.::|. ..|:|.|::
 Frog  1455 LHSSP----PLVRQ----------ISRPKSAEPPRSPLLKRVQSAEKLSGSLSSEKKLASSRKHS 1505

  Fly  1918 -----------------PLCCSP-----------------PIKQPT-------HQRV-------- 1933
                             .|.|.|                 .:::|:       |.||
 Frog  1506 LDISHSDFKKEIMHRDLSLQCLPESMSENTGGKVGLAEKGTLQKPSRKLGAIRHDRVERRESLQK 1570

  Fly  1934 ------VTTTWRSTPGGSASGAGGAVL-----------------GAPSVQPLQ---------LVP 1966
                  |.::...|..||.....|..|                 |..|.|...         |:|
 Frog  1571 QEAIREVDSSEDETDEGSEDSQDGRRLERASFRNEKVSASAISSGRDSCQKQSKSSTEDDSFLLP 1635

  Fly  1967 AASEESQ-RQTAMATVVSTTAAGTD-------------PSATAVVTLANCEPLPR---IAEEKDS 2014
            ....:|: ::||...|:..|...|.             |..|.::..|....|.:   :..|.::
 Frog  1636 DYRRKSEVKETAGRKVIDVTLQNTPDQSGIRSFCSPNLPPDTCLIPAAEINMLKQQNILKREVNA 1700

  Fly  2015 ----PTSTQDSSSVSEGFMPAIEEFAEGESSSSPTQTLEKPTKVKATEQPEMEPAGKSKKVD-QG 2074
                ....|:|:..|.|            :....||.:....:..::..|.:..:.||..|. :.
 Frog  1701 MQIQGKPLQESNQQSTG------------TDRKNTQNIVVQKEADSSSDPHLCQSSKSSCVSIEA 1753

  Fly  2075 KTTTPGTPKTKPHN----SGCKTSMTTTKPASPSVTISTAPRKDTSAVTGGGS------------ 2123
            ....|...:|.|.:    |....|.:..|..|.||.:..: ..||.:.|...|
 Frog  1754 HLEVPNCKETLPEDGSKESALSLSSSCLKTTSNSVAVHCS-AGDTCSTTSTASDAYVQYLPVVNE 1817

  Fly  2124 -------------SGSGGSAATSAAKQRK 2139
                         .|...|.:|.|...||
 Frog  1818 QGQQEPAEKQSTLKGMNNSVSTEATLSRK 1846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	161/362 (44%)
		STKc_MAST	834..1115	CDD:270760	210/280 (75%)
		PDZ_MAST	1502..1594	CDD:467189	51/91 (56%)
mast2	XP_031756036.1	DUF1908	254..528	CDD:462637	161/362 (44%)
		STKc_MAST	568..847	CDD:270760	210/280 (75%)
		PDZ_MAST2	1174..1266	CDD:467287	51/91 (56%)